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Veterinary long-acting compound doxycycline hydrochloride injection and preparation method thereof

A technology for doxycycline hydrochloride and doxycycline, which is applied in the directions of tetracycline active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems of no imported products, no data reports, and unstable performance. , to achieve the effect of low production cost, broadened antibacterial spectrum and stable production process

Active Publication Date: 2015-09-16
广东正大康生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Market surveys show that domestic unilateral doxycycline hydrochloride injections are currently on the market, but the performance of the products produced by most manufacturers is unstable, prone to discoloration, precipitation, and failure. There is still no product on the market for the injection, and there is no relevant data report; no related imported product or related report has been found, so the compound doxycycline hydrochloride injection will have a very broad market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Take 100ml of water, add 25g of magnesium chloride to dissolve, then add 1g of sodium bisulfite to dissolve, then add 50g of doxycycline hydrochloride, stir evenly, dissolve, heat up to 60°C, and chelate for 2 hours. spare. Separately take 200 g of α-pyrrolidone and 500 g of propylene glycol to form a composite organic solvent, heat to 80° C., add 50 g of sulfamethoxine to dissolve. Mix the above two liquids, adjust the pH value to 5.0 with about 25 g of ethanolamine, add water to the full amount, filter, sub-package, sterilize, and pack to get ready.

Embodiment 2

[0013] Example 2: Take 100ml of water, add 60g of magnesium sulfate to dissolve, then add 2g of sodium formaldehyde sulfoxylate to dissolve, then add 100g of doxycycline hydrochloride, stir evenly to dissolve, heat up to 50°C, and chelate Together for 3 hours, spare. Separately take 200 g of α-pyrrolidone and 200 g of propylene glycol to form a composite organic solvent, heat to 60° C., add 100 g of sulfamethoxine to dissolve. Mix the above two liquids, adjust the pH value to 6.0 with about 50 g of ethanolamine, add water to the full amount, filter, sub-package, sterilize, and pack to get ready.

Embodiment 3

[0014] Example 3: Take 100ml of water, add 80g of magnesium oxide to suspend, then add 4g of sodium bisulfite to dissolve, then add 200g of doxycycline hydrochloride, stir evenly to dissolve, heat up to 80°C, and chelate 3 hours, spare. Separately take 200 g of α-pyrrolidone and 250 g of propylene glycol to form a composite organic solvent, heat to 100° C., add 200 g of sulfamethoxine to dissolve. Mix the above two liquids, adjust the pH value to 7.0 with about 100 g of ethanolamine, add water to the full amount, filter, subpackage, sterilize, pack, and get ready.

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PUM

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Abstract

The invention provides a method for preparing a long-acting compound doxycycline hydrochloride injection for animals. The method comprises the following steps: adding a complexing agent into a proper amount of water to dissolve or suspending the complexing agent; adding an antioxidant to dissolve; adding doxycycline hydrochloride, and uniformly stirring; heating to a temperature of 60-80 DEG C, and chelating for 2-3 hours for later use; heating a compound organic solvent, heating to a temperature of 80-100 DEG C, adding sulfamonomethoxine to dissolve; mixing the two solutions, regulating the pH value to be 5.0-7.0 with ethanol amine, and adding water to full volume; and filtering, subpackaging, sterilizing and packaging to obtain the injection. The method has the advantages that (1) the preparation is high in chelation degree and stable in quality; (2) a sustained-release agent can assist solution and sustain action, the drug effect can last 72 hours after once administration in a normal dosage; (3) the antibacterial spectrum of the injection is widened, the antibacterial effect of the injection is strengthened, the clinical curative effect of the preparation is remarkably superior to that of a single doxycycline hydrochloride injection, the long-acting compound doxycycline hydrochloride injection can be widely applied to respiratory tract, genitourinary tract, gastrointestinal tract or mixed infection caused by various bacteria, mycoplasma, chlamydia, toxoplasm and the like; (4) the preparation production process is stable.

Description

technical field [0001] The invention relates to a veterinary long-acting compound doxycycline hydrochloride injection and a preparation method thereof. Background technique [0002] Doxycycline hydrochloride is the second-generation semi-synthetic antibiotic of the tetracycline class, an alternative product of oxytetracycline, and is one of the most widely used antibiotics for livestock and poultry and other animals. Doxycycline hydrochloride, as a basic drug for livestock and poultry health care, is usually added to feed or made into injection, which can be used for the prevention and group treatment of various diseases of animals when added to feed. Doxycycline hydrochloride injection is more used for the treatment of indications, and can also be used for animal health care. It is mainly used for respiratory tract, urogenital tract and gastrointestinal tract caused by various bacteria, mycoplasma and chlamydia in animals. Infect. Unilateral Doxycycline Hydrochloride Inje...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/65A61K9/08A61P31/04A61P31/00A61P33/02A61K31/635
Inventor 李龙瑞周奀忠张吉鹍罗灵陈金兴王新斌廖海兵杨志明邵智军郭春玉
Owner 广东正大康生物科技股份有限公司
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