20 results about "Diarrhea symptoms" patented technology

The invention belongs to the technical field of biological medicines, and particularly relates to application of UH15-38 in preparation of a medicine for preventing and treating PEDV-PoRVA co-infection. According to the invention, a PEDV and PoRVA co-infected piglet model is systematically established for the first time, a high-throughput transcriptomics means is combined, an enhancement mechanism of co-infection on host pathogenicity is deeply analyzed from an immune regulation level, and based on the mechanism, UH15-38 is found to be capable of effectively treating PEDV and PoRVA co-infected piglets. Experimental data show that the UH15-38 remarkably relieves clinical diarrhea symptoms caused by co-infection, reduces the copy number of PoRVA and PEDV viruses, effectively inhibits duplication of the viruses in intestinal tracts, remarkably reduces the expression levels of IL-1beta and p-MLKL in jejunum tissues, and reduces necrotic apoptosis and inflammatory response. The UH15-38 can provide a new application value for the treatment of the porcine viral diarrhea.

The application discloses a composition, which comprises hydrolyzed protein; the hydrolyzed protein comprises hydrolyzed whey protein and hydrolyzed casein protein, the weight ratio of the hydrolyzed whey protein and the hydrolyzed casein protein is (70-95):(5-30), the amino acid nitrogen content in the hydrolyzed protein is (1.0-3.0) g / 100 g, the proportion of protein hydrolysate with a relative molecular mass distribution <1000 in the hydrolyzed protein is 34-70%, the peptide content (calculated on a dry basis) in the hydrolyzed protein is not less than 33 g / 100 g, and the total free amino acid content in the hydrolyzed protein is not less than 1 g / 100 g. The composition can effectively treat diarrhea and is suitable for people with gastrointestinal dysfunction and severe patients with diarrhea symptoms.

The invention relates to the technical field of pet disease treatment, and discloses a microbial preparation for treating inflammatory bowel disease, which is prepared from the following raw materials in parts by weight: 3 to 5 parts of clostridium palustris microecological preparation, 30 to 35 parts of enzymolysis chicken liver powder, 10 to 15 parts of glutamine, 8 to 10 parts of fructo-oligosaccharide, and 1 to 3 parts of beta-1, 3, 4-trimethyl-1, 3-pentanediol monoisobutyrate. The composition is prepared from the following components in parts by weight: 10 to 15 parts of 1, 3-D-glucan, 39.5 to 40 parts of maltodextrin, 0.2 to 0.5 part of silicon dioxide and 0.5 to 1 part of magnesium stearate. According to the microbial preparation for treating the inflammatory bowel disease, diarrhea symptoms of tested pets can be relieved to different extents by preparing the microbial preparation, the intestinal functions of the pets can be directly improved to different extents compared with those before, and due to the fact that the absorption and metabolism functions of intestinal tracts on nutrient substances are improved, the intestinal tracts can be prevented from being damaged. Therefore, malnutrition of the tested pets caused by diseases is relieved for a long time, the weight of the tested pets is increased to different degrees, and the microbial preparation has a positive effect on the pets suffering from the chronic bowel diseases.

The invention discloses application of a pain and diarrhea prescription to regulation and control of a BLP + macrophage subgroup to treat IBS-D. The pain and diarrhea prescription contains a liver soothing component (6-10 parts of pericarpium citri reticulatae and 6-10 parts of radix saposhnikoviae) and a spleen tonifying component (10-15 parts of rhizoma atractylodis macrocephalae and 10-15 parts of radix paeoniae alba) or a combination of the liver soothing component and the spleen tonifying component according to the ratio of 1: (1-2). By promoting the expression of anti-inflammatory cytokines IL-10 and TGF-beta, inhibiting the expression of pro-inflammatory cytokines IL-6 and TNF-alpha, activating an AMPK signal channel, inhibiting an NF-kappa B signal channel and promoting the expression of colonic mucosal barrier indexes ZO1 and OCLN, a colonic mucosal barrier is repaired, and the symptoms of IBS-D abdominal pain and diarrhea are relieved. The invention also provides a pharmaceutical composition containing the key active component, and the dosage forms comprise an aqueous solution, a tablet and the like. The traditional Chinese medicine composition solves the problems of large toxic and side effects, poor compliance and unknown mechanism in the existing IBS-D treatment, is definite and safe in curative effect, and has important clinical value and scientific significance.

