80 results about "Smooth muscle spasm" patented technology

A device and method for treating bodily conduits involves the application of energy to the smooth muscle tissue of the conduit walls to reduce the bulk of smooth muscle tissue and mucus glands. The irradiation treatment of the smooth muscle tissue causes a reduction in the amount of smooth muscle tissue over time which increases the inner diameter of the body conduit for improved fluid flow and prevents smooth muscle spasms. The treatment is particularly useful in the lungs for treatment of asthma to prevent bronchospasms, increase the airway diameter for improved air exchange, and reduce mucus secretions in the lungs.

A method of promoting the healing of a lesion in a smooth muscle, comprising selecting a smooth muscle portion having a lesion and applying a non-excitatory electrical field to the portion, which field reduces the mechanical activity of the portion.

A device and method for treating bodily conduits involves the application of energy to the smooth muscle tissue of the conduit walls to reduce the bulk of smooth muscle tissue and mucus glands. The irradiation treatment of the smooth muscle tissue causes a reduction in the amount of smooth muscle tissue over time which increases the inner diameter of the body conduit for improved fluid flow and prevents smooth muscle spasms. The treatment is particularly useful in the lungs for treatment of asthma to prevent bronchospasms, increase the airway diameter for improved air exchange, and reduce mucus secretions in the lungs.

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

A selective and extended sympathetic nerve block is achieved by administration of a botulinum toxin at and / or around a targeted sympathetic ganglion. The toxin induced sympathetic block finds use for the treatment of sympathetically maintained pain. The toxin induced sympathetic block is also used to treat cardiovascular conditions of sympathetically maintained vasoconstriction; and of undesirable smooth muscle spasm.

The invention discloses valerian preparation, which consists of valerian volatile oil, beta-cyclodextrin, valerian extract powder, starch for pharmaceutical, ethanol, magnesium stearate and talcum powder. A preparation method comprises the steps: A. adopting fresh valerian rhizomes, washing off mud and directly performing distillation through water-jacket pressurized steam after draining the valerian rhizomes to obtain the volatile oil and decoction dregs, B. drying the decoction dregs, placing the decoction dregs, using fresh medicinal materials to percolate the decoction dregs, filtering percolation liquid, recovering ethanol and then performing concentration to obtain the valerian extract powder, C. adding beta-cyclodextrin of the volatile oil into distilled water to be shaken up, then adding the valerian volatile oil to perform lapping and inclusion, using petroleum ether to wash off volatile oil which is not included and performing drying to obtain beta-cyclodextrin inclusion powder of the valerian volatile oil, and D. mixing the beta-cyclodextrin inclusion powder of the valerian volatile oil and the valerian extract powder to be filled into capsules. The valerian preparation is safe, effective, controllable and stable, has remarkable effects of resolving tetany, relieving pain and tranquilizing and soothing the nerves on digestive tract smooth muscles and can be used for treating smooth muscle spasmodic pain.

The invention relates to an externally applied traditional Chinese medicine composition for treating dysmenorrhea, as well as a preparation method and an application thereof. The externally applied traditional Chinese medicine composition comprises the following active pharmaceutical ingredients in parts by weight: 5-10 parts of nutgrass galingale rhizome, 5-10 parts of argy wormwood leaf, 3-5 parts of Chinese angelica, 3-5 parts of dahurian angelica root, 1-4 parts of officinal magnolia bark, 3-5 parts of motherwort herb, 0.5-2 parts of Chinese eaglewood and 3-6 parts of turmeric. The optimized scheme is as follows: one or more of 1-4 parts of white paeony root, 3-5 parts of Szechuan lovage rhizome, 2-5 parts of rhizoma corydalis, 1-4 parts of tree peony bark, 0.1-0.6 part of manchurian wildginger, 0.05-0.2 part of saffron and 0.2-0.8 part of flos caryophyllata are added. The externally applied traditional Chinese medicine composition disclosed by the invention can improve the comprehensive effects for treating the dysmenorrhea and simultaneously play the roles in inhibiting the contraction of uterine smooth muscle, strongly reliving the spasm of the uterine smooth muscle, alleviating pain, inhibiting swelling, promoting blood circulation, removing blood stasis, dilating blood capillaries and the like. Simultaneously, the externally applied traditional Chinese medicine composition disclosed by the invention has smaller toxicity and side effects and can not cause allergic reactions. The invention further provides the preparation method of the medicament and the application thereof in preparation of externally applied medicaments for treating the dysmenorrhea.

