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An electro-optic display comprises first and second substrates and a lamination adhesive layer and a layer of a solid electro-optic material disposed between the first and second substrates, the lamination adhesive layer having a volume resistivity, measured at 10° C., which does not change by a factor of more than about 3 after being held at 25° C. and 45 percent relative humidity for 1000 hours. The electro-optic material is preferably an encapsulated electrophoretic material. Other desirable characteristics of lamination adhesives for use in electro-optic displays are also described.

RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 ng / kg to 150 ng / kg. The delivered RNA can elicit an immune response in the large mammal

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

The present invention relates to a novel piperidine derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts thereof, in which A, E and G are defined in the specification; to a process for preparation of the compound of formula (1); to an intermediate which is used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

The invention relates to a phase-transition composite material which comprises: A) 30-65% of phase-transition materials which are low melting point paraffin with a melting point of 25-45 DEG C and / or dodecanol; B) 25-45% of carrier materials which are high density polyethylane and / or ethane-vinylacetate copolymer; C) 5-15% of inorganic fillers which are porous substances and are selected from one or two of expanded perlite and expandable graphite; D) 1-10% of heat-conduction reinforcing agents; and E) 1-10% of fire retardants. The composite material has an appropriate phase transition temperature which matches the building ambient temperature, has great phase transition latent heat, excellent heat-preservation and heat-insulation performance, is fireproof and flame-retardant, is easy to process, and has greatly reduced phase-transition material leakage. The invention also relates to a method for preparing the phase-transition composite material, which comprises the thermal insulation mortar of the phase-transition composite material and a method of heat preservation of a wall by using the mortar.

A multi-component curable composition which is reactive upon admixing of the components and which comprises:(i) an acrylic polymer having acetoacetoxy functionality; and(ii) an acetoacetoxy functional derivative of a low molecular weight polyol; and(iii) a crosslinking component comprising at least one imine functional compound having an average of at least two imine groups per molecule which are reactive with acetoacetoxy functionality.

A core-shell particle including a signal-generating substance therein, wherein the core-shell particle consists of (1) a core portion substantially made of a water-insoluble polymer compound; and (2) a shell portion substantially made of a water-soluble polymer compound having a reactive functional group, and covering a surface of the core portion in the manner of bristles of a brush; and the core portion and the shell portion are, as a whole, a block copolymer of a water-insoluble polymer and a water-soluble polymer, characterized in that the signal-generating substance is included in the core portion, is disclosed, and a process for producing the same is also disclosed.The core-shell particle including a signal-generating substance therein is useful as a labeling substance in which neither radioisotopes having handling restrictions nor unstable enzymes are required, a high sensitivity superior to fluorescent substances is achieved, and nonspecific absorption does not occur.

The present invention relates to a method for preparing microsphere and microspheres produced thereby. The method comprises: mixing a water-insoluble organic solvent with a dispersion solvent; mixing a polymer compound, a drug and a water-insoluble organic solvent to prepare a dispersed phase; mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent to prepare an emulsion; and adding a base or an acid to the prepared emulsion. With the method, it is possible to prepare a drug-containing polymeric microsphere cost-effectively and conveniently.

Lubricant compositions comprising certain mixtures of esters of pentaerythritol, di-pentaerythritol, tri-pentaerythritol and higher pentaerythritol oligomers are ideally suited for use with CO2 as refrigerant in heat transfer devices provided that at least 30% by weight of the esters are esters of pentaerythritol oligomers containing 4 or more pentaerythritol monomer units and wherein a majority of the alkylcarboxylate groups are straight chain C3-6 alkanoyl groups, such as n-pentanoyl. Said mixture of alkylcarboxylate esters are shown to not only have higher than expected viscosity and exceptional CO2 miscibility, but also possess excellent lubricity, film building properties and load bearing properties even as part of a lubricant / CO2 solution.

The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal from drug dependency. In the latter case, the noribogaine treatment should be supplemented with the administration of an opioid antagonist such as naloxone.

Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole):and improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.

