The invention discloses a compound preparation used for treating radiation bone injuries and a preparing method thereof.The compound preparation comprises calcium gluconate, monofluorophosphate glutamine, rocaltrol, nafcillin, oxacillinum natricum, durabolin, glutathione, calcitonin, icariin, vitamin AD, stanozolol, corticosteroid, sucralfate, dexamethasone and lipopolysaccharide.The compound preparation has the effects of resisting radiation, enhancing immunity and promoting bone cell metabolism, can effectively prevent complications such as radiation osteoporosis, radiation marrow, radiation fracture, osteoradionecrosis and radiation dysostosis, the formula of the compound preparation is novel and unique, the curative effect is good, cost is low, the side effect is small, and the compound preparation is widely suitable for the radiation bone injuries.