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Sucralfate-colloidal bismuth pectin compound pharmaceutical tablets and preparation method thereof

A technology of colloidal bismuth pectin and sucralfate, which can be used in drug combination, pill delivery, and pharmaceutical formulations, can solve the problems of severe gastrointestinal reactions and short half-life, and achieve smooth muscle spasm, inhibit gland secretion, improve Fluidity and solubility effects

Inactive Publication Date: 2016-09-07
ZHENGZHOU SIBIAN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the purpose of the present invention is to address the deficiencies in the prior art, to provide a sucralfate colloid pectin bismuth compound drug tablet and a preparation method thereof, which solves the short half-life and gastric The problem of adverse reactions such as severe intestinal reactions has also increased the antibacterial and antibiotic ingredients of traditional Chinese medicine to achieve the effect of sustained release of sucralfate and enhanced immunity

Method used

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  • Sucralfate-colloidal bismuth pectin compound pharmaceutical tablets and preparation method thereof
  • Sucralfate-colloidal bismuth pectin compound pharmaceutical tablets and preparation method thereof
  • Sucralfate-colloidal bismuth pectin compound pharmaceutical tablets and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031]A sucralfate colloidal bismuth pectin compound drug tablet, comprising the following raw materials in parts by weight: 20 parts of colloidal bismuth pectin as bismuth, 10 parts of sucralfate as aluminum, 30 parts of belladonna extract, and astragalus extract 2 parts, 2 parts of Atractylodes macrocephala extract, 2 parts of Fangfeng extract, 5 parts of Radix Radix Radix, 20 parts of hypromellose phthalate, 3 parts of microcrystalline cellulose, 15 parts of low-substituted hydroxypropyl cellulose 2 parts of magnesium stearate and 0.1 part of glycyrrhizin.

[0032] Its preparation method comprises the following steps:

[0033] 1) Grinding and manufacturing pellet cores: Grinding colloidal bismuth pectin, sucralfate, and belladonna extract, drying, and centrifuging to granulate to obtain the first pellet core. , Radix isatidis extract, pulverized and passed through a 250-mesh sieve, then mixed evenly, and centrifugally granulated to obtain the second pellet core;

[0034] ...

Embodiment 2

[0039] A sucralfate colloidal bismuth pectin compound drug tablet, comprising the following raw materials in parts by weight: 60 parts of colloidal bismuth pectin as bismuth, 20 parts of sucralfate as aluminum, 40 parts of belladonna extract, and astragalus extract 40 parts, 40 parts of Atractylodes macrocephala extract, 40 parts of Fangfeng extract, 80 parts of Radix Radix Radix, 30 parts of hypromellose phthalate, 5 parts of microcrystalline cellulose, 30 parts of low-substituted hydroxypropyl cellulose parts, 3 parts of magnesium stearate and 0.2 parts of glycyrrhizin.

[0040] Its preparation method comprises the following steps:

[0041] 1) Grinding and manufacturing pellet cores: Grinding colloidal bismuth pectin, sucralfate, and belladonna extract, drying, and centrifugally granulating to obtain the first pellet core; 1. The Radix isatidis extract is pulverized and passed through a 300-mesh sieve, then mixed evenly, and centrifugally granulated to obtain the second pel...

Embodiment 3

[0047] A sucralfate colloidal bismuth pectin compound drug tablet, comprising the following raw materials in parts by weight: 35 parts of colloidal bismuth pectin as bismuth, 16 parts of sucralfate as aluminum, 35 parts of belladonna extract, and astragalus extract 30 parts, 30 parts of Atractylodes macrocephala extract, 30 parts of Fangfeng extract, 60 parts of Radix Radix Radix, 25 parts of hypromellose phthalate, 3 parts of microcrystalline cellulose, 20 parts of polyethylene glycol, hard 2 parts of magnesium fatty acid and 0.1 part of stevia.

[0048] Its preparation method comprises the following steps:

[0049] 1) Grinding and manufacturing pellet cores: Grinding colloidal bismuth pectin, sucralfate, and belladonna extract, drying, and centrifugally granulating to obtain the first pellet core; 1. The Radix isatidis extract is pulverized and passed through a 270-mesh sieve, then mixed evenly, and centrifugally granulated to obtain the second pellet core;

[0050] 2) Pre...

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Abstract

The invention discloses sucralfate-colloidal bismuth pectin compound pharmaceutical tablets and a preparation method thereof. The sucralfate-colloidal bismuth pectin compound pharmaceutical tablets are prepared from, by weight, 20-60 parts of colloidal bismuth pectin (in bismuth), 10-20 parts of sucralfate (in aluminum), 30-40 parts of a belladonna extract, 20-40 parts of a milkvetch root extract, 20-40 parts of a langehead atractylodes rhizome extract, 20-40 parts of a radix saposhnikoviae extract, 50-80 parts of a radix isatidis extract, 25-30 parts of a coating agent, 3-5 parts of a disintegrating agent, 15-30 parts of a bonding agent, 2-3 parts of an excipient and 0.1-0.2 part of a corrective agent. According to the sucralfate colloidal bismuth pectin compound pharmaceutical tablets, by cooperatively using colloidal bismuth pectin and sucralfate, protection on the gastric mucosa is enhanced, and the pharmacological efficacy is improved; the traditional Chinese medicine extracts serve as an antibacterial and antiviral agent and can achieve the immunity regulating effect, enhance the immunity of the organism and decrease the disease relapse rate.

Description

technical field [0001] The invention relates to a compound pectin-bismuth medicine and a preparation method thereof, in particular to a sucralfate colloid pectin-bismuth compound medicine tablet and a preparation method thereof. Background technique [0002] Colloidal bismuth pectin is a colloidal bismuth preparation, which is a salt formed by biomacromolecule pectinic acid (D-polygalacturonic acid) and metal bismuth ions and potassium ions. It has strong colloidal properties in acidic media , can form a solid protective film on the gastric mucosa, enhance the barrier protection of the gastric mucosa, so it has a good therapeutic effect on peptic ulcer and chronic gastritis, and can be used to kill Helicobacter pylori, which is beneficial to improve digestion The healing rate of ulcers and the reduction of recurrence rate have good effects on peptic ulcer, relief of symptoms of chronic gastritis, pathological improvement of chronic gastritis, and negative conversion rate of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/20A61K47/38A61P1/04A61P37/04A61K31/732A61K31/7024
CPCA61K31/732A61K9/2054A61K9/2081A61K31/7024A61K36/195A61K36/238A61K36/284A61K36/315A61K36/481A61K36/81A61K2300/00
Inventor 闵玉涛
Owner ZHENGZHOU SIBIAN TECH CO LTD
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