65results about How to "Unique mechanism of action" patented technology

The invention provides o-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as a preparation method and applications thereof in preparing medicines or functional food for preventing and / or treating tumors and other abnormal proliferation diseases of organisms and in preparing medicines or functional food for preventing and / or treating inflammations, pains and other diseases of organisms.

The invention discloses a preparation method of capsicine micro spheres, which comprises the following steps: (1) dissolving capsicine and carrier materials into an organic solvent to obtain an oil phase according to the mixing ratio of 100 to 250 mg / 27 to 100 mg / 2 to 5 mL; (2) dissolving emulsifying agents into water as a water phase, wherein the concentration of the emulsifying agents in the water phase is between 5 and 30 mg / mL; and (3) adding the oil phase into the water phase for forming oil-in-water latex emulsion according to the volume ratio of 1 / 20 to 1 / 40 under the conditions of the temperature between 20 and 30 DEG C and the stirring speed between 500 and 1200 rpm, continuously stirring the oil-in-water latex emulsion for volatilizing the organic solvent, carrying out centrifugation for collecting micro spheres, washing the micro spheres by distilled water, and preparing the capsicine micro spheres through freeze drying. The capsicine micro spheres prepared by the method of the invention can be made into various slow-release preparations, the stimulation of the capsicine can be reduced, and the medicine concentration can be maintained for a long time, so the medication times can be reduced, the toxic and side effect can be reduced, and the adaptability of patients can be improved.

The invention relates to medical applications of wedelolactone and derivatives thereof, in particular to the applications in preparing medicines for treating T-cell mediated immunologic injury diseases (chronic hepatitis or autoimmune hepatitis). Traditional Chinese Medicine eclipta has a function of liver protection; wedelolactone is prepared after the active ingredient of eclipta is traced and separated, so the pharmaceutical function is proved to be produced by wedelolactone; the structure of wedelolactone is determined through the spectrum properties and physicochemical properties. Wedelolactone is provided with biological activities: high selective inhibition to ConA stimulated T lymphocyte proliferation, no inhibition to normal peripheral blood lymphocyte (NPBL), and no cytotoxicity; wedelolactone is the active ingredient of Traditional Chinese Medicine with liver protection function; the method for preparing a novel medicine from the active ingredient of eclipta, wedelolactone, has the advantages of discarding the dross and selecting the essential, clear medicinal ingredients, definite function, safety and effectiveness, controllable quality, reducing the adverse drug reaction, and can be suitable for mass production.

The invention discloses a derivant of kutkin with chemical structural formula as formula I, wherein R1 is NO2, NH2 or amide; R2 is H, carbonyl or diaminocarbonyl. The preparing method comprises the following steps: nitrating kutkin to obtain kutkin derivant substituted by nitro group or kutkin derivant based on substituted nitro group; or kutkin derivant substituted by acetylamino.

A bichia methanol saccharomyces expressing recombinant swine lactoferrin and its peptide are disclosed. It includes: amplifying LF gene, constructing and identifying recombinant saccharomyces expressing carrier, sieving and detecting PMAD11 or PMAD16 and Ade+Muts phenotypic conversion, inducing expressing Ade+Muts strain, purifying and identifying objective protein, transferring into fermenter to grow after identifying. It achieves simple process and high purity for feed additives.

A kind of insecticide composite, mainly contains imidacloprid and buprofezin. It can be manufactured to wettable powder and miero emulsion type etc. The present invention has special preventing and killing effect to flying louse on rice. At the same time, it has better preventing and killing effect to thrips, cabbage caterpillar, diamond back moth, white loose, scale insect, peach fruit borer, red spider, bollworm, pink boll worm, etc. on vegetable, fruit tree, and cotton plant. The invention has high efficiency, low cost, little pollution.

