140results about How to "Effective targeting" patented technology

The present systems and methods relate to marketing health products and health services. One or more marketing presentations are made to a health consumer about one or more health products or health services. The marketing presentations are targeted based on health data regarding the health consumer and optionally data regarding the health provider. The present systems and methods allow life science companies, government entities and others to more efficiently and effectively market health products and/or health services to health consumers and health providers.

The present invention is a method and system for automatically changing the advertisement contents on a means for displaying the contents based on a customer's behavior or a group of customers' behavior in a retail store. The analysis of behavioral pattern is performed automatically and in real-time based on the visual information from the shopping and walkthrough history of a customer or a group of customers, using arrays of sensing devices, such as a plurality of means for capturing images, and a plurality of computer vision technologies on the visual information.

Improved risk categorization is provided for clinical decision support and forecasting future health care spend. A risk index is provided that improves on other risk stratification models by synthesizing electronic medical records and health questionnaires with an individual patient's claim histories. Machine learning algorithms catalogue patients into distinct group clusters, based on risk which may be associated with annual health care spending, thereby enabling administrators to forecast future health care spending on the individual and population level.

Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.

Bioadhesives coatings increase the gastrointestinal retention time of orally-ingested medicaments. Certain bioadhesive coatings producing a fracture strength of at least 100 N/m², as measured on rat intestine, when applied to at least one surface of a pharmaceutical dosage form for oral delivery of a drug, result in a gastrointestinal retention time of at least 4 hours in a fed beagle dog model, during which the drug is released from the dosage form.

Multi-layer tablets, particularly those including hydrophobic excipients, are useful in administering hygroscopic and/or deliquescent drugs. In addition, varying the amount of drug in multi-layer tablets allows the release rate of the drug to be controlled.

The present invention is directed to the systems, computer program products, methods and devices that encourage users of applications for mobile devices to watch and/or to share videos. In some embodiments, users are provided with the opportunity to purchase goods or services in exchange for having viewed a video within the context of an application. These users may also be provided with the opportunity to purchase goods or services in exchange for sharing the videos through social media. Alternatively od additionally, they may be presented with opportunities for reengaging applications that they previously used but for which they have decreased the frequency with which they use those applications or have ceased using those applications.

The invention discloses long-circulating solid lipid docetaxel nanoparticles and a preparation method thereof. The long-circulating solid lipid docetaxel nanoparticles comprise the following materialsin therapeutic effective dose: docetaxel, lipid materials, long-circulating auxiliary materials and an emulsifier. The long-circulating solid lipid docetaxel nanoparticles have small particle size, high encapsulation rate and good stability, and not only improve the solubility and the stability of the docetaxel, reduce the toxicity of the docetaxel, but also prolong the circulating time of a medicament in blood, and improve the therapeutic index of the medicament, so that the preparation has the characteristics of low toxicity, low allergy, high efficiency and targeting in clinical application.

Methods are provided for producing functional antigen presenting dendritic cells. The dendritic cells are produced by treating an extracorporeal quantity of a subject's blood to induce differentiation of blood monocytes into dendritic cells. The dendritic cells may be exposed to cellular material encapsulated within a biodegradable polymer material to produce the antigen presenting dendritic cells.

Provided are novel antibody drug conjugates (ADCs), and methods of using such ADCs to treat proliferative disorders.

A flexible, closed loop device that includes at least one indecomposable knot formed that helps define a plurality of adjustable loops. The knot can be easily loosened so that the loop sizes can be adjusted. The knot is easily tightened and locked. In some embodiments, the device includes at least two indecomposable knots. The device is useful in the practice of yoga, Pilates, and other personal training exercises. The device is flexible and easily adjustable, allowing the user to more effectively target specific muscle groups. The device may additionally or alternately be used as a securing and carrying strap for items. Still further, the device may be used as a connecting device to link items together for towing, hoisting, etc.

A method for assessing risk of a harmful outcome includes obtaining at least one writing containing a threat directed to a target by an author of the writing. The method includes the further steps of identifying at least one outcome-predictive language use strategy, at least one outcome-predictive document feature, and at least one outcome-predictive psychological characteristic of the author. These variables are used to generate a numerical value predictive of a harmful outcome, that is, the author carrying out the threat. The present method may be used to predict risk of a harmful outcome from a single writing. In one aspect, the present method provides a formula predictive of risk of a harmful outcome based on analysis of at least one writing.