The invention provides a pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases, containing 80 parts by weight of grenadine juice, 180 parts by weight of antioxidant and a pharmaceutically acceptable carrier, wherein the antioxidant is one or the composition of many of the raw materials or raw material extracts or raw material concentrates of rice hull,carrot, pumpkin, cinnamon, broccoli, strawberry, blueberry, raspberry, green tea, sealwort, bitter caramon, tomato, pumpkin seed, resveratrol, vitamin E, vitamin C, grape pip, Brazil nut, Brazil large cherry, barley bran, rosemary, walnut leaf, tamarindus seed coat, cabbage, spinach, garlic and the like. The pharmaceutical composition provided by the invention has certain application values in treating or preventing cardiovascular and cerebrovascular diseases, treating or preventing hypertension, treating or preventing cardiovascular smooth muscle spasm and expanding the vascular smooth muscle.

A medicine containing the extract of pternoptalum root for treating stomach-ache, abdominalgia, peptic ulcer, smooth muscle spasm, etc is prepared from pternoptalum root through extracting in alcohol or water and preparing tablets or capsules.

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine navel paste for treating infantile diarrhea. The traditional Chinese medicine navel paste is prepared from the following medicinal raw materials: root of lobed kudzuvine, liquorice root, immature bitter orange, Chinese thorowax root, white peony root, coptis chinensis, medicated leaven, scorched hawthorn fruit, common ginger, medicinal evodia fruit, clove, cassia bark, costustoot, Indian buead, tuber fleeceflower stem and hirsute shiny bugleweed herb. According to the traditional Chinese medicine navel paste disclosed by the invention, a conventional treatment method for only treating symptoms of diarrhea without treating the root causes can be broken, various medicines are adopted, the digestive functions can be improved, the body fluid metabolism can be regulated, the yin and yang equilibrium can be corrected, the gastrointestinal smooth muscle spasm can be relieved, and thus the purposes of stopping diarrhea and relieving pain can be achieved; and the traditional Chinese medicine navel paste has the advantages of good curative effect, high cure rate, no toxic or side effects and convenience in use in the treatment of infantile diarrhea.

The ointment for treating frostbite and chilblain is prepared with anticholine drug powder and vaseline and through homogeneous mixing. Pharmacological test proves the effects of resisting peripheral M choline receptor, relieving acetylcholine caused smooth muscle spasm, improving circulation, etc of anticholine drug. Vaseline has the effects of preventing wind, preventing water and preventing frostbite. Therefore, the ointment with combined anticholine drug and vaseline has obvious frostbite and chilblain treating effect and no side effect when it is applied to the affected parts.

The invention discloses an astragali-date stomachic tea producing technology which is mainly characterized in that various traditional Chinese medicinal materials are mixed with half-fermentative Tie Guanyin oolong tea, a pure traditional Chinese medicinal formula is adopted and a biological activity fermentation technology are adopted, and a mucus gel which is generated after thearubigins, tea polyphenol, catechin ingredients and traditional Chinese medicinal materials are combined and fermented is utilized for overcoming the defect of harming of tea to stomachs. Due to the application of a 65 DEG C low temperature fermentation technology, biological enzyme in tea leaves is effectively prevented from being oxidized; besides, an enzyme fermentation greening technology is utilized, so that a certain freshness of the tea leaves is kept, active enzyme is prevented from being oxidized and therefore effective ingredients are prevented from being damaged; and by the combination of pharmacological actions of the traditional Chinese medicinal materials with Tie Guanyin, smooth muscle spasm can be relieved, stomachache is secured, and no toxic and side effects are caused; and the astragali-date stomachic tea can be drunk by common people, is available for invigorating and nourishing stomachs and does not lose flavor of tea leaves.

The invention belongs to the technical field of medicines, and relates to 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran derivatives and an application thereof. The 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran derivatives comprise stereoisomers and pharmaceutically acceptable salts of 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran, and the structural formula of the derivatives is shownin the description. The 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran derivatives and the pharmaceutically acceptable acid addition formed salts of 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran can be used together with existing medicines or individually, and are used for preparing medicines for treating blood vessel smooth muscle spasm diseases.

The invention discloses a healthcare food which can promote sleep quality and a preparation method thereof. The healthcare food adopts valerian as the main raw material and is prepared from the extractive of the valerian with ethanol by the method of reflux or diacolation. The extractive and accessory materials are then mixed evenly according to a proper proportion and made into grains which are cooled, sized and filled into capsule. The invention has the advantages that the invention has the healthcare functions such as pain relief, soothing the nerves, which has treatment effect on neurasthenic, insomnia, hysteria and epilepsy, etc. According to the modern medical theories, the invention can strengthen the inhibition action of pallium, reduce reflex excitation, relieve unstriated muscle convulsion and have the functions of tranquilizing, hypnosis, spasmolysis and pain relief. The invention has quick effect and high bioavailability.

