2 results about "Nosiheptide" patented technology

Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise DSPE-peg2000 and nosiheptide in a molar ratio of 3:1. Compositions and methods which is related to making the PEGylated liposomes and using the PEGylated liposomes for preventing or treating bacterial infection are also provided.

The invention relates to the technical field of pharmaceutical preparations, in particular to a high-dispersity nosiheptide preparation and a preparation method thereof. The high-dispersity nosiheptide preparation is prepared from the following raw materials in parts by mass: 1 to 5 parts of nosiheptide, 1 to 3 parts of sodium alginate, 2 to 4 parts of solubilizer, 1 to 2 parts of carboxyl-terminated polyamidoamine, 1 to 2 parts of dispersant, 5 to 15 parts of absolute ethyl alcohol, 0.1 to 1 part of nonionic surfactant, 0.1 to 0.5 part of L-ascorbic acid, 0.1 to 0.5 part of sodium thiosulfate and 1 to 2 parts of compound stabilizer. According to the method, the solubility of nosiheptide is guaranteed, the risk of organic solvent residue is reduced, the safety standard of modern veterinary drugs is met, conventional production equipment can be adopted, raw materials are low in price and easy to obtain, industrial large-scale production can be achieved, and high economical efficiency and operability are achieved.