The present invention relates to nucleic acid sequencing methods, kits and reagents, and more particularly to methods of sequencing nucleic acid which employ a nucleic acid processing enzyme and one or more nucleotide analogues that are capable of binding to the active site of the enzyme and to complementary bases in the nucleic acid molecule being sequenced, but which are non-incorporable or inhibitors of the nucleic acid processing enzyme. In further aspects, the present invention relates to conjugates which comprise a deoxyribonucleotide triphosphates (DNTPs) or an analogue thereof linked to an intercalating dye.

PCT No. PCT / KR98 / 00039 Sec. 371 Date Nov. 6, 1998 Sec. 102(e) Date Nov. 6, 1998 PCT Filed Mar. 2, 1998 PCT Pub. No. WO98 / 39279 PCT Pub. Date Sep. 11, 1998The present invention relates to a novel 1,3-diphenylpropane derivative having an inhibitory activity against tyrosinase represented by the following formula (I): in which +E,uns - -+EE represents double or single bond, R1 represents hydrogen or C1-C10 alkyl, R2 represents C1-C5 alkyl or C1-C5 alkoxyalkyl, or R1 and R2 together represent a 5 to 6 membered heterocycle which can be substituted by C1-C5 alkyl and which contains oxygen as the hetero atom, R3 represents hydrogen or C1-C7 alkyl, R4 represents hydrogen, hydroxy, or oxo, and R5 and R6 mindependently of one another represent hydrogen or C1-C5 alkyl.

The present invention provides a method of evaluating the angiogenic potential of a tumor, and for predicting the efficacy of anti-angiogenic therapies on an individualized basis. The method of the invention involves preparing an angiogenic signature for malignant cells in culture by assaying for the presence or level of one or more angiogenesis-related factors selected from VEGF / VPF, IL8 / CXCL8, TGF-β1, TGF-β2, TGF-β3, bFGF / FGF-2, EGF, PDGF-AA, PDGF-AA / BB, IP-10, and Flt-3 ligand. The angiogenic signature may be prepared from cultures maintained under normoxic and / or hypoxic environments. The invention may be used in conjunction with chemoresponse testing of anti-tumor agents, to predict or suggest a combination therapy for cancer patients.

A compressible, thermally conductive foam interface pad is adapted for emplacement between opposed heat transfer surfaces in an electronic device. One heat transfer surface can be part of a heat-generating component of the device, while the other heat transfer surface can be part of a heat sink or a circuit board. An assembly including the foam interface pad and the opposed electronic components is also provided.

The present invention relates to a process for preparing a porous graphite carbon with high crystallinity, which comprises the steps of: (a) hydrothermally treating sucrose (i.e. carbon precursor), transitional metal precursor and uniform-sized silica particles at the same time to prepare a polymer; and (b) carbonizing the polymer, which can provide a porous graphite carbon with remarkably improved crystallinity suitable for a catalyst support for a fuel cell.

The invention discloses a process for preparing ultra-pure coal by utilizing an anthracite physical-chemical method. The process comprises the steps of anthracite grinding, flotation test, NaOH addingfor calcination and HCl adding for acid leaching to obtain ultra-pure coal. According to the process for preparing the ultra-pure coal by utilizing the anthracite physical-chemical method, by physical flotation treatment and alkaline-acid chemical reaction treatment on anthracite with higher ash content, the ash content can be deeply reduced to be lower than 2% and ultra-pure coal can conveniently and quickly be prepared.

The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I), wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and X− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

The invention relates to a method for removing phorbol esters from Jatropha curcas seed oil by extraction. The method comprises drying Jatropha curcas seed oil meal obtained from pre-squeezing and leaching processes, grinding into powder, mixing with industrial methanol at a weight ratio of 3.5:1.1 at 30 DEG C for more than 20 min, filtering to separate oil meal and methanol phase, collecting the oil meal and heating to remove residual methanol in the oil meal to obtain detoxicated plant protein; and concentrating the separated methanol phase to obtain phorbol ester product. After removing phorbol esters by methanol extraction, the content of phorbol esters in the oil meal is reduced from 1.78% to 0.014%, so that the oil meal can be used in preparing feed proteins.