The invention relates to bitter gourd drug toothpaste, which is characterized by containing the following components: 18wt% to 30wt% of bitter gourd, 0.1wt% to 0.25wt% of plant antibiotic, 35wt% to 48wt% of calcium hydrophosphate, 0.1wt% to 0.4wt% of sodium pyrophosphate, 10wt% to 18wt% of sorbierite, 1wt% to 2.5wt% of sodium carboxy methyl cellulose, 1.0wt% to 2.5wt% of laurinol sodium sulfate, 0.2wt% to 0.8wt% of spice, 0.2wt% to 0.5wt% of saccharin sodium, 0.5wt% to 2wt% of hairyvein agrimonia herb and bud, and purified water which is added to 100wt%. The toothpaste has the function of cleaning teeth of the ordinary toothpaste and has the efficacies of relieving the inflammation, sterilizing, stopping bleeding, treating ulcer, eliminating halitosis, preventing cold, bacillary dysentery and bronchitis, exciting the respiratory center, relieving smooth muscle spasm, treating Meniere's syndrome and the like.

The invention relates to a pharmaceutical composition for treating chronic bronchitis. The pharmaceutical composition for treating chronic bronchitis is prepared from the following components according to a shown weight part ratio range: 40-60 parts of aster, 40-60 parts of dandelion, 25-35 parts of phoenix-tail fern, 25-35 parts of radix tinosporae, 20-30 parts of bulbus fritillariae cirrhosae, 10-20 parts of dysosma versipellis, 10-20 parts of common andrographis herb, 10-20 parts of isatis root, 3-8 parts of herba lagotis, 3-8 parts of borneol and 3-8 parts of radix ophiopogonis. According to the pharmaceutical composition, all Chinese medicinal herbs are compatible, monarch and minister are cooperated, and assistant and guide are assisted, so that the pharmaceutical composition has the functions of carrying out desensitization and adjusting vegetative nerve imbalance, has the function of directly expanding airway smooth muscle, and is capable of relieving bronchus smooth muscle spasm to ensure that a subcutaneous nodule and epithelial cells of neutral cells are reduced and the cellular degeneration is lightened so that the virus toxicity is remarkably weakened. The pharmaceutical composition has a capacity of improving body defence, and lesion repair is promoted, the symptoms such as cough, phlegm, asthma and lung wheezing rale are remarkably relieved.

A radix astragali-jujube stomach-strengthening tea capsule production process mainly uses multiple mixed traditional Chinese medicinal materials and half-fermented Tie Guanyin oolong tea, adopts a pure traditional Chinese medicine formula and biological active fermentation technology, and produces mucus gel through combined fermentation of components of thearubigin, tea polyphenol, and catechin with traditional Chinese medicine; the production procedure adopts 60 DEG C low temperature fermentation technology, which effectively prevent bio-enzymes in tea from oxidation; enzyme fermentation green-making technology is adopted, which maintains certain freshness of the tea, prevents active enzyme oxidation, and thus prevents effective components from being destroyed; with the organic combination of the pharmacological effect of traditional Chinese medicine with the pharmacological effect of Tie Guanyin, the product can relax smooth muscle spasm, relieve stomachache, and has no toxic or side effect; the product can be used for drinking by common people, can strengthen the stomach and nourish the stomach, does not lose the tea flavor, is especially suitable for drinking by patients with gastric ulcer, duodenal ulcer, and atrophic gastritis, and has the functions of stomachache relief and rehabilitation.

The invention discloses a new process for preparing a traditional Chinese medicine belladonna liquid extract. The belladonna liquid extract is a domestic widely-used plant intermediate and clinically mainly used for gastric acid duodenal ulcer, angina of gastrointestinal tract, kidney and gallbladder and the like and has functions of removing smooth muscle spasm, restraining glandular secretion and the like. Original medicinal materials of the belladonna liquid extract are belladonna herb, and the belladonna herb is whole herb of Atropa belladonna L. A current main preparation method of the belladonna liquid extract is a percolation method, and the percolation method is long in consuming time, more in solvent consumption and insufficient in effective component enrichment. The invention discloses a process for preparing the belladonna liquid extract by ultrasonic dynamic multi-stage countercurrent extraction based on the conditions. According to the process, effective plant components are sufficiently extracted by the aid of ultrasonic cavitation effect, the dynamic multi-stage countercurrent extraction saves energy, and organic solvents are circularly used, so that the belladonna liquid extract is rapidly and effectively prepared. According to the process, an ultrasonic method is used in a dynamic multi-stage countercurrent extraction system for the first time.

