Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof

A technology for piglet diarrhea and traditional Chinese and Western medicine, which is applied in the field of veterinary medicine, can solve the problems of insufficient control of diarrhea, untimely control of diarrhea symptoms, and large stress reaction of piglets, and achieves improved feed conversion rate, easy food intake and swallowing, and uniform distribution. Effect

Inactive Publication Date: 2015-08-26
XINYANG AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in recent years, piglet diarrhea, no matter what the cause is, has the characteristics of acute onset and rapid disease development. The diseased piglets are often dehydrated due to untimely control of diarrhea, and severe diarrhea leads to dehydration, and eventually collapses and dies.
The reason for this phenomenon, on the one hand, is that the control of diarrhea symptoms is not timely or the intensity of diarrhea control is not enough; no relationship
For diseases that occur in the gastrointestinal tract, it is more direct and effective to treat by oral administration; however, newborn piglets will not eat solid feed, or even swallow solid feed with too large particles; existing common solutions, pastes Although medicines, powders, and powders can be given by force-feeding, this way of administration is not only difficult, but also requires a lot of work, and the stress response to newborn piglets is also very large.

Method used

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  • Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof
  • Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof
  • Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Curative Effects of Different Drug Combinations on Piglet Pullorum

[0039] Materials: bacitracin zinc, colistin sulfate and gallnut (all commercially available).

[0040] Cases: 100 cases of pullorum in piglets with natural onset in a pig farm. The sick pork chops were white, off-white or yellow-white with foul-smelling loose stools; they were diagnosed as Escherichia coli infection by the laboratory.

[0041]Method: Orally disintegrating tablets were made according to the raw materials in Table 1, and test samples 1 to 4 were obtained, "—" means no addition. Under the same feeding conditions, the diseased pigs were randomly divided into test group 1, test group 2, test group 3, test group 4 and blank group; test group 1 to test group 4 used test product 1 to test product 4 respectively, and 1 tablet / kg·bw was directly fed into the mouth of piglets once a day for 3 consecutive days; the blank group was fed according to the daily feeding method without drug administra...

Embodiment 2

[0056] Study on the Curative Effect of Different Drug Combinations on Transmissible Gastroenteritis of Piglets

[0057] Materials: bacitracin zinc, colistin sulfate and gallnut (all commercially available).

[0058] Case: 100 cases of transmissible gastroenteritis in piglets with natural onset in a pig farm. Sick pigs often vomited after sucking breast milk, and soon developed severe diarrhea, yellow or gray watery loose stools, often mixed with undigested condensate Breast lumps, malodorous; laboratory diagnosis of infectious gastroenteritis.

[0059] Method: Orally disintegrating tablets were made according to the raw materials in Table 4, and test samples 1 to 4 were obtained, "—" means no addition. Under the same feeding conditions, the diseased pigs were randomly divided into test group 1, test group 2, test group 3, test group 4 and blank group; test group 1 to test group 4 used test product 1 to test product 4 respectively, and 1 tablet / kg·bw was directly fed into th...

Embodiment 3

[0069] (1) Investigation of the joint effect of different disintegrants

[0070] Materials: Mannitol, MCC, L-HPC, sucrose and SDS (all commercially available).

[0071] The orally disintegrating tablets were made according to the raw materials in Table 6, and the ratio schemes of different disintegrant combinations and the evaluation results of disintegration time were shown in Table 6.

[0072] Table 6 The ratio scheme of different disintegrant combinations and the evaluation results of disintegration time limit

[0073]

[0074]

[0075] It can be seen from Table 6 that the combined application of disintegrants mannitol, MCC, sucrose, L-HPC, and SDS has a synergistic effect; especially the application of SDS greatly improves the disintegration speed.

[0076] (2) Investigation of the combined effect of different flavoring agents

[0077] Materials: mannitol, MSG, potassium chloride, sucrose, sodium glycyrrhizinate and fresh milk essence (all commercially available). ...

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Abstract

The invention relates to the field of veterinary medicines and particularly relates to a Chinese and western medicine composition for treating piglet diarrhea and a preparation method thereof. The Chinese and western medicine composition for treating piglet diarrhea is mainly prepared from 10-50 parts by weight of gallnut, 1-9 parts of bacitracin zinc and 0.5-1.5 parts of colistin sulfate. The Chinese and western medicine composition is enhanced in synergetic effect of raw materials, has an efficient prevention and treatment effect on piglet diarrhea, is nearly free from toxic and side effects, and further is capable of promoting growth of livestock and poultry and improving the feed conversion ratio. The invention further provides a preparation method of fast buccal disintegrating micropowder. The method comprises the following steps: dissolving out active ingredients in the gallnut by virtue of a water decocting method and mixing the obtained liquid medicine with other ingredients so as to facilitate fusion among the active ingredients. The prepared medicine is uniform in active ingredient distribution; the preparation method is simple, energy consumption is saved and the prepared medicine is excellent in palatability and disintegration speed performances.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a Chinese and Western medicine composition for piglet diarrhea and a preparation method thereof. Background technique [0002] Piglet diarrhea has been a technical problem that has plagued pig farming for a long time. Especially in recent years, both the incidence and the mortality rate of piglet diarrhea have been increasing year by year. It is mainly caused by the following two reasons. On the one hand, the pathogen is complicated and there are no effective preventive measures; on the other hand, it is difficult to treat after the disease occurs. At present, the prevention and treatment of piglet diarrhea usually adopts symptomatic treatment, that is, prevents secondary infection and supplements electrolytes and water by injecting antibacterial drugs. However, in recent years, piglet diarrhea, no matter what the cause is, has the characteristics of acute onset and rapid deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/20A61P1/12A61K35/64A61K33/14A61K31/198
Inventor 何敏陈敏李建柱张敏李迎晓
Owner XINYANG AGRI & FORESTRY UNIV
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