Disclosed is a cured multilayer sheet production method, comprising adjacently laminating a first uncured layer formed by a first curable resin and a second uncured layer formed by a second curable resin to form a laminated body, wherein the first curable resin contains a first monomer or partial polymer thereof, and an immiscible substance, the second curable resin contains a second monomer and polymer, the first monomer concentration in the first curable resin is higher than the polymerizable monomer concentration in the second curable resin, wherein in the laminating step, the immiscible substance is eccentrically distributed on or near an interface on the side opposite to the second uncured layer, and thereafter curing the layers, so that a cured multilayer sheet, wherein a substance different from a polymer cured layer is eccentrically located on the surface of the polymer cured layer, is produced at high productivity.

The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.

This invention relates to a portable tea set with observation window, which is comprised by upper cap, tealeaves vessel, teacup and lower cap, featuring in: said tealeaves vessel is equipped with a one-body molded U-shaped filter sieve and an observation window outside, so that you can observe how tea is prepared and U-shaped filter sieve can filter tealeaves and tea water automatically, besides, bottom of tealeaves vessel and internal screw thread of lower cap can interact with top of teacup and bottom of external screw thread, thus, whole tea set can be assembled as required, in addition, owing to its small capacity and combination of whole structure, such tea set is portable and convenient to prepare tea water; meanwhile, it can separate tealeaves from tea water, so that tealeaves shall not be soaked in high temperature water for long time, quality of tealeaves can be preserved accordingly.

The present invention refers to a process for the preparation of supported catalysts for the polymerization of olefins comprising at least a late transition metal complex, wherein the process comprises two steps. In the first step a catalytically active component comprising at least one late transition metal complex, optionally in the presence of one or more cocatalysts is mixed with a support; and in the second step the obtained mixture is treated at a reduced pressure under a flow of inert gas at a temperature equal to or below 40° C. to obtain a supported catalyst. The method is especially useful for the preparation of dual supported catalysts, useful in the gas-phase polymerization of olefins.

The present invention relates to the device for animal inspection and quarantine and the preparation method thereof. The present invention is especially applicable to the detection of the pathogen of bovine spongiform encephalopathy (BSE) (also known as “mad cow disease”). The present invention employs a piezoelectric chip, a microelectrode array and a common electrode fixed on the lower side surface and upper side surface of the piezoelectric chip, respectively, and a BSE PrP antibody array to constitute the piezoelectric biochip for the detection of the BSE pathogen. The BSE PrP antibodies are immobilized on the electrodes of the microelectrode array in a format corresponding uniquely to the electrodes of the microelectrode array by adsorbing, bonding, cross-linking, embedding or self-assembly process. The combination of the piezoelectric biochip and a detector constitutes the piezoelectric biochip detection system for the BSE pathogen. When the antibodies react with the corresponding PrPs immunochemically, the information about the PrPs can be detected at real time by measuring the resonant frequency, and the PrPs thus can be analyzed qualitatively and quantitatively. The present invention is applicable to the early, effective and rapid detection of the BSE pathogen.

A process for the remediation and conditioning of soil containing a contaminant. The process comprises (a) mixing the soil with solid material comprising a source of microbial nourishment, (b) inoculating the mixed soil with a diverse microbe population capable of digesting the contaminant, and (c) maintaining the moisture content of the inoculated soil at a level sufficient to support microbial growth. The process can include the additional steps of applying a suspension fertilizer to the mixed soil and / or applying an oxygen-releasing compound to the mixed soil. Step (b) can be repeated to sufficiently reduce the level of contamination.

A resist composition comprising as a quencher a nitrogen-containing organic compound bearing a nitrogen-containing heterocycle and having a molecular weight of at least 380 exhibits a high resolution and satisfactory mask coverage dependence and is useful in microfabrication using electron beam or deep-UV.

The present invention relates to material processing technology, and is melt foaming process for preparing foamed magnesium. Through heating magnesium base material to melt, adding thickener and foaming agent, pouring the melt into a foaming tank, standing to foam inside one thermostatic oven, cooling after foaming, and machining to form foamed magnesium product. The added thickener is metal calcium powder accounting for 2-8 wt% of the melt, and the added foaming agent is calcium carbonate powder accounting for 2-15 wt% of the melt. The present invention has convenient operation, easy control and low cost, can produce foamed magnesium product of different pore sizes, and is suitable for industrial production.