2 results about "Smooth muscle spasm" patented technology

Providing a controlled-release formulation containing dorotaberine or its salts, or an active substance with a similar tendency to degrade through oxidation / hydrolysis. [Solution] The present invention provides a controlled-release formulation containing dorotaberine or a salt thereof, or an active substance with a similar tendency to degrade through oxidation / hydrolysis. The present invention provides a once- or twice-daily controlled-release formulation of dorotaberine or a salt thereof that avoids fluctuations in plasma levels, reduces pill burden and side effects through a simplified dosing schedule, and consequently improves patient compliance. The present invention also provides a method for preparing a controlled-release formulation of dorotaberine or a salt thereof. The present invention further provides a controlled-release formulation of dorotaberine or a salt thereof for the treatment of at least one symptom of gastrointestinal, biliary, urinary, and gynecological disorders characterized by a spastic state of smooth muscle in a subject.

The application belongs to the field of traditional Chinese medicines, and relates to a new application of Shouhui Tongbian capsules, in particular to an application of the Shouhui Tongbian capsules in a medicine for treating ureteral reflux. It is proved by a pharmacodynamic test that the traditional Chinese medicine composition can enhance the tension and activity of ureter and ileum smooth muscles, has a very important role in relieving ureter smooth muscle spasm and expanding ureter lumen, is beneficial to the transportation of urine, has a significant anti-ureteral reflux effect, is high in safety, and has a broad application prospect and positive clinical significance.