Compound long-acting norfloxacin nicotinate suspension for livestock and preparation method thereof

Abstract

The invention relates to a compound long-acting norfloxacin nicotinate suspension for livestock and a preparation method thereof. The compound long-acting norfloxacin nicotinate suspension is characterized in that: 1000 mL of compound long-acting norfloxacin nicotinate suspension comprises 20-50 g of norfloxacin nicotinate, 10-60 g of diaveridine, 10-50 g of metronidazole, 10-50 g of colistin sulfate, 5-30 g of beta-cyclodextrin, 100-300 g of compound organic solvent, 1-5 g of surfactant, 10-40 g of acid-base regulating agent, 1-10 g of suspending aid, 1-10 g of antioxidant and the balance of water for injection. The compound long-acting norfloxacin nicotinate suspension has the advantages that: (1) the product has stable quality; (2) the product has good efficacy and long action time; (3) the product can be industrially produced in large scale and has low cost; and (4) synergistic agents, such as diaveridine, metronidazole and acrasin sulfate, are introduced to the product, a conventional dosage form is changed, and the suspension can well achieve long-acting controlled release, therefore, the efficacy of the product reaches or exceeds that of a similar product namely norfloxacin nicotinate injection.

Description

technical field [0001] The invention relates to a veterinary compound long-acting nicotinic acid norfloxacin suspension and a preparation method thereof. Background technique [0002] Piglet yellow, pullorum. Piglet yellow scour is caused by early-onset Escherichia coli, and piglet pullorum is caused by late-onset Escherichia coli. Acute porcine intestinal infectious disease caused by pathogenic Escherichia coli producing toxin in the intestinal tract. Piglets are yellow scours 3-10 days after birth, while those born more than 10 days are called pullorum, which can be judged by observing the color of feces. Both are acute infectious diseases of newborn piglets caused by pathogenic E. coli. If it is not treated in time, it will easily lead to the death of piglets and bring huge economic losses to pig farms and farmers. [0003] At present, there are monomer and compound drugs for the treatment of piglet yellow and pullorum on the market. Its antibacterial range is narrow,...

AI Technical Summary

Problems solved by technology

Its antibacterial range is narrow, the therapeutic range is small, and the half-life is short. Due to the resistance of bacteria, the therapeutic effect of single use is reduced or has no effect, thus causing secondary infection