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Medicinal composition for treating pullorum disease and preparation method thereof

A composition and pullorum technology are applied in the directions of pharmaceutical formulations, drug delivery, medical preparations containing active ingredients, etc., can solve problems such as affecting physical health, difficulty in clinical medication, drug residues, etc., and achieve good safety and low cost. , the effect of low price

Inactive Publication Date: 2010-12-29
HENAN XINZHENGHAO BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the overall drug resistance rate of Salmonella bacteria to antibiotics is between 1.4% and 90%. Antibiotics have developed high drug resistance, and also showed drug resistance to fluoroquinolones such as ciprofloxacin, norfloxacin and cephalosporins such as ceftriaxone, which brought great difficulties to clinical drug use
At present, in veterinary clinics, when treating Salmonella, the clinical dosage of quinolones such as ciprofloxacin lactate has reached the recommended dosage (1 preparation unit is 1000g granules or 1000ml oral liquid, the recommended dosage of ciprofloxacin lactate is generally twice as much as 40-80g), and some even use three times the amount to play a certain therapeutic effect, so that blind medication will not only cause drug residues in meat food, but also affect people's health

Method used

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  • Medicinal composition for treating pullorum disease and preparation method thereof
  • Medicinal composition for treating pullorum disease and preparation method thereof
  • Medicinal composition for treating pullorum disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A pharmaceutical composition for treating pullorum, which is prepared from the following raw materials: 700g of Andrographis paniculata, 300g of Sophora flavescens, and 40g of ciprofloxacin lactate.

[0025] The preparation method of oral liquid preparation: get Andrographis paniculata, Sophora flavescens, add 8L water vacuum dynamic extraction (vacuum dynamic extraction temperature is 60 ℃, and vacuum degree is 0.1Mpa, and time is 4h), filters, and the filtrate is concentrated to a relative density of 1.12( Add 95% ethanol to the concentrated solution at 70°C until the alcohol content is 70% (volume percentage), refrigerate at 4°C for 18 hours, and recover the ethanol by vacuum distillation of the supernatant, add purified water to make up to 1000ml, add lactic acid cyclopropane Floxacin and 1 g of sodium benzoate were stirred evenly, filtered, filled, and sterilized to obtain the oral liquid preparation of the pharmaceutical composition.

[0026] The preparation metho...

Embodiment 2

[0028] A pharmaceutical composition for treating pullorum, which is prepared from the following raw materials: 600g of Andrographis paniculata, 200g of Sophora flavescens, and 80g of ciprofloxacin lactate.

[0029] The preparation method of the oral liquid preparation: take Andrographis paniculata and Sophora flavescens, add 4.8L water for vacuum dynamic extraction (vacuum dynamic extraction temperature is 50°C, vacuum degree is 0.08Mpa, time is 6h), filter, and the filtrate is concentrated to a relative density of 1.13 (70°C) concentrated solution, add 95% ethanol to the alcohol content of 50% (volume percentage), refrigerate at 4°C for 12 hours, after the supernatant is distilled under reduced pressure to recover ethanol, add purified water to make up to 1000ml, add lactic acid ring Profloxacin and 0.5 g of potassium sorbate were stirred evenly, filtered, filled, and sterilized to obtain the oral liquid preparation of the pharmaceutical composition.

[0030] The preparation ...

Embodiment 3

[0032] A pharmaceutical composition for treating pullorum, which is prepared from the following raw materials: 800g of Andrographis paniculata, 400g of Sophora flavescens, and 60g of ciprofloxacin lactate.

[0033] The preparation method of oral liquid preparation: get Andrographis paniculata, Sophora flavescens, add 12L water vacuum dynamic extraction (vacuum dynamic extraction temperature is 80 ℃, and vacuum degree is 0.09Mpa, and time is 5h), filters, and the filtrate is concentrated to a relative density of 1.15( Add 95% ethanol to the concentrated solution at 70°C until the alcohol content is 60% (volume percentage), refrigerate at 4°C for 24 hours, recover the ethanol by distillation under reduced pressure in the supernatant, add water to make up to 1000ml, add ciprofloxacin lactate 1. 2 g of benzoic acid, stirred evenly, filtered, filled, sterilized to obtain the pharmaceutical composition oral liquid preparation.

[0034] The preparation method of the granular preparat...

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Abstract

The invention belongs to the technical field of pullorum disease treatment and discloses a medicinal composition for treating pullorum disease and a preparation method thereof. The medicinal composition is prepared from the following raw material medicaments: 600 to 800 grams of common andrographis herb, 200 to 400 grams of lightyellow sophora root and 40 to 80 grams of ciprofloxacin lactate. In the invention, the ciprofloxacin lactate is directly added in an recommended amount to produce a remarkable treatment pullorum disease effect together with the common andrographis herb and lightyellow sophora root; and the ciprofloxacin lactate has high antibacterial activity, so the germ medicament resistance problem, which becomes increasingly serious nowadays, is solved. The medicament of the invention has the advantages that: the medicament materials are widely available and cheap; extraction solvent, which is water, is cheap; harm to chickens is avoided; the clinic symptoms of chickens infected with pullorum disease by human can be controlled effectively; and death rate of chickens is reduced obviously.

Description

technical field [0001] The invention belongs to the technical field of pullorum treatment, in particular to a pharmaceutical composition for treating pullorum and a preparation method thereof. Background technique [0002] Pullorum pullorum is a multiple infectious disease caused by Salmonella pullorum pullorum, which can occur in chickens of all ages. The onset of chicks shows the course of acute sepsis, which is characterized by fever, grayish white porridge or viscous liquid feces. The pathogenesis of Salmonella pullorum in adults is characterized by chronic or recessive infection that mainly damages the reproductive system. With the development of my country's poultry industry, pullorum has increasingly become one of the serious infectious diseases that endanger the poultry industry. At present, the overall drug resistance rate of Salmonella bacteria to antibiotics is between 1.4% and 90%. Antibiotics have developed high drug resistance, and resistance to fluoroquinol...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K9/00A61K9/16A61P31/04A61K31/496
Inventor 焦黎
Owner HENAN XINZHENGHAO BIO ENG
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