Sucralfate preparation

An aluminum preparation, sucralfate technology, applied in the directions of pill delivery, sugar-coated pills, medical preparations with inactive ingredients, etc., can solve the problems of short retention time of sucralfate, large toxic and side effects, poor treatment effect, etc. Fast gastrointestinal mucosa, reduce toxic side effects, improve the effect of treatment

Inactive Publication Date: 2019-03-08
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Abstract
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Problems solved by technology

[0005] The purpose of the present invention is to provide a sucralfate preparation to solve the problems of short retention time of sucralfate in the stomach, poor therapeutic effect and large toxic and side effects

Method used

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Embodiment Construction

[0027] The following is further described in detail through specific implementation methods:

[0028] The formula of the sucralfate preparation in embodiment 1-3 and comparative example 1-6 is as shown in table 1:

[0029] The raw material formula of table 1 sucralfate preparation

[0030]

[0031]

[0032] The preparation method of the sucralfate preparation in above-mentioned embodiment 1-3 and comparative example 1-6 comprises the steps:

[0033] (1) Pretreatment of traditional Chinese medicine components: Weigh rhubarb, sea octopus, chicken vine, panax notoginseng and Schisandra chinensis according to the formula ratio, mix them and grind them into fine powder, add 5-10 times the amount of 75% absolute ethanol for decoction Prepare the extract, dry the extract (drying temperature is controlled between 50-60°C), pulverize and sieve to obtain the Chinese medicine component powder;

[0034] (2) Preparation of micropills by centrifugal granulator: sieve sucralfate, tin...

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Abstract

The invention belongs to the technical field of pharmaceutic preparations, and particularly discloses a sucralfate preparation, which is prepared from the following materials in parts by weight: 30 to40 parts of sucralfate, 8 to 10 parts of tinidazole, 20 to 30 parts of an adhesive excipient, 15 to 25 parts of chondroitin sulfate, 1 to 3 parts of an acidic excipient, 30 to 40 parts of traditionalChinese medicine component, 5 to 8 parts of honey, 10 to 15 parts of a binder and 2 to 6 parts of a disintegrating agent. The sucralfate preparation is a tablet with the sucralfate, the tinidazole, the traditional Chinese medicine component, the adhesive excipient, the chondroitin sulfate, the acidic excipient and the like as main ingredients, wherein the sucralfate and the tinidazole are main drugs, which have a selective adhesive effect on gastric ulcers and enable the drug to target gastric ulcer sites; the adhesive excipient, the chondroitin sulfate and the acidic excipient can increase the viscosity of the drug, prolonging the retention time of the drug in the stomach; and the traditional Chinese medicine can relieve the side effect of the sucralfate and enhance the immunity of the body. The invention can reduce the frequency and dosage of administration, increase the therapeutic effect and reduce the toxic and side effects of the drug.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and specifically discloses a sucralfate preparation. Background technique [0002] Gastric ulcer is a common digestive tract disease, which is mainly formed due to the digestion of the mucous membrane by gastric acid and pepsin. Sucralfate is a commonly used drug for the treatment of gastric ulcer. It is an aluminum sucrose salt containing 8 sulfate groups. It is insoluble in water and most organic solvents, and only soluble in acid or lye. [0003] Under gastric acid conditions, sucralfate can dissociate into aluminum ions and octathio sucrose, aluminum ions can promote the secretion of bicarbonate, neutralize gastric acid, and adjust the pH of the mucosa; octasulfose can aggregate to form negatively charged, high-density, The viscous colloid can combine with the positively charged protein exuded from the injured mucosa to form a protective film on the surface of the gastric ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/74A61K31/7024A61K9/36A61K47/36A61K47/46A61K47/12A61K47/32A61K47/38A61P1/04A61K31/4164A61K35/618A61K35/644
CPCA61K9/2013A61K9/2027A61K9/205A61K9/2068A61K9/2866A61K31/4164A61K31/7024A61K35/618A61K35/644A61K36/258A61K36/57A61K36/708A61K36/74A61K36/79A61K2236/333A61K2236/51A61P1/04A61K2300/00
Inventor 李艳朱照静林凤云
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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