The present invention relates to chemical modification motifs for oligonucleotides. The oligonucleotides of the present invention, such as chemically modified antisense oligonucleotides, can have increased in vivo efficacy. The chemically modified oligonucleotides provide advantages in one or more of potency, efficiency of delivery, target specificity, toxicity, and/or stability. The chemically modified oligonucleotides have a specific chemical modification motif or pattern of locked nucleic acids (LNAs). The oligonucleotide (e.g. antisense oligonucleotide) can target RNA, such as miRNA or niflNA. Also provided herein are compositions comprising the chemically modified oligonucleotides and methods of using the chemically modified oligonucleotides as therapeutics for various disorders, including cardiovascular disorders.

Embodiments of the invention provide a robust rebate cross-sell network in which business entities, including financial institutions, can make targeted offers, including pre-approved or pre-qualified credit offers, to a desirable consumer utilizing information submitted by the consumer during a rebate redemption process. These business entities may but need not be associated with a rebate-issuing entity (i.e., rebate sponsor) or a rebate processing center which processes rebate claims for the rebate sponsor. In one embodiment, a cross-sell network manager can determine the consumer's identity, look-up the consumer at credit bureau(s), and perform a passive, real-time inquiry. Contingent upon a plurality of factors (e.g., the results of the inquiry or look-up against the pre-approved/qualified customer list, etc.), one or more targeted offers are identified. A Web page can be dynamically generated with the selectively identified offers and presented to the consumer as disbursement options, perhaps after authenticating the consumer's identity.

Indication of uncoverage information allows tests to be tailored to target those uncovered code units with the most potential to increase coverage of a program. A tool examines coverage information of a program to identify code units of the program that were not covered by test data used to exercise the program. The tool also examines structural information (e.g., control flow) for the program to identify those of the uncovered code units that have direct control flow from a corresponding covered code unit (“root level uncovered code units”). The coverage tool then measures potential impact on coverage for each of the root level uncovered code units.

The invention provides an MOFs type nanometer drug and a preparation method thereof in order to improve the deficiencies in an existing nanometer drug preparation technology. ZIF-8 is adopted as a drug delivery carrier, glucose oxidase (GOx) is encapsulated into channels of the ZIF-8, and MnO2 nanometer particles are supported to prepare the GM-ZIF-8 nanometer composite drug. The method for preparing the GM-ZIF-8 nanometer composite drug is simple in operation and mild in reaction condition, and no complicated preparation instruments are needed. The nanometer drug has a good inhibition effecton tumor cell proliferation.

The invention discloses aptamer-modified targeted drug delivery nanoparticles as well as a preparation method and application thereof. The targeted drug delivery nanoparticles are nucleic acid aptamerin which by taking mesoporous silica nanoparticles as a vector, an anticancer drug and a photosensitizer are entrapped in channels of the mesoporous silica nanoparticles, and specific proteins whichcan recognize cancer cell surfaces are modified on the surfaces of the mesoporous silica nanoparticles. The targeted drug delivery nanoparticles can recognize tumor cells in a targeted manner, exertscombined curative effect of chemotherapy/photodynamic therapy and can be used for preparing an antitumor drug.

The invention relates to an intelligent teaching system for ideological and political education. The intelligent teaching system for ideological and political education includes a login terminal, a student terminal, a teacher terminal, a management terminal and a retrieval terminal, wherein the teacher terminal and the student terminal interact with the management terminal through the login terminal; the login terminal includes a verification module and an authorization module; the management terminal includes an administrator interface, an administrator module, a teacher management module, a class management module, a student management module, a common resource management module, a course management module and an announcement management module; the teacher terminal includes a teacher interface, a course display module, a teach resource browse module, a teacher communication module, a teacher knowledge management module, a teacher material information storage module and a teacher retrieval interface; and the student terminal includes a student interface, a learning module, a student resource browse module, a student communication module, and a student knowledge management module.

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.