The invention relates to a vitamin U belladonna aluminum dispersible tablet and its preparation process, belonging to the field of medical technology, and specifically relates to the improvement of the preparation process of vitamin U belladonna aluminum; vitamin U II, aluminum hydroxide, and belladonna extract are used as raw materials, and starch is used as a filler , adding microcrystalline cellulose, sodium carboxymethyl starch, talcum powder, and magnesium stearate to make dispersible tablets. The process is: take vitamin U II and aluminum hydroxide, pulverize them separately, and sieve them; Sieve preparation; sieve belladonna extract and appropriate amount of starch; sieve and mix with internally added auxiliary materials and mix uniformly by equal incremental method; make the above mixture into soft material with 10% starch slurry, and granulate with sieve; hot air drying ; sieve and mix with additional auxiliary materials, tabletting; the vitamin U belladonna aluminum dispersible tablet produced by the present invention has a fast disintegration speed compared with the original capsule, shortened to three minutes from 30-60 minutes of the original capsule , the disintegration speed is increased by 10-20 times, and the time to reach the peak blood concentration of the drug is also relatively shortened, so that the new drug of the present invention has a faster onset of effect and a more definite curative effect.