Total extractives of steroid saponin, prepn. method and application thereof

Abstract

The invention relates to extract of the steroid saponin produced from the yam or the yam with the guilder leaf which has the character of containing the 80%-90% the steroid saponin in the percentage by weight. The intravenous fluid produced from the extract of the steroid saponin can not only dilate the coronary, depress the myocardial oxygen consumption, melt the thrombus, improve the myocardial ischemia and the microcirculation, amend the function of the vas endothelial cell, increase the blood stream of the brain, prevent the ischemia brain cell injury, but also drop the blood pressure, the blood fat, the blood sugar; at the same time, it has the function of resisting inflammation, ease pain, codein, preventing asthma, dispelling the myospasm, improving the immunity and resisting the allergy. So it can cure the cerebrovascular, the rheumatism and the disease of the respiratory system. The invention has the good clinic extended value because of the low dosage of the active ingredient, the efficacy, the effecting quick and the high bioavailability.

Description

technical field [0001] The invention relates to a steroidal total saponin extract, a preparation method and application thereof. Background technique [0002] The traditional Chinese medicine Chuanshanlong is the dried rhizome of Dioscorea nipponica Makino, another name of Dioscorea nipponica Makino. Mainly produced in Northeast and North China. Dioscorea zingiberensis, a traditional Chinese medicine, is the rhizome of Dioscorea zingiberensis C.H.Wright, a plant of the family Dioscoreaceae. Both Chuanshanlong and Dioscorea scutellariae have the effects of dispelling rheumatism, relieving pain, relaxing tendons and activating blood circulation, relieving cough, relieving asthma and eliminating phlegm. It is clinically used to treat rheumatoid arthritis, lumbago and leg pain, numbness, Kashin-Beck disease, injury from falling, flashback, chronic bronchitis, cough and asthma and other diseases. [0003] Diosgenin Tablets (WS) in National Standard Volume 16 1 -XG-012-2000) i...

AI Technical Summary

Problems solved by technology

[0003] Diosgenin Tablets (WS) in National Standard Volume 16 1 -XG-012-2000) is an oral preparation, and the extract prepared by this method cannot be directly used as a raw material for intravenous injection; 3 -B-32) is mainly prepared by water decoction extraction and ethanol precipitation method, and the content of active ingredients in the product obtained by this method is not high; the name is "a kind of freeze-dried powder injection of Chuanshanlong and its preparation method (application number: 200410086729.1)" In the patent application, ultrasonic water extraction, ethanol precipitation, and macroporous resin purification were used to obtain the active ingredients, and pharmaceutical excipients were added to prepare freeze-dried powder injections. In this method, it is difficult to use ultrasonic extraction for large-scale production and application.

At present, there is no literature report about the method and application of steroidal total saponin extract for intravenous injection prepared from pangolin or Dioscorea scutellaria as raw materials