Compound long-acting norfloxacin nicotinate suspension for livestock and preparation method thereof

A technology of norfloxacin nicotinate and suspension, which is applied to medical preparations containing active ingredients, liquid delivery, pharmaceutical formulations, etc. The effect of good drug efficacy, widening antibacterial range and improving product yield

Inactive Publication Date: 2012-04-11
JIANGXI XINGERCHENG ANIMALS PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its antibacterial range is narrow, the therapeutic range is small, and the half-life is short. Due to the resistance of bacteria, the therapeutic effect of single use is reduced or has no effect, thus causing secondary infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: ① Take 10% of the total amount of water for injection and add 1 g of sodium carboxymethyl cellulose, stir evenly and soak for 8 hours to make a colloidal liquid A;

[0022] ② Take 30% of the total amount of water for injection and add 0.2g of sodium bisulfite to completely dissolve, add 2g of citric acid to completely dissolve, add 1g of β-cyclodextrin to completely dissolve, add 1g of metronidazole, norfloxacin nicotinic acid Star 2g, stir to completely dissolve into B liquid;

[0023] ③ Take 10ml of propylene glycol and 15ml of dimethylformamide and heat to 60-80℃, add 1g of trimethoprim and 1g of colistin sulfate to completely dissolve into liquid C;

[0024] ④ Add liquid A to liquid C, stir quickly and evenly, then add liquid B slowly, stir while adding, add Tween 0.1ml after suspension appears;

[0025] ⑤ Add water for injection to make up to 100ml, adjust the pH value to 5.0-8.0 with 1.5g sodium hydroxide, and grind for 20 minutes with a colloid mil...

Embodiment 2

[0026] Embodiment 2: ① Take 10% of the total amount of water for injection and add 2 g of sodium alginate, stir evenly and soak for 8 hours to make it into a colloidal liquid A;

[0027] ② Take 30% of the total amount of water for injection and add 0.2g of sodium metabisulfite to dissolve completely, add 2g of lactic acid, add 1.5g of β-cyclodextrin to completely dissolve, add 2.2g of metronidazole, 5g of norfloxacin nicotinate, and stir Make it completely dissolve into liquid B;

[0028] ③ Take 10ml of polyethylene glycol and 10ml of dimethylformamide and heat to 60-80℃, add 1.5g of trimethoprim and 1.5g of colistin sulfate to completely dissolve into liquid C;

[0029] ④ Add liquid A to liquid C, stir quickly and evenly, then slowly add liquid B, stir while adding, add Tween 0.2ml after suspension appears;

[0030] ⑤ Add water for injection to make up to 100ml, adjust the pH value to 5.0-8.0 with 5ml of ethanolamine, and grind for 30 minutes with a colloid mill. Asepticall...

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PUM

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Abstract

The invention relates to a compound long-acting norfloxacin nicotinate suspension for livestock and a preparation method thereof. The compound long-acting norfloxacin nicotinate suspension is characterized in that: 1000 mL of compound long-acting norfloxacin nicotinate suspension comprises 20-50 g of norfloxacin nicotinate, 10-60 g of diaveridine, 10-50 g of metronidazole, 10-50 g of colistin sulfate, 5-30 g of beta-cyclodextrin, 100-300 g of compound organic solvent, 1-5 g of surfactant, 10-40 g of acid-base regulating agent, 1-10 g of suspending aid, 1-10 g of antioxidant and the balance of water for injection. The compound long-acting norfloxacin nicotinate suspension has the advantages that: (1) the product has stable quality; (2) the product has good efficacy and long action time; (3) the product can be industrially produced in large scale and has low cost; and (4) synergistic agents, such as diaveridine, metronidazole and acrasin sulfate, are introduced to the product, a conventional dosage form is changed, and the suspension can well achieve long-acting controlled release, therefore, the efficacy of the product reaches or exceeds that of a similar product namely norfloxacin nicotinate injection.

Description

technical field [0001] The invention relates to a veterinary compound long-acting nicotinic acid norfloxacin suspension and a preparation method thereof. Background technique [0002] Piglet yellow, pullorum. Piglet yellow scour is caused by early-onset Escherichia coli, and piglet pullorum is caused by late-onset Escherichia coli. Acute porcine intestinal infectious disease caused by pathogenic Escherichia coli producing toxin in the intestinal tract. Piglets are yellow scours 3-10 days after birth, while those born more than 10 days are called pullorum, which can be judged by observing the color of feces. Both are acute infectious diseases of newborn piglets caused by pathogenic E. coli. If it is not treated in time, it will easily lead to the death of piglets and bring huge economic losses to pig farms and farmers. [0003] At present, there are monomer and compound drugs for the treatment of piglet yellow and pullorum on the market. Its antibacterial range is narrow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/10A61K47/40A61P31/04A61K31/4164A61K31/496A61K31/505
Inventor 倪荣炎于慧慧朱斌
Owner JIANGXI XINGERCHENG ANIMALS PHARMA
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