The invention relates to the technical field of polypeptide pharmaceutical preparations, and in particular relates to a pharmaceutical composition containing polypeptides F1 and F3 and application of the pharmaceutical composition in treatment of HPV infected diseases. The content of the polypeptides F1 and F3 or a mixture of the two polypeptides is 3-30 mu g in every part of the pharmaceutical composition, and the composition is prepared into multiple conventional dosage forms such as emulsion, ointment preparations and the like and is used for treating easily reoccurring diseases caused by the HPV infection, such as condyloma acuminate, cervical cancer, carcinoma of vulva, carcinoma of penis, anal carcinoma, carcinoma of mouth and the like. The pharmaceutical composition disclosed by the invention has the advantages of short usage course of treatment, small active ingredient amount, exact curative effects, low reoccurrence rate, small side effects, low treatment cost and the like, and brings an excellent therapy pathway to patients.

The invention discloses indoxacarb water suspension concentrate and a method for preparing the same. The indoxacarb water suspension concentrate comprises, by weight, 10-25% of indoxacarb active compounds, 2-7% of dispersing agents, 1-7% of wetting agents, 1-5% of additional suspension concentrate, 1-8% of emulsifiers, 1-5% of thickeners, 0.5-5% of defoaming agents, 1-8% of antifreezing agents, 0.5-5% of preservatives, 0.5-5% of pH (potential of hydrogen) regulators and the balance water. The indoxacarb water suspension concentrate and the method have the advantages that the water suspension concentrate prepared by the aid of the method is free of dust, low in toxicity and safe for operators and users, optional organic solvents are omitted, and accordingly problems of flammability, explosiveness and intoxication during production can be solved; the water is used as a medium, so that environmental pollution can be reduced, and the indoxacarb water suspension concentrate is low in cost; the indoxacarb water suspension concentrate which is a pesticide preparation conforms to the high-content and environment-friendly preparation processing trend, is a pollution-free pesticide and accordingly has a broad application prospect.

The invention discloses a traditional Chinese medicine body shaping slimming sticker and a preparation method thereof. The traditional Chinese medicine body shaping slimming sticker comprises a back lining layer, a viscose layer and an anti-sticking protective layer, wherein the back lining layer is made of non-woven cloth; the viscose layer comprises plant essential oil, a medical pressure sensitive adhesive, a penetration enhancer and magnetic sheets. The traditional Chinese medicine body shaping slimming sticker is convenient in use, has no toxic and side effects, and has obvious treating effect for patients with simple obesity.

The invention discloses a traditional Chinese medicine composition for treating three-high diseases and a preparation method therefor. The traditional Chinese medicine composition comprises the following raw materials: red sage root, pseudo-ginseng, radix polygoni multiflori, haws, wolfberries and cassia seeds. The traditional Chinese medicine composition can be prepared into any common oral administration dosage form or health product, has functions of promoting blood circulation to remove blood stasis, benefiting liver and kidney, raising internal organ functions and promoting metabolism, and can lower blood glucose and blood fat and inhibit blood medicine rise. The traditional Chinese medicine composition has substantial curative effects of treating hypertension, hyperlipidemia and diabetes, the total effective rate for three-high diseases can reach more than 90% and no rebound is generated after the medicine is stopped. The Traditional Chinese medicine composition has minimal side effects and can be taken for a long time.

The invention provides a herbicide mixture and its preparation method and application method. The herbicide mixture comprises, in mass percent, 1 to 75% of clacyfos, 1 to 20% of carfentrazone-ethyl and an accessory. The preparation method is to mix and process 1 to 75 parts by weight of clacyfos, 1 to 20 parts by weight of carfentrazone-ethyl and the balance of the accessory. The herbicide mixture is applied when wheat is in a period from trefoil stage before winter or from returning green stage to jointing stage and when broadleaf weeds are in a seedling stage. The invention relates to the clacyfos and carfentrazone-ethyl binary herbicide mixture used for controlling broadleaf weeds in wheat fields and its preparation method and application method; the herbicide mixture in the invention has the advantages of a simple production process, a good effect, broad weed control spectrum, special efficacy on broadleaf weeds, no harm to wheat, no influence on succeeding crops, low control cost, convenient usage and capacity of reducing pollution to environment and influence on health of human bodies.

