A pathogen-proof and humane rodent trap that asphyxiates the rodent inside of a small airtight compartment so that the dead animal cannot act as a source for production or distribution of infectious organisms, and can be safely disposed of. Two embodiments are shown, one comprising two telescoping tubular members compressed together by a rubber band or the like, and a break-away bait stick is lodged between the two tubular members to hold them apart. When a rodent chews the bait stick it breaks away, compressing the tubular members together and sealing off the entrance aperture. In another embodiment, a single cantilevered tubular member is used, and it rests on a central fulcrum to allow tipping one way or another. A trap door is folded under one end of the tubular member and it snaps shut when the tubular member is tipped. Both designs are humane and sanitary, simple to use, effective, child and pet safe, small, disposable, and inexpensive to manufacture.