3 results about "Smooth muscle spasm" patented technology

The invention provides a composition for preventing or treating acidic urinary stone of pets and application of the composition. The composition comprises citrate, N-acetylglucosamine, a corn stigma extract and a lysimachia christinae hance extract. The citrate can compete with oxalate ions and is preferentially combined with calcium ions to form a soluble calcium citrate compound, so that formation and growth of calcium oxalate crystals are inhibited, and kidney metabolic acidosis caused by improper acidification of urine is prevented. N-acetylglucosamine can repair a glycosaminoglycan layer of a bladder mucosa, reduce crystal adhesion and urethra stimulation, inhibit bacteria from adhering to the urethra, and reduce calculus and infection risks; the corn stigma extract is used for diluting the oxalic acid concentration of urine by increasing the urine volume of pets; the active ingredients of the lysimachia christinae hance extract can relieve urinary tract inflammation and smooth muscle spasm and relieve pain. The composition provided by the invention can effectively reduce formation of acidic urinary stones of pets, prevent bacterial adhesion and recurrent cystitis, and improve urinary system health of pets.

Providing a controlled-release formulation containing dorotaberine or its salts, or an active substance with a similar tendency to degrade through oxidation / hydrolysis. [Solution] The present invention provides a controlled-release formulation containing dorotaberine or a salt thereof, or an active substance with a similar tendency to degrade through oxidation / hydrolysis. The present invention provides a once- or twice-daily controlled-release formulation of dorotaberine or a salt thereof that avoids fluctuations in plasma levels, reduces pill burden and side effects through a simplified dosing schedule, and consequently improves patient compliance. The present invention also provides a method for preparing a controlled-release formulation of dorotaberine or a salt thereof. The present invention further provides a controlled-release formulation of dorotaberine or a salt thereof for the treatment of at least one symptom of gastrointestinal, biliary, urinary, and gynecological disorders characterized by a spastic state of smooth muscle in a subject.

The application belongs to the field of traditional Chinese medicines, and relates to a new application of Shouhui Tongbian capsules, in particular to an application of the Shouhui Tongbian capsules in a medicine for treating ureteral reflux. It is proved by a pharmacodynamic test that the traditional Chinese medicine composition can enhance the tension and activity of ureter and ileum smooth muscles, has a very important role in relieving ureter smooth muscle spasm and expanding ureter lumen, is beneficial to the transportation of urine, has a significant anti-ureteral reflux effect, is high in safety, and has a broad application prospect and positive clinical significance.