The invention discloses a binary compound herbicide in a wheat field and a using method thereof. Lvxiancaolin which is insensitive to gramineous crops and not serious in drift and tribenuron-methyl which has a good control effect against broadleaf weeds are taken as active ingredients, and the weight ratio of the two is(60:1)-(1:1); and the binary compound herbicide is applied from the period of seedling establishment to the shooting period of wheat and during the seedling period of descurainia sophia and other weeds, has the advantages of application of the herbicide during the optimum periods, small using quantity and significant compound synergy, and can improve the effect of preventing and removing the descurainia sophia and other weeds in the wheat field, increase safety and reduce the harm of the herbicide.

The invention discloses an anti-hepatofibrosis traditional Chinese medicament composition and a preparation method thereof. The anti-hepatofibrosis traditional Chinese medicament composition is prepared by the following raw materials: bear gall powder, red sage root, curcumin and milk veteh. The anti-hepatofibrosis traditional Chinese medicament composition prepared by the preparation method can be prepared into any commonly used oral administration preparation, has obvious effects on treating hepatofibrosis, hepatitis, fatty liver, hepatocirrhosis and the like and has obvious medicament functions for protecting the liver, reducing aminotransferase and inhibiting the fibrosis of stem cells.

The invention discloses a traditional Chinese medicine composition removing oral malodor and a preparation method therefor. The traditional Chinese medicine composition comprises the following raw materials: eupatorium, clove, fructus amomi and mint. The traditional Chinese medicine composition can be prepared into any common oral administration dosage form or health product, and has functions of clearing heat and fire, smoothing circulation, resolving dampness and expelling turbid. The plurality of traditional Chinese medicines cooperate with each other, and mutual cooperation synergy of the active ingredients removes oral malodor effectively. The composition has functions of sterilization and oral health care, and eliminates oral malodor caused by various factors rapidly. Oral breath is fresh and lasting after the composition is used. The composition has substantial curative effects of removing oral malodor, has no toxic or side effects, and can be taken for a long time.

The invention particularly discloses a method for delaying the leaf falling of a plum tree in autumn and winter. The method mainly comprises the following steps: (1) preparing a delayer, wherein the delayer for maiden trees comprises 25% of biogas slurry, 0.3% of monopotassium phosphate, 0.05% of spinetram and 0.2% of a high-fat membrane, and the delayer for a full-grown tree comprises 25% of biogas slurry, 0.3% of urea, 0.05% of spinetram and 0.2% of a high-fat membrane; and (2) spraying the delayer at different periods, namely, spraying the delayer for the first time after plum fruits are harvested within 10-15 days, spraying the delayer for the second time after the first-time delayer spraying for 15-20 days, and spraying the delayer for the third time after the second-time delayer spraying for 30-45 days. By adopting the method, the fertilizer and pesticide utilization rate can be increased, and the 'medicine-fertilization integration' is realized. The method shows the good interaction synergy; the fertilizer efficiency is improved by 8%-15%; the pesticide effect is improved by 22%-30%; the problem of natural mutual contact and reduction of pesticides in use with the fertilizers is overcome.

The invention discloses a pesticide. The pesticide is composed of a main agent and an auxiliary agent. The ingredients of the main agent are: acetamiprid 10.0-20.0wt%, acephate 15.0-30.0wt%; the auxiliary agent Including 25.0-45.0wt% ethanol, 3.0-16.0wt% benzyl polyphenol polyoxyethylene ether, 2.0-10.0wt% Tween-80, 2.0-5.0wt% pyrrolidone, 1.0-4.0wt% p-nitrobenzoic acid, 0.5-4.0wt% propyl gallate, wherein the mass fraction of each substance is relative to the total mass of the pesticide. For the pesticide disclosed by the present invention, acetamiprid and acephate are mixed according to a suitable ratio, and suitable auxiliary agents are added as auxiliary agents, and pesticides in the forms of emulsifiable concentrate, microemulsion, and water emulsion can be prepared according to the usual methods. It has the characteristics of good insecticidal effect, long-lasting drug effect, and little harm to humans and other animals.

