Colloidal bismuth pectin tablets and preparation method thereof

A technology of colloidal bismuth pectin and bismuth pectin tablets, which is applied in the fields of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problem of poor swelling and dispersion effects of drugs, large particle size of drug particles, Poor fluidity and other problems, to achieve comprehensive and targeted protection, small particle size, excellent flow performance

Inactive Publication Date: 2016-10-26
ZHENGZHOU SIBIAN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the purpose of the present invention is to provide a kind of colloidal pectin bismuth tablet and preparation method thereof for the deficiencies in the prior art. , poor mobility, poor treatment effect

Method used

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  • Colloidal bismuth pectin tablets and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0025] A colloidal bismuth pectin tablet, comprising the following raw materials in parts by weight: 20 parts of colloidal bismuth pectin as bismuth, 8 parts of sucralfate as aluminum, 60 parts of white dextrin, 11 parts of polyvinylpyridinone, low Substitute 2 parts of hydroxypropyl cellulose, 5 parts of pharmaceutical silicon dioxide and 0.2 parts of magnesium stearate.

[0026] Its preparation method comprises the following steps:

[0027] (1) Add colloidal bismuth pectin and bismuth pectin to distilled water at a temperature of 60°C, stir, and perform homogenization treatment in a high-pressure homogenizer at 40Mpa to obtain glue;

[0028] (2) Add sucralfate, white dextrin, 75% polyvinylpyridone, low-substituted hydroxypropyl cellulose, drug With silicon dioxide and 70% magnesium stearate by magnesium stearate gross weight portion, stir, carry out homogeneous treatment in high-pressure homogenizer under 40Mpa, obtain mixed mortar;

[0029] (3) Spray the mixed mortar obta...

Embodiment 2

[0032] A colloidal bismuth pectin tablet, comprising the following raw materials in parts by weight: 30 parts of colloidal bismuth pectin as bismuth, 2 parts of sucralfate as aluminum, 120 parts of β-cyclodextrin, and 7 parts of sodium carboxymethyl starch , 6 parts of polyethylene glycol, 1 part of medical silicon dioxide and 2.8 parts of palmitic alcohol.

[0033] Its preparation method comprises the following steps:

[0034] (1) Add colloidal bismuth pectin and bismuth pectin to distilled water at a temperature of 80°C, stir, and perform homogenization treatment in a high-pressure homogenizer at 60Mpa to obtain glue;

[0035] (2) Add sucralfate, β-cyclodextrin, 85% carboxymethyl starch sodium, polyethylene glycol, medicinal Silica and the palmitic alcohol of 62% by palmitic alcohol gross weight portion, stir, carry out homogeneous treatment in high-pressure homogenizer under 60Mpa, obtain mixed mucilage;

[0036] (3) Spray the mixed mortar obtained in step (2), granulate,...

Embodiment 3

[0039] A colloidal bismuth pectin tablet, comprising the following raw materials in parts by weight: 22 parts of colloidal bismuth pectin as bismuth, 7 parts of sucralfate as aluminum, 100 parts of lactose, 8 parts of polyvinylpyridone, polyethylene glycol 3 parts of alcohol, 5 parts of medical silicon dioxide and 0.8 part of magnesium stearate.

[0040] Its preparation method comprises the following steps:

[0041] (1) Add colloidal bismuth pectin and bismuth pectin to distilled water at a temperature of 65°C, stir, and perform homogenization treatment in a high-pressure homogenizer at 55Mpa to obtain glue;

[0042] (2) Add sucralfate, lactose, 78% polyvinylpyridone, polyethylene glycol, medicinal silicon dioxide and The magnesium stearate of 68% by magnesium stearate gross weight part, stirs, carries out homogeneous treatment in high-pressure homogenizer under 55Mpa, obtains mixed mortar;

[0043] (3) Spray the mixed mortar obtained in step (2), granulate, and dry to obtai...

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Abstract

The invention discloses colloidal bismuth pectin tablets and a preparation method thereof. The colloidal bismuth pectin tablets consist of the following raw materials in parts by weight: 20-30 parts of colloidal bismuth pectin in terms of the content of bismuth, 2-8 parts of sucralfate in terms of the content of aluminum, 60-120 parts of a filling agent, 7-11 parts of a disintegrating agent, 2-6 parts of a binding agent, 1-5 parts of medicinal silicon dioxide and 0.2-2.8 parts of a lubricating agent. The colloidal bismuth pectin tablets disclosed by the invention are reasonable in the prescription of raw materials; the prepared colloidal bismuth pectin tablets are uniform and complete in appearance, small in particle size of particles therein and good in expansion effect in a stomach, and in addition, the colloidal bismuth pectin tablets are excellent in flowing property and good in distribution performance; and a formed gel can cover all ulcer surfaces of a patient and can take an excellent effect on treating superficial gastritis and gastric ulcer.

Description

technical field [0001] The invention relates to a bismuth agent and a preparation method thereof, in particular to a colloidal pectin bismuth tablet and a preparation method thereof. Background technique [0002] Colloidal bismuth pectin is a colloidal bismuth preparation, which is a salt formed by biomacromolecule pectinic acid (D-polygalacturonic acid) and metal bismuth ions and potassium ions. It has strong colloidal properties in acidic media , can form a solid protective film on the gastric mucosa, enhance the barrier protection of the gastric mucosa, so it has a good therapeutic effect on peptic ulcer and chronic gastritis, and can be used to kill Helicobacter pylori, which is beneficial to improve digestion The healing rate of ulcers and the reduction of recurrence rate have good effects on peptic ulcer, relief of symptoms of chronic gastritis, pathological improvement of chronic gastritis, and negative conversion rate of Helicobacter pylori. It is used for gastric an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/732A61K9/20A61K47/04A61K47/12A61K47/10A61P1/04A61K31/7024
CPCA61K33/245A61K9/2009A61K9/2013A61K31/7024A61K2300/00
Inventor 闵玉涛
Owner ZHENGZHOU SIBIAN TECH CO LTD
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