The invention relates to the technical field of probiotics, and discloses probiotic powder containing dietary fibers and a preparation method thereof, the probiotic powder comprises the following raw materials: lactobacillus rhamnosus, bifidobacterium bifidum, bifidobacterium lactis, a quercetin inclusion compound, fructo-oligosaccharide, erythritol and fruit powder; wherein the quercetin clathrate compound is prepared by taking chitosan and erucic acid as a shell and quercetin as an inner core; according to the present invention, the stability of the quercetin in the gastric juice can be improved by inclusion of the quercetin so as to provide the anti-diarrhea effect, the chitosan is the dietary fiber and can further relieve the diarrhea symptom, and the mutual cooperation of the components realizes the complementation reinforcement of the components, regulates the balance of the flora in the intestinal tract, and significantly improves the diarrhea treatment effect; therefore, the traditional Chinese medicine composition has a wide application prospect.

The invention discloses a Saccharomyces cerevisiae strain with an intestinal tract probiotic function, the Saccharomyces cerevisiae strain is named as GLMQ-1, the classification name is Saccharomyces cerevisiae, the preservation number is CGMCC NO.34261, the preservation date is April 18, 2025, and the preservation unit is China General Microbiological Culture Collection Center, No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing. The saccharomyces cerevisiae is separated from yak yoghurt in Qinghai province, has relatively strong acid and cholate tolerance, has good co-aggregation capability on escherichia coli, staphylococcus aureus and candida albicans, and can relieve antibiotic-induced diarrhea symptoms of mice and improve the tolerance on antibiotic-related diarrhea. The saccharomyces cerevisiae disclosed by the invention can be used for preparing anti-diarrhea medicines or microecologics, and has a very wide application prospect.

The application belongs to the technical field of biological medicine, and particularly relates to application of phosphatidylcholine in preparation of a medicine for preventing and treating porcine rotavirus infection. The application finds that phosphatidylcholine (PC) has significant antiviral activity in preventing and treating PoRVA infection. Experimental results show that PC can effectively inhibit PoRVA proliferation, reduce viral load, and then relieve diarrhea symptoms caused by PoRVA infection and reduce mortality. In addition, PC can also inhibit necrotic apoptosis induced by PoRVA infection, promote repair and maintenance of intestinal barrier integrity, reduce intestinal tissue damage, and reduce the risk of secondary infection. The above results show that PC has good therapeutic potential for PoRVA infection. At the same time, PC is safe in source, has good biocompatibility, and no obvious toxic side effects are observed within a reasonable dose range, and is suitable for prevention and / or treatment of PoRVA infection, and has good application prospect and popularization value.

The invention discloses an application of a phthalocyanine compound and a delivery system thereof in preparation of an anti-clostridium difficile toxin drug, and discovers that phthalocyanine can specifically target TFPI, CSPG4 and FZD1, 2, 7 receptor binding domains of clostridium difficile toxin B (TcdB), and effectively inhibits binding of toxin and host cells. In-vitro experiments prove that the phthalocyanine (Phthalocyanine, Pc) can be used for remarkably relieving the cytopathy induced by TcdB and has no cytotoxicity. In order to improve the curative effect, an extracellular vesicle (S-EV) from saccharomyces boulardii is creatively adopted to construct a drug loading system S-EV-Pc, and the pH responsive intestinal targeted delivery of the drug is realized. Animal experiments show that the preparation can significantly improve the survival rate of infected gerbil to 100%, significantly improve diarrhea symptoms, reduce intestinal TcdB load and relieve tissue pathological damage. The invention discloses the potential of phthalocyanine as a non-antibiotic small molecule drug in treatment of clostridium difficile infection (CDI) for the first time, and provides a brand new strategy and an experimental basis for developing a novel anti-CDI preparation.

The application discloses the application of Shaoyao Gancao Decoction in the preparation of a drug for treating chemotherapy-related diarrhea, and belongs to the technical field of medical applications. The application provides the application of Shaoyao Gancao Decoction in the preparation of a drug for treating chemotherapy-related diarrhea, wherein the chemotherapy-related diarrhea is intestinal toxicity diarrhea induced by a chemotherapy drug. Shaoyao Gancao Decoction is a water decoction extract, which is obtained by soaking, reflux extraction, filtration, concentration and drying of Radix Paeoniae Alba and Radix Glycyrrhizae in a weight ratio of 1:1. Shaoyao Gancao Decoction can improve diarrhea symptoms, reduce diarrhea index, reduce perianal pollution, restore intestinal flora diversity, and realize the treatment effect on chemotherapy-related diarrhea by regulating the AhR / NF-κB signal pathway.

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating antibacterial drug related diarrhea. Experiments show that the traditional Chinese medicine composition can obviously improve diarrhea symptoms of mice with antibacterial drug-related diarrhea, reduce loose stool rate, reduce faeces character grading scores, relieve colon tissue pathological damage of the mice with antibacterial drug-related diarrhea, enhance intestinal barrier function and regulate intestinal flora abundance.

