Nosiheptide-sulfuric acid colimycin premix and preparation and using method thereof

Abstract

The invention discloses a nosiheptide-colistin sulfate premixed agent which comprises 0.5-4 portions of nosiheptide, 1-10 portions of colistin, and the carriers of calcium carbonate, zeolite powder, corn flour, etc. for the rest in every 100 weight portions. The preparation method is as following. The raw materials are added in a mixing machine by the sequence of the carriers, the colistin sulfate, the nosiheptide and the carriers, and mixed evenly to make into powdery nosiheptide-colistin sulfate premixed agent. Or the nosiheptide and the carriers can be mixed fully firstly, then the colistin sulfate is dissolved in the water and sprinkled evenly on the mixture of the nosiheptide and the carriers. After being granulated, dried and screened, the mixture is made into the granular-typed nosiheptide-colistin sulfate premixed agent, the granularity of which is 30-60 mesh. The nosiheptide-colistin sulfate premixed agent of the invention is added in feedstuffs. The content range of the nosiheptide in every kilogram of overhead price feedstuff is 0.5-20mg, and the content range of the colistin sulfate in every kilogram of overhead price feedstuff is 2-40mg.

Description

technical field [0001] The invention belongs to the field of feed drug additives, and in particular relates to a premix containing nosiheptide and colistin sulfate and a preparation and use method thereof. Background technique [0002] Nosiheptide is a new type of non-absorbable feed antibiotic successfully developed by Japan in the late 1980s. It was approved by my country in 1998 as a national third-class new veterinary drug. Feed drug additives that are used for medium and long periods of time. Nosiheptide is a sulfur-containing polypeptide antibiotic with the molecular formula C 51 h 43 N 13 o 12 S 6 , the molecular weight is 1122.35. Nosiheptide has high activity against most Gram-positive bacteria, and is also very effective against a small number of Gram-negative bacteria, so it has a good growth-promoting effect on livestock, poultry and aquatic animals. As a feed additive, nosiheptide has the characteristics of special use for animals, good growth-promoting ef...

AI Technical Summary

Problems solved by technology

[0004] Nosiheptide has strong antibacterial activity against Gram-positive bacteria, effective against a small number of Gram-negative bacteria, but almost ineffective against major intestinal pathogens such as Escherichia coli and Salmonella

However, colistin sulfate has a narrow antibacterial spectrum and has strong antibacterial activity against Gram-negative bacteria, but is almost ineffective against Gram-positive bacteria.