Optical imaging contrast agents

An optical, optical dye technique, applied to sulfated and/or phosphorylated sugars or their physiologically acceptable salts, sulfated and/or phosphorylated sugars, sugars or their physiologically acceptable salts, sugar metal salt field

Inactive Publication Date: 2008-06-18
MALLINCKRODT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] While many imaging reagents and methods are available for imaging and analyzing the gastrointestinal tract, there remains a need for imaging reagents and methods that provide rapid, accurate assessment without discomfort to the patient

Method used

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  • Optical imaging contrast agents
  • Optical imaging contrast agents
  • Optical imaging contrast agents

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Embodiment Construction

[0011] According to the present invention, it has been found that certain sugar molecules known to selectively bind to ulcerated and / or inflamed sites of the gastrointestinal tract after introduction can be replaced by at least one optical molecule to generate an optical imaging agent which can specifically target Navigate and image inflamed or ulcerated sites of the gastrointestinal tract. As used herein, "optical molecule" refers to optical dyes, nanoparticles, and optical dyes encapsulated in physiologically acceptable particulate materials suitable for optical detection in the gastrointestinal tract. Although suitable optical dyes for chemically incorporating sulfated and / or phosphorylated sugars are primarily discussed herein, it should be understood that suitable physically incorporated sulfated and / or phosphorylated sugars may be used in accordance with the present invention and may be used in Nanoparticles, including quantum dots, or optical dyes encapsulated in a phys...

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Abstract

The present invention provides compositions and methods for the selective identification of damaged sites in the gastrointestinal tract. More particularly, the compositions comprise a phosphated and / or sulfated saccharide, such as sucralfate, containing one or more optical molecules.

Description

Background of the invention [0001] The present invention generally relates to compositions and methods for selectively identifying sites of disease or injury in the gastrointestinal tract. More particularly, the present invention relates to sulfated and / or phosphorylated sugars or physiologically acceptable salts thereof, more particularly to polysulfated and / or polyphosphorylated sugar metal salts, such as sucralfate, with at least An optical molecular marker or containing at least one optical molecule, and use of these optical molecule-containing sulfated and / or phosphorylated sugars for the identification of gastrointestinal ulcers. [0002] Diagnosis of gastric ulcers and lesions generally requires visualization of the stomach and GI tract. Specific issues with the companion diagnosis for ulcers and lesions include distinguishing inflamed or ulcerated areas of the gastrointestinal lining from non-ulcerated, healthy sites. Current diagnostic methods may not always identif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCB82Y10/00A61K49/0067A61K49/0052B82Y5/00
Inventor 穆萨纳达·P·佩里亚萨米布赖恩·D·多蒂
Owner MALLINCKRODT INC
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