Use of inactivated BCG vaccine in prevention or treatment of novel coronavirus-related conditions

A technology of inactivating BCG and BCG, which is applied in antiviral agents, medical preparations containing active ingredients, respiratory diseases, etc., can solve the problems of no effective research and reports on the prevention and treatment of new coronavirus infection, and improve local antiviral Effectiveness of virus, improvement of local immunity, effect of reduction of coronavirus infection

Pending Publication Date: 2020-06-09
GENEIS TECH BEIJING CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no research or report on whether BCG vaccine is effective in the prevention and treatment of the current epidemic new coronavirus infection

Method used

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  • Use of inactivated BCG vaccine in prevention or treatment of novel coronavirus-related conditions
  • Use of inactivated BCG vaccine in prevention or treatment of novel coronavirus-related conditions
  • Use of inactivated BCG vaccine in prevention or treatment of novel coronavirus-related conditions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] 1. Mouse experiment:

[0032] By inoculating BCG vaccine into mice infected with coronavirus, and observing and analyzing the survival rate of the mice, the results are as follows figure 1 shown. Depend on figure 1 It can be seen that the survival rate of mice administered with BCG was greatly improved.

[0033] In addition, experiments on the effect of BCG on tumor growth in mice were also carried out. The result is as figure 2 shown. Depend on figure 2 It can be seen that direct injection of BCG into tumor-bearing mice can enhance the anti-tumor immunity of mice and inhibit the growth of tumors.

[0034] 2. Clinical Data Analysis

[0035] Inoculate BCG vaccine to people of different ages infected with the new coronavirus, and statistically analyze the symptoms of each individual. The result is as image 3 shown. Depend on image 3 It can be seen that the disease symptoms of children with new coronary pneumonia who were vaccinated with BCG were significan...

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PUM

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Abstract

The invention discloses a use of an inactivated BCG vaccine in prevention or treatment of novel coronavirus-related conditions. The research of the invention shows that the BCG vaccine not only can prevent tubercle bacillus infection, but also is a safe immunopotentiator, has a wide protection effect on respiratory tract infection caused by the novel coronavirus, and can protect organisms from infection of the respiratory tract viruses. Through research and development of the novel application of the old vaccine, the research and development period and cost are greatly shortened, and the application is safe and effective and has important significance for the serious situation of prevention and treatment of novel coronavirus at present.

Description

technical field [0001] The present invention relates to a new application of BCG, in particular to the use of inactivated BCG for preventing or treating conditions related to the novel coronavirus. Background technique [0002] The novel coronavirus (coronavirus, or SARS-CoV-2) has become a major threat to human health and economic development. Currently, the best means of preventing the spread of the virus is mandatory quarantine and no other means of prevention. Vaccines are the most likely effective means of prevention, but it may take at least half a year or even more than two years for the successful development of vaccines to the third or fourth clinical trials. Responding to this dangerous epidemic may require a multi-pronged approach, and even unconventional means are necessary for short-term intervention in the 2019-nCoV epidemic. [0003] Bacillus Calmette-Guerin (BCG) is an inactivated vaccine of Mycobacterium bovis. As early as the 1970s, BCG vaccine has been u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/04A61K9/12A61P31/14A61P11/00A61P31/16
CPCA61K39/04A61K9/12A61P31/14A61P11/00A61P31/16A61K2039/521A61K2039/542A61K2039/543
Inventor 冷启彬邓朝阳
Owner GENEIS TECH BEIJING CO LTD
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