The invention relates to a medicament for comprehensively treating a plurality of skin diseases, which is a perfect prescription clinically tested for years and belongs to a natural traditional Chinese medicine extract. The medicament is prepared by extracting the effective components of the following traditional Chinese medicines by weight portion: 2 of calomeas, 20 of heavy sulfur powder, 20 of khosam, 30 of stemona root, 50 of radix sophorae falvescentis, 30 of quintupling shell, 10 of macrostem onion juice and 20 of purple garlic, and then sterilizing and condensing the effective components to be prepared into ointment which is known as potent skin-cleaning ointment for short and has the functions of heat and toxic material elimination, desinsection, sterilization and virus prevention; the extract liquid of astragalus root, long-nosed pit viper oil, carotene, aloe and pearl powder, which is known as lotion for short, has the functions of nourishing skin myocyte, eliminating skin ulcer, generating muscle, moisturizing and protecting the skin, resisting inflammation and improving partial immunity; and when the extract liquid is dissolved in 95-percent alcohol, the ointment and the extract liquid which are proportionally mixed can be used for external applying to treat seborrheic dermatitis, comedo, acne, scabies, impetigo, flat warts, ringworm, tinea corporis, solar dermatitis, ecthyma, and the like, has reliable curative effect in treating a plurality of recurring skin diseases, has little side effect and high cure rate and can really achieve the aim of curing a plurality of diseases with one prescription and curing a specific disease completely with one prescription.