The invention belongs to the field of medicine preparations, and particularly relates to a phloroglucinol injection solution and a preparation method thereof. The injection solution is used for acute spasmodic pain caused by digestive system and biliary tract dysfunctions. The phloroglucinol injection solution does not have a choline-resisting function, and does not affect cardiovascular functions while smooth muscle spasms are eliminated. The phloroglucinol injection solution disclosed by the invention has the advantages of good stability and the like, is unlikely to change colors in a long-term placement process, and is unlikely to be separated out.

The invention relates to extract of the steroid saponin produced from the yam or the yam with the guilder leaf which has the character of containing the 80%-90% the steroid saponin in the percentage by weight. The intravenous fluid produced from the extract of the steroid saponin can not only dilate the coronary, depress the myocardial oxygen consumption, melt the thrombus, improve the myocardial ischemia and the microcirculation, amend the function of the vas endothelial cell, increase the blood stream of the brain, prevent the ischemia brain cell injury, but also drop the blood pressure, the blood fat, the blood sugar; at the same time, it has the function of resisting inflammation, ease pain, codein, preventing asthma, dispelling the myospasm, improving the immunity and resisting the allergy. So it can cure the cerebrovascular, the rheumatism and the disease of the respiratory system. The invention has the good clinic extended value because of the low dosage of the active ingredient, the efficacy, the effecting quick and the high bioavailability.

A medicine for treating kidney calculi in the invention contains the following raw materials of: by weight, 6-8 parts of Rhamnella gilgitica Mansf. Melch., 8-10 parts of changuienia amoena chien, 6-8 parts of Gymnema yunnanense Tsiang, 3-5 parts of evening primrose, 8-10 parts of common adenostema herb, 8-10 parts of Lysimachia congestiflora Hemsl, 2-4 parts of dry maidenhair fern herb, 3-5 partsof Chinese cassia tree, 6-8 parts of bighead atractylodes rhizome, 6-8 parts of Poria cocos, 3-5 parts of gentrin knotweed, 2-4 parts of desmodium, 4-6 parts of Lygodium japonicum, 2-4 parts of SemenAbutili, 3-5 parts of plantago, 4-6 parts of radix bupleuri, 6-8 parts of oriental waterplantain rhizome, 3-5 parts of rheum officinale, 4-6 parts of white peony root, 1-3 parts of Artemisia capillaries and 1-3 parts of curcuma tuber. The medicine provided by the invention has effects of invigorating kidney qi, increasing functioning of bladder, keeping urinary function normal, dissolving stone, expelling stone, reducing renal colic and ureteral smooth muscle spasm, promoting qi circulation and relieving pain, clearing heat and draining dampness, and draining calculus. The effect of rushing, dissolving and draining calculus can be reached. In addition, the medicine provided by the invention has advantages of good curative effect, little side-effect and low cost.

Immunomodulatory pharmaceutical composition, each pharmaceutical dosage unit contains interleukin-25u~1500u, interferon 15u~1000u, thymosin 0.5ug~25ug, transfer factor 0.00002u~0.0015u, hydrocortisone 30ug~150ug, and is made of poultry eggs As an attachment agent, the above drug is added into poultry eggs, stirred evenly, dried and crushed into powder, and packed into capsules. The pharmaceutical composition can induce and stimulate the immune response to achieve the purposes of curing, preventing and maintaining health. Due to the small dose of active ingredients, there is no adverse toxic or side effect. After treating abdominal smooth muscle spasm, allergic purpura, diabetes, and vertigo, the curative effect is satisfactory.

The invention belongs to the technical field of medicines and relates to a 6-[2-hydroxyl-3-(alkylamino)propoxy]benzofuran compound and an application thereof. The 6-[2-hydroxyl-3-(alkylamino)propoxy]benzofuran compound comprises a stereoisomer and pharmacologically applicable salt of the compound and has the general structural formula shown in the description, wherein R is shown in the claims andspecification. The 6-[2-hydroxyl-3-(alkylamino)propoxy]benzofuran compound and the pharmacologically applicable salt-additive salt of the compound can be mixed with an existing medicine for use or used alone to be applied to a medicine for treating spastic diseases of vascular smooth muscle.

