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Ciprofloxacin effervescent tablet for control of silkworm bacterial disease

A technology of ciprofloxacin and effervescent tablets, which can be used in antibacterial drugs, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as spillage, pollution, poor solubility, etc.

Inactive Publication Date: 2014-12-24
严相顺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent ZL03158369.5 discloses a capsule of ciprofloxacin, which overcomes the disadvantage that the half-life of the aqueous solution of ciprofloxacin is only tens of hours
However, when this preparation is applied, it needs to disassemble the quantified capsules for dissolution, which will cause spillage during the process, poor dissolution performance, external stirring is required, and pollution will be introduced

Method used

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  • Ciprofloxacin effervescent tablet for control of silkworm bacterial disease
  • Ciprofloxacin effervescent tablet for control of silkworm bacterial disease
  • Ciprofloxacin effervescent tablet for control of silkworm bacterial disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) The ratio of raw and auxiliary materials used is:

[0023]

[0024]

[0025] The above raw materials are made into 1000 tablets, each tablet contains 300mg of ciprofloxacin.

[0026] Proceed as follows:

[0027] (a) Sifting: pass each raw and auxiliary material through a 100-mesh sieve for use.

[0028] (b) Premix: Divide ciprofloxacin hydrochloride and lactose into two halves, and mix with tartaric acid and sodium bicarbonate respectively.

[0029] (c) granulation: dissolving polyvinylpyrrolidone in absolute ethanol, adding 10% polyvinylpyrrolidone absolute ethanol solution to the two mixtures obtained in step b respectively for granulation, passing through a 50-mesh sieve, and drying at 60°C 4h to obtain acid source particles and alkali source particles.

[0030] (d) granulating and mixing: after passing the acid source particles and alkali source particles obtained in step c through a 40-mesh sieve, mixing is performed, and the mixing time is 10-30 minut...

Embodiment 2

[0033] (1) The ratio of raw and auxiliary materials used is:

[0034]

[0035] The above raw materials are made into 1000 tablets, each tablet contains 300mg of ciprofloxacin.

[0036] Proceed as follows:

[0037] (a) Sifting: pass each raw and auxiliary material through a 100-mesh sieve for use.

[0038] (b) Premix: Divide ciprofloxacin lactate and lactose into two halves and mix with tartaric acid and sodium bicarbonate respectively.

[0039] (c) granulation: dissolving polyvinylpyrrolidone in absolute ethanol, adding 10% polyvinylpyrrolidone absolute ethanol solution to the two mixtures obtained in step b respectively for granulation, passing through a 50-mesh sieve, and drying at 60°C 4h to obtain acid source particles and alkali source particles.

[0040] (d) granulating and mixing: after passing the acid source particles and alkali source particles obtained in step c through a 40-mesh sieve, mixing is performed, and the mixing time is 10-30 minutes.

[0041] (e) T...

Embodiment 3

[0043] (1) The ratio of raw and auxiliary materials used is:

[0044]

[0045] The above raw materials are made into 1000 tablets, each tablet contains 300mg of ciprofloxacin.

[0046] Proceed as follows:

[0047] (a) Sifting: pass each raw and auxiliary material through a 100-mesh sieve for use.

[0048] (b) Premix: Divide ciprofloxacin hydrochloride and lactose into two halves, and mix with tartaric acid and sodium bicarbonate respectively.

[0049] (c) granulation: dissolving polyvinylpyrrolidone in absolute ethanol, adding 10% polyvinylpyrrolidone absolute ethanol solution to the two mixtures obtained in step b respectively for granulation, passing through a 50-mesh sieve, and drying at 60°C 4h to obtain acid source particles and alkali source particles.

[0050] (d) granulating and mixing: after passing the acid source particles and alkali source particles obtained in step c through a 40-mesh sieve, mixing is performed, and the mixing time is 10-30 minutes.

[0051...

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Abstract

The invention discloses a ciprofloxacin effervescent tablet for control of a silkworm bacterial disease and a preparation method. The effervescent tablet is used for controlling the silkworm bacterial disease and comprises the following components: ciprofloxacin (comprising ciprofloxacin hydrochloride or ciprofloxacin lactate), an acid source disintegrating agent, an alkali source disintegrating agent and an adhesion agent. Meanwhile, the invention further discloses the preparation method of the effervescent tablet. The preparation method disclosed by the invention is simple in process and low in cost; the prepared effervescent tablet is accurate in dosage and convenient to use, and capable of being applied to the control of the silkworm diseases.

Description

technical field [0001] The invention discloses a ciprofloxacin effervescent tablet for preventing and treating bacterial diseases of silkworm and a preparation method, and relates to the field of agriculture. Background technique [0002] Sericulture production is a traditional sideline in my country and one of the important ways to increase farmers' income. Because silkworms have limited resistance to bacteria, they are easily infected with bacteria and cause death. Drugs need to be used for prevention and control in time. Ciprofloxacin is a synthetic third-generation quinolone with broad-spectrum antibacterial activity. In production practice, ciprofloxacin is sprayed on mulberry leaves after being dissolved in water, and after feeding silkworms, it can fight common diseases such as black breast septicemia, blue-headed septicemia, bleeding septicemia and so on. [0003] Chinese patent CN1383826A discloses an aqueous solution composed of ciprofloxacin and distilled water....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/496A61P31/04
Inventor 严相顺严相平
Owner 严相顺
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