Sucralfate self-emulsifying microcapsule and preparation method thereof

A sucralfate and self-emulsifying technology is applied in the field of new dosage forms of anti-peptic ulcer drug sucralfate, which can solve the problems of many excipients, poor dosage form stability, adverse effects on drug safety, etc., and achieves increased absorption and good stability. , the effect of improving bioavailability

Inactive Publication Date: 2016-02-03
KUNMING JIDA PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems of less types of sucralfate drug dosage forms, more excipients used in the existing ones, easy to have adverse effects on the safety of medicines, and poor stability of dosage forms such as pellets and tablets, etc., and provide a Technical scheme of sucralfate self-emulsifying microcapsule and preparation method

Method used

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  • Sucralfate self-emulsifying microcapsule and preparation method thereof
  • Sucralfate self-emulsifying microcapsule and preparation method thereof
  • Sucralfate self-emulsifying microcapsule and preparation method thereof

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Embodiment Construction

[0036] 1. Preparation method of instant sucralfate self-emulsifying microcapsules

[0037] Adopt spray drying method, concrete parameter sees 1-5 of table 1, concrete steps are as follows:

[0038] (1) Prepare raw materials: Prepare materials according to the following proportions in parts by mass: sucralfate: lipid: surfactant: wall material = 1-20: 5-30: 5-30: 30-90;

[0039] in:

[0040] The lipid is at least one of lemon oil, orange oil, tangerine peel oil, peppermint oil, fennel oil, medium chain oil, ethyl oleate, propylene glycol dicaprylate dicapric acid;

[0041] The surfactant is at least one of polyoxyethylene castor oil EL35, polyoxyethylene castor oil EL40, polyoxyethylene hydrogenated castor oil RH40, and Tween 80;

[0042] The wall material is an instant material, including sucrose, glucose, lactose, fructose, mannose, trehalose, maltose, see Table 1 recipe 1-5; modified starch, dextrin or sorbitol can also be used;

[0043] (2) Add sucralfate and lipid into th...

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Abstract

A sucralfate self-emulsifying microcapsule is composed of solid powder or particles prepared from sucralfate, lipid, surfactant, and a wall material; the capsule core is composed of a sucralfate self-emulsifying composition, and the capsule core is wrapped by a wall material. The microcapsule is prepared through a spray drying method and a spray-coagulation method. The provided microcapsule is a novel upper digestive tract mucosa protective agent. The microcapsule has the advantages of wide range of indication, more unique and comprehensive action mechanism, and no prominent clinical side effect. Moreover, the frequency of daily drug taking is reduced by 50%, compared with conventional dosage forms. The microcapsule is user-friendly. The compliance of patients is increased, and the microcapsule is beneficial for more clinical patients. The particles in microcapsule are small, have a self-emulsifying function, are not affected by the gastrointestinal functions of patients, and can be well absorbed, and thus a good treatment effect can be achieved. The microcapsule is especially suitable for children, the old, and the patients, who have bad gastrointestinal functions, and can reduce the burden on stomach and intestines.

Description

technical field [0001] The invention relates to a new dosage form of an anti-peptic ulcer drug sucralfate, in particular to a sucralfate self-emulsifying microcapsule and a preparation method thereof. Background technique [0002] Sucralfate is an effective anti-peptic ulcer drug, which can protect the ulcer surface and promote ulcer healing. Sucralfate can dissociate sucrose sulfate compound ions in an acidic environment, and the compound ions can polymerize into insoluble negatively charged colloids, which can combine with positively charged protein exudates on the ulcer surface to form a protective film covering the Ulcer surface, promote ulcer healing. It also has the function of adsorbing pepsin and bile acid; promoting the synthesis of endogenous prostaglandins and adsorbing epidermal growth factor, making it concentrated in ulcers and conducive to mucosal regeneration. [0003] Sucralfate is insoluble in water, and the bioavailability of oral administration is low...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/7024A61P1/04
Inventor 李家伟刘建彤张云
Owner KUNMING JIDA PHARMA
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