The invention belongs to the technical field of medicines and relates to a 5-[2-hydroxy-3-(alkylamine) propoxy] benzofuran compound and the application thereof. The 5-[2-hydroxy-3-(alkylamine) propoxy] benzofuran compound comprises a stereisomer of the compound and pharmaceutically applicable salt; the general molecular formula of the compound is shown as follows: wherein R is described as the claims and the specification. The 5-[2-hydroxy-3-(alkylamine) propoxy] benzofuran compound and the pharmaceutically applicable acid addition salt of the compound can be combined with the existing drug for use or can be used alone, and are used for preparing a drug for treating a vascular smooth muscle spastic disease.

The present invention discloses a traditional Chinese medicine for the assistant treatment of children bronchial pneumonia and bronchitis and the application method of the medicine, the main ingredients of which are: centipede, earthworm, bombyx batryticatus and licorice. The prescription composition combines the traditional Chinese medicine and western medicine with the mutual complementarity, the usage of the antibiotics and antiviral drugs have definite, obvious effects, so the invention has good effect; the traditional Chinese medicine for preparation can dispel the sputum, relieve the cough and relieve the spasm of the bronchial smooth muscle. The centipede in the traditional Chinese medicine has the functions of stopping spasm, extinguishing wind and detoxification, the bombyx batryticatus has the functions of extinguishing wind, relieving spasm, reducing phlegm and resolving masses, and the earthworm has the functions of relieving spasm, relieving asthma, anti-allergic and diuretic. The licorice has the functions of clearing fever, detoxification, relieving the acute symptoms and moistening lung, the a plurality of drugs are used for the treatment of the pneumonia cough, respiratory asthma and other symptoms of bronchial smooth muscle spasm.

The invention discloses a traditional Chinese medicine composition for treating chronic cardiac insufficiency, which is prepared by matching of the traditional Chinese medicines as follows: radix pseudostellariae, radix ophiopogonis, schisandra chinensis, astragalus membranaceus, the root of fangji, pepperweed seed, fructus trichosanthis, monkshood, poria cocos, pseudo-ginseng, bighead atractylodes rhizome, root of common peony, the root of red-rooted salvia, cortex acanthopanacis, Chinese-date, borneol, perillaseed, almond, pinellia ternate, caulis bambusae in taeniam and honey-fried licorice root. Aiming to the pathogenesis of heart failure: depletion of spleen and kidney, insufficient heart yang, blocking of blood vessel, damage of vital energy and blood, evil hydrops and pneuma rushing upwards to the chest, water and pneuma reversing upward and blocking of lung, the traditional Chinese medicine composition, disclosed by the invention, has the treatment rules of benefiting vitality and warming yang, purging the lung of pathogenic fire and promoting diuresis, promoting coronary circulation, improving blood supply of coronary artery, reducing blood pressure, purging the lung of pathogenic fire and regulating qi by alleviation of mental depression, clearing heat and eliminating phlegm, promoting diuresis and alleviating edema, enhancing systole, decreasing heart rate, reducing peripheral resistance, increasing cardiac output, improving microcirculation, relieving smooth muscle spasm and reducing blood platelet gathering rate.

The invention discloses novel pharmaceutical application of sodium aescinate and in particular discloses application of sodium aescinate in preparation of spasmolysis medicines for treating gastrointestinal smooth muscle spasm. The sodium aescinate has an obvious tension reduction effect on gastric tissue spasm caused by acetyl choline and can be used for treatment of diseases caused by gastrointestinal smooth muscle spasm such as acute gastroenteritis, colonitis, peptic ulcer, acute intestinal obstruction and the like. The clinical tests prove that the sodium aescinate has an obvious effect of treating gastric and intestinal colic caused by smooth muscle spasm, the total effective rate reaches 96.7%, and compared with atropine, the sodium aescinate does not have any obvious curative effect difference while is small in side effects.

The belladonna dripping pill as one anticholine medicine consists of belladonna extractum as medicine component 3-40 wt% and polyglycol as supplementary material 60-97 wt%. The preparation process of the belladonna dripping pill includes: mixing belladonna extractum and hot molten polyglycol; dropping the mixed liquid into paraffin as cooling agent in a dripping pill machine; sucking cooling agent with cloth; and selecting pills. The belladonna dripping pill has effectively dispersed belladonna extractum, raised dissolving degree, and the functions of resisting choline, relaxing the spasm of smooth muscle and inhibiting gland secretion. It is used in treating gastroduodenal ulcer, gastrointestinal angina and other gastrointestinal diseases, and has high curative effect and high stability.