The invention relates to a Chinese herb medicinal additive for preventing tilapia fatty liver disease. The Chinese herb medicinal additive is characterized by comprising the following components in part by weight: 8 to 10 parts of mung bean, 1 to 3 parts of liquoric root, 1 to 3 parts of gentian, 1 to 3 parts of raw gardenia, 1 to 3 parts of baical skullcap root, 1 to 3 parts of bupleurum, 2 to 5 parts of rehmannia root, 1 to 3 parts of plantain herb, 1 to 3 parts of virgate wormwood herb, 1 to 3 parts of indigowoad root, 1 to 3 parts of Mongolian dandelion herb, 2 to 5 parts of feverfew, 1 to 3 parts of turmeric root-tuber and 1 to 3 parts of oriental waterplantain rhizome. The Chinese herb medicinal additive has the advantages of capacities of obviously reducing liver weight/body weight and fat content of muscle and liver of the tilapia, reducing glutamic-oxalacetic transaminase activity, glutamic-pyruvic transaminase activity, total cholesterol content and triglycercide content in tilapia serum, protecting liver cells from the damage of factors such as nutritional factors, environmental factors and the like and effectively preventing nutritional fatty liver disease in the breeding process of the tilapia, convenient addition and use, capacity of being added in a commercial feed directly, synergistic effect of the components and other additive components in the commercial feed, improvement on the disease resistance of the tilapia, stable raw material source, low cost, simple production process and easy industrialized production.