The invention discloses a cholesterol-lowering and antithrombotic traditional Chinese medicine composition for warming channels and activating collaterals. The cholesterol-lowering and antithrombotic traditional Chinese medicine composition is prepared from the following raw materials: ligusticum wallichii, flos carthami, astragalus membranaceus, panax notoginseng, cassia twig, a red peony root, puerarin, curcuma aromatic, costustoot, hawthorn, borneol, cane sugar and dextrin. The invention further discloses a preparation method of the cholesterol-lowering and antithrombotic traditional Chinese medicine composition for warming channels and activating collaterals. The method comprises the following steps: (S1) preparing an extract: mixing taken ligusticum wallichii, flos carthami, astragalus membranaceus, red peony root, puerarin, cassia twig, curcuma aromatica, costustoot and hawthorn evenly to obtain a mixture, adding water to the mixture, decocting the mixture for three times, filtering and taking filtrate, merging the filtrate of three times and concentrating the filtrate to obtain the extract, wherein the relative density of the extract is 1.32-1.35g/ml; (S2) preparing dry panax notoginseng powder; and (S3) pelletizing: mixing the borneol, the ethanol, the dextrin, the cane sugar, the extract obtained in the step (S1) and the dry panax notoginseng powder obtained in the step (S2) evenly, preparing a soft material, pelletizing, drying, granulating, and mixing the mixture evenly to obtain the cholesterol-lowering and antithrombotic traditional Chinese medicine composition for warming channels and activating collaterals.