The invention relates to the technical field of infusion devices, and discloses an infusion bottle changing device for the emergency department. Comprising a bottom plate, a first support, a first transmission mechanism rotationally installed on the first support, a chassis, a first rotating shaft, a rotating disc, a driving motor, a pair of lead screws, a grabbing mechanism installed on the pair of lead screws, a rotating assembly installed on the chassis and a controller, and a puncture assembly is arranged on the chassis. By arranging the grabbing mechanism, two medicine bottles can be grabbed; by arranging the rotating disc, the driving motor and the pair of lead screws, the grabbing mechanism can be driven by the driving motor to move up and down along the lead screws, and the height of the grabbing mechanism is adjusted; through the rotating assembly, the rotating disc, the first rotating shaft and the pair of lead screws, on one hand, the grabbing mechanism can be driven to rotate to the position of the puncturing assembly to puncture a medicine bottle, after liquid medicine in the medicine bottle is dripped off, the grabbing mechanism can be rotated through the rotating assembly to achieve replacement of the medicine bottle, the workload of medical staff is relieved, and the working efficiency is improved.