The invention provides a prescription and a preparation process for an irinotecan hydrochloride injection. The preparation process comprises the following steps: weighing and re-checking; preparation of a soup; removal of bacteria through filtration; sterile filling; and terminal sterilization. The invention is characterized in that since the process employs rotating water-bath for terminal sterilization, fast production is realized, the amount of related substances can be effectively controlled, the period of validity is prolonged and irinotecan hydrochloride in the injection is allowed to be more stable.

The invention discloses a compound sterilizing agent and application thereof. The compound sterilizing agent consists of fluopicolide and fludioxonil with the mass ratio of (1-9): (1-9), the preferred mass ratio of (1-7): (1-5) or the more-preferred mass ratio of (1-5): (1-3). The compound sterilizing agent can be used for preventing and treating plant diseases such as vegetable downy mildew, late blight, gray mold, cucumber root rot and pepper phytophthora blight. The compound sterilizing agent disclosed by the invention is good in quick acting and persistence, has a unique action mechanism, more action sites and a wide bacteriocidal spectrum, is high in biosafety, simple in preparation process and low in cost and has obvious economic benefits.

The invention relates to insect killing and fertilizer effect integrated biological insecticide which comprises the following ingredients by weight percentage: 15-35% of chitin, 5-25% of calcium ion powder, 1-10% of neem seed oil, 1-10% of mandarin oil, 15-35% of sodium lauroyl sarcosine, 1-4% of citric acid and the balance of deionized water. The insect killing and fertilizer effect integrated biological insecticide and the preparation method have the characteristics of convenient material drawing, low cost, long control period, high efficiency, economy, good safety, no pollution, high environment compatibility and the like.

The invention belongs to the technical field of pesticides, and relates to a weeding composition. The weeding composition is characterized by comprising three active ingredients of halauxifen-methyl, carfentrazone-ethyl and fluroxypyr. The weeding composition has the advantages that the weeding spectrum is broad, the weeding effect is obvious, the safety of crops is realized, the lasting period is prolonged, and the synergistic function is obvious.

The invention belongs to the technical field of pullorum disease treatment and discloses a medicinal composition for treating pullorum disease and a preparation method thereof. The medicinal composition is prepared from the following raw material medicaments: 600 to 800 grams of common andrographis herb, 200 to 400 grams of lightyellow sophora root and 40 to 80 grams of ciprofloxacin lactate. In the invention, the ciprofloxacin lactate is directly added in an recommended amount to produce a remarkable treatment pullorum disease effect together with the common andrographis herb and lightyellow sophora root; and the ciprofloxacin lactate has high antibacterial activity, so the germ medicament resistance problem, which becomes increasingly serious nowadays, is solved. The medicament of the invention has the advantages that: the medicament materials are widely available and cheap; extraction solvent, which is water, is cheap; harm to chickens is avoided; the clinic symptoms of chickens infected with pullorum disease by human can be controlled effectively; and death rate of chickens is reduced obviously.

The invention discloses a nitenpyram and pyridaben containing pesticide composite, in which the pbm (parts-by-mass) ratio of nitenpyram to pyridaben is (1:20)-(20:1). A compound of the two effective components has an obvious synergistic effect, so that the control efficiency is improved, the control spectrum is expanded, and the dosages of the pesticides are reduced, thereby reducing the cost and the pollution to the environment. The pesticide composite disclosed by the invention is suitable to be used for preventing and controlling various pests such as aphids, plant hoppers, thrips, whiteflies and red spiders of crops such as vegetables, paddy rice and fruit trees.

