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Helicobacter pylori eliminating oral liquid and preparation method thereof

An oral liquid and quiet technology, applied in the field of oral liquid, can solve the problem that the specific IgY against Helicobacter pylori is not very significant, and achieve the effect of maintaining long-term high activity, avoiding cross-reaction, and remarkable effect

Inactive Publication Date: 2016-12-07
SICHUAN VACCINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to solve the problem that the effect of the existing anti-Helicobacter pylori specific IgY directly used in the treatment of Hp infection is not very significant, to provide a Qingyou oral liquid with good effect in the treatment of Hp infection, and to provide the oral liquid The preferred preparation method of

Method used

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  • Helicobacter pylori eliminating oral liquid and preparation method thereof
  • Helicobacter pylori eliminating oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1.1 The specific preparation method of oral liquid

[0030] Prepare a sucralfate solution with a mass concentration of 40%, and then mix the sucralfate solution and the yolk antibody in equal volumes. At this time, the final concentration of sucralfate is 20%. After sealing, it can be sterilized in a water bath at 65°C for 30 minutes. Wherein, the concrete preparation method of the egg yolk antibody in the present embodiment is as follows:

[0031] Step 1. Select 3-4 month old Laihang laying hens, and use CTB adjuvant for multi-point injection on the leg muscles of laying hens. The injection amount of this CTB adjuvant is 0.4 mg / bird.

[0032] Step 2. One week after CTB adjuvant injection, IB is used to immunize laying hens more than once; in this embodiment, the number of times IB is used for immunization is four times, namely the first immunity, the second immunity, the third immunity and the fourth immunity. , the immunization interval between the first, second, thi...

Embodiment 2

[0075] 2.1 The specific preparation method of oral liquid

[0076] The difference between this embodiment and the oral liquid in Example 1 is only that: the preparation method of egg yolk protein in this embodiment is different, and the specific preparation method of this egg yolk protein in this embodiment is as follows:

[0077] Step 1. Select 3-4 month old Laihang laying hens, use whole bacterial protein as immune protein to immunize Laihang laying hens more than once, and the whole bacterial protein is inactivated Helicobacter pylori Sydney strain (H. pylori). ss1); In the present embodiment, the number of times that the whole bacterial protein is used to immunize is four times, which are respectively the first immunity, the second immunity, the third immunity and the fourth immunity, and the immunization time interval between the first immunity, the second immunity, the third immunity and the fourth immunity is: On the 14th day, the injection volume of the first immune sy...

Embodiment 3

[0083] The preparation of the oral liquid in this example is basically the same as that in Example 1, and the difference between this example and Example 1 is only that the amount of sucralfate added in this example is 10% of the final volume of the oral liquid.

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Abstract

The invention discloses helicobacter pylori eliminating oral liquid and a preparation method thereof. The helicobacter pylori eliminating oral liquid comprises egg yolk antibody and sucralfate solution, the egg yolk antibody and sucralfate solution are mixed in equal volume, and a final mass concentration of sucralfate is 10%-30%. The helicobacter pylori eliminating oral liquid and the preparation method thereof have advantages that excellent Hp infection treatment effects are achieved, and the problem that existing helicobacter pylori resisting specific IgY directly used for Hp infection treatment is not remarkably effective is solved.

Description

technical field [0001] The invention relates to an oral liquid, in particular to a Qingyou oral liquid, that is, a specific anti-Helicobacter pylori oral liquid, and provides a specific preparation method of the oral liquid. Background technique [0002] Helicobacter pylori (H. pylori, Hp for short) is a pathogen with the highest infection rate in the world, living in various regions of the stomach and duodenum. It can cause mild chronic inflammation of the gastric mucosa, or even lead to gastric and duodenal ulcers and gastric cancer. It has been recognized as one of the most common pathogens of chronic infectious diseases. At present, triple or quadruple therapy is the main means of clinical treatment of H. pylori infection, but with the increase of drug resistance rate, the cure rate of triple or quadruple therapy is getting lower and lower, so it is particularly important to develop specific and targeted therapy drugs . [0003] Specific egg yolk antibody (egg yolk imm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/12C07K16/02A61K39/40A61K9/08A61K47/02A61P31/04
CPCC07K16/121A61K9/08A61K2039/505C07K2317/11
Inventor 张勇王勇祝洁周永君
Owner SICHUAN VACCINE TECH
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