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Compound injection for treating animal respiratory tracts and preparation method thereof

A technology for animal respiratory tract and injection, which is applied in the field of compound injection and its preparation, can solve the problems of reduced therapeutic effect, narrow antibacterial range, and small therapeutic range, and achieve good drug efficacy, stable product quality, and improved product yield.

Inactive Publication Date: 2013-01-09
DAQING MUYUAN ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its antibacterial range is narrow, the therapeutic range is small, and the half-life is short. Due to the resistance of bacteria, the therapeutic effect of single use is reduced or has no effect, thus causing secondary infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: ① Take 30% of the total amount of water for injection, add 5% flunixin meglumine, 1% ribavirin, and 10% PVP-K30 and stir to completely dissolve into a solution;

[0021] ②Heat 10% propylene glycol and 20% dimethylformamide to 70 degrees Celsius, add 5% doxycycline hydrochloride and 5% tylosin tartrate and stir to completely dissolve into a solution;

[0022] ③ Add the solution obtained in step 2 to the solution obtained in step 1, add Tween-80 0.2%, add 0.2% anhydrous sodium sulfite pre-dissolved in water and stir evenly;

[0023] ④ Add water for injection to make the volume to 1000ml, measure the pH value of 9.0~11.0, adjust it with hydrochloric acid if it is high, and adjust it with sodium hydroxide if it is low. Aseptically subpackaged and sterilized, ready to use.

Embodiment 2

[0024] Embodiment 2: ① Take 30% of the total amount of water for injection, add 10% of flunixin meglumine, 2% of ribavirin, and 20% of PVP-K30 and stir to completely dissolve into a solution;

[0025] ②Heat 15% propylene glycol and 25% dimethylformamide to 70 degrees Celsius, add 10% doxycycline hydrochloride and 5% tylosin tartrate and stir to completely dissolve into a solution;

[0026] ③Add the solution obtained in step 2 to the solution obtained in step 1, add Tween-80 0.2%, add 0.2% sodium thiosulfate pre-dissolved in water and stir evenly;

[0027] ④ Add water for injection to make the volume to 1000ml, measure the pH value of 9.0~11.0, adjust it with hydrochloric acid if it is high, and adjust it with sodium hydroxide if it is low. Aseptically subpackaged and sterilized, ready to use.

Embodiment 3

[0028] Embodiment 3: ① Take 30% of the total amount of water for injection, add 10% of flunixin meglumine, 2% of ribavirin, and 20% of PVP-K30 and stir to completely dissolve into a solution;

[0029] ②Heat 20% propylene glycol and 25% dimethylformamide to 70 degrees Celsius, add 5% doxycycline hydrochloride and 10% tylosin tartrate and stir to completely dissolve into a solution;

[0030] ③ Add the solution obtained in step 2 to solution 1 obtained in step 1, add poloxamer 1% and stir to completely dissolve, add 0.2% sodium thiosulfate pre-dissolved in water and stir evenly;

[0031] ④ Add water for injection to make the volume to 1000ml, measure the pH value of 9.0~11.0, adjust it with hydrochloric acid if it is high, and adjust it with sodium hydroxide if it is low. Aseptically subpackaged and sterilized, ready to use.

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PUM

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Abstract

A compound injection for treating animal respiratory tracts is characterized in that every 1000mL of the compound injection for treating animal respiratory tracts contains 5 to 20g of flunixin meglumine, 5 to 10g of doxycycline hydrochloride, 5 to 10g of tylosin tartrate, 1 to 5g of ribavirin, 10 to 20g of PVP-K 30, 250-600g of compound organic solvent, 0.2 to 5 g of surfactant, 10 to 40g of acid alkaline blender, 1 to 10g of antioxidant, and the balance of water for injection. The compound injection has the following advantages: (1) the product quality is stable; (2) the product efficacy is good and the action time is long; (3) the product can be conducted for industrialized mass production and the cost is low; and (4) doxycycline hydrochloride and tylosin tartrate in the products are synergistic each other, and flunixin meglumine as an antipyretic, analgesic and anti-inflammatory drug is added for relieving exterior syndrome, so that the efficacy of the product reaches or exceeds the similar product flunixin meglumine injection.

Description

technical field [0001] The invention relates to a compound injection and a preparation method thereof, in particular to a compound injection for treating livestock respiratory tract and a preparation method thereof. Background technique [0002] Porcine respiratory syndrome (PRDC), commonly known as porcine respiratory disease, is a multifactorial disease caused by one or more interactions among bacteria, viruses, mycoplasma, environment, stress and other factors. The main pathogens are: PRRS, circovirus (PCV-2), pseudorabies (PRV), swine influenza virus (SIV), mycoplasma (MH), atrophic rhinitis, pleuropneumonia, streptococcus, salmonella, etc. . [0003] The most threatening disease is asthma. Mycoplasma will destroy the bronchial cilia system, inhibit the movement of cilia, cause the cilia to shrink or even fall off, and lose the function of shaking mucus, or the cilia fall off without mucus secretion, so that many pathogens can take root here or Or make it through...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K9/08A61P11/00A61P31/04A61P31/12A61K31/7048A61K31/65A61K31/44
CPCY02A40/70
Inventor 李之财朱斌徐亚洲王立峰
Owner DAQING MUYUAN ANIMAL PHARMA
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