A sucralfate self-emulsifying microcapsule is composed of solid powder or particles prepared from sucralfate, lipid, surfactant, and a wall material; the capsule core is composed of a sucralfate self-emulsifying composition, and the capsule core is wrapped by a wall material. The microcapsule is prepared through a spray drying method and a spray-coagulation method. The provided microcapsule is a novel upper digestive tract mucosa protective agent. The microcapsule has the advantages of wide range of indication, more unique and comprehensive action mechanism, and no prominent clinical side effect. Moreover, the frequency of daily drug taking is reduced by 50%, compared with conventional dosage forms. The microcapsule is user-friendly. The compliance of patients is increased, and the microcapsule is beneficial for more clinical patients. The particles in microcapsule are small, have a self-emulsifying function, are not affected by the gastrointestinal functions of patients, and can be well absorbed, and thus a good treatment effect can be achieved. The microcapsule is especially suitable for children, the old, and the patients, who have bad gastrointestinal functions, and can reduce the burden on stomach and intestines.

The invention discloses a compound bactericide and an application thereof. The compound bactericide is prepared from mandipropamid and fludioxonil, and the mass ratio of mandipropamid to fludioxonil is (1-9): (1-90), preferably (1-5):(1-5), and more preferably (1-3):1. The compound bactericide is applicable to prevention of vegetable downy mildew, late blight, botrytis, cucumber root rot, pepper phytophthora blight and other plant diseases. The fast-acting property and the persistence of the compound bactericide are good, the mechanism of action is unique, the acting sites are more, the bacteriocidal spectrum is wide, the biosecurity is high, the preparation process is simple, the cost is low, and the economic benefit is remarkable.

The invention discloses a sterilizing composition containing fludioxonil and metalaxyl, a preparation method thereof, and an application thereof. The sterilizing composition is characterized in that: the sterilizing composition comprises fludioxonil, metalaxyl, and other auxiliary agents. A weight ratio of fludioxonil to metalaxyl is 70:1-1:60. The sterilizing composition can be used for controlling paddy rice blast. The sterilizing composition has advantages of low cost and good effect. No report about fludioxonil and metalaxyl blending is found home or abroad. Therefore, the invention is provided.

The invention is a method of producing all-pupa powder containing lactoferrin and its peptide, adopting bacilliform viruses as carrier, and using silkworm pupas as host to produce the gene engineering product with the bioactivity similar to that of the natural lactoferrin and the corresponding peptide. The producing and using course is safe and has no latent danger to human beings and animals and the environment. The all-pupa powder acting as feed additive can supplement feed proteins and simultaneously play a role in sterilizing and resisting viruses, and enhancing self-immunity of animals, and can effectively prevent and cure the diarrhea of weaner piglets, thus producing a high-quality animal product without residual antibiotics.

The invention discloses an anti-hepatofibrosis traditional Chinese medicament composition and a preparation method thereof. The anti-hepatofibrosis traditional Chinese medicament composition is prepared by the following raw materials: bear gall powder, red sage root, curcumin and milk veteh. The anti-hepatofibrosis traditional Chinese medicament composition prepared by the preparation method can be prepared into any commonly used oral administration preparation, has obvious effects on treating hepatofibrosis, hepatitis, fatty liver, hepatocirrhosis and the like and has obvious medicament functions for protecting the liver, reducing aminotransferase and inhibiting the fibrosis of stem cells.

The invention belongs to the technical field of pesticides and relates to a pesticide composition comprising metacrate and pymetrozine, wherein the weight ratio of the metacrate to the pymetrozine is (9:1)-(1:1). The pesticide composition can be prepared into various known dosage forms. The pesticide overcomes the resistance of the pests to organic nitrogen by utilizing the synergistic action of the metacrate and the pymetrozine and has obvious prevention and cure effects on insects resisting to the organic nitrogen, such as lesser green leaf hoppers, rice plant hoppers, and the like.