The application provides a method for differentiating pathogenic causes of diarrhea after allogeneic hematopoietic stem cell transplantation, and specifically provides application of a reagent for detecting a combination of biological indexes of an individual in preparation of a product for differentiating pathogenic causes of diarrhea after allogeneic hematopoietic stem cell transplantation, wherein the biological indexes include: absolute count of NK cells, CD4 + CD28 + T cells account for CD4 + T lymphocyte percentage; and the detection time point of the biological indexes is within seven days before the diarrhea symptom appears. The method for differentiating pathogenic causes of diarrhea after allogeneic hematopoietic stem cell transplantation provided by the application realizes minimally invasive, low-risk, early and accurate pathogenic cause differentiation by detecting peripheral blood samples and constructing a detection model in combination with multi-time point data.

The invention discloses a preparation method and application of an armillariella tabescens-wolfberry bidirectional fermentation product, and belongs to the technical field of microbial fermentation and treatment of chemotherapy-induced intestinal mucosal lesion. The armillariella tabescens-wolfberry bidirectional fermentation product is prepared from armillariella tabescens mycelia and a basic culture medium added with wolfberry through a bidirectional fermentation technology. Functional evaluation is performed by constructing a 5-FU induced colon cancer tumor-bearing mouse intestinal mucosa injury model, and experimental results show that the armillariella-wolfberry bidirectional fermentation product can remarkably relieve weight loss and diarrhea symptoms of model animals caused by chemotherapy, remarkably reduce the level of diamine oxidase (DAO) in serum and effectively improve intestinal mucosa injury.

The invention discloses a bacterial strain for preventing and treating diarrhea caused by clostridium difficile infection and application of the bacterial strain. The bacterial strain is saccharomyces boulardii HS5 and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.31317. The invention further discloses a preparation method of the bacterial strain for preventing and treating diarrhea caused by clostridium difficile infection and application of the bacterial strain for preventing and treating diarrhea caused by clostridium difficile infection. The preservation time is October 11, 2021; the bacterial strain for preventing and treating diarrhea caused by clostridium difficile infection is obtained through screening, the bacterial strain can remarkably inhibit growth of clostridium difficile, has excellent antibacterial performance on clostridium difficile, can further prevent and improve diarrhea symptoms caused by clostridium difficile infection, and is quick in effect and remarkable in effect.

The invention belongs to the technical field of health care products, and particularly relates to a composition for regulating intestinal flora and a preparation method and application thereof. The composition for regulating the intestinal flora is prepared from the following raw materials in parts by weight: 80 to 120 parts of fried rice flour, 25 to 35 parts of galactomannan, 5 to 15 parts of compound probiotic powder, 3 to 8 parts of pectin, 1 to 3 parts of glutathione and 5 to 10 parts of resistant dextrin. The composition provided by the invention not only can nourish beneficial bacteria through prebiotics, but also can directly supplement the beneficial bacteria through other components, protect intestinal mucosa, reduce inflammation and supplement electrolyte, so that diarrhea symptoms can be quickly improved from multiple targets, and the intestinal microecology can be regulated for a long time.

The invention provides a method for identifying and diagnosing pathogenic causes of diarrhea after transplantation of allogenic hematopoietic stem cells, and particularly provides application of a reagent for detecting a biological index combination of an individual in preparation of a product for identifying the pathogenic causes of diarrhea after transplantation of the allogenic hematopoietic stem cells, the biological indexes comprise the absolute count of NK cells and the percentage of CD4 + CD28 + T cells in CD4 + T lymphocytes; the detection time point of the biological indexes is within seven days before diarrhea symptoms appear. According to the diarrhea pathogenic cause differential diagnosis method after allogenic hematopoietic stem cell transplantation based on immune cell subpopulation and cell factor dynamic monitoring, a detection model is constructed through peripheral blood sample detection in combination with multi-time-point data, and minimally invasive, low-risk, early-stage and accurate pathogenic cause identification is achieved.

This invention belongs to the field of traditional Chinese medicine compositions, specifically relating to a traditional Chinese medicine composition for treating lung heat, its preparation method, and its application. The Xiebai Powder provided by this invention is composed of the following ingredients: Lycium chinense root bark, stir-fried mulberry bark, stir-fried licorice root, japonica rice, pickled apricot kernels, and Pinellia ternata. The formula provided by this invention is both clearing and moistening, purging while also tonifying, and tonifying while dispersing. The addition of pickled apricot kernels and Pinellia ternata makes it more suitable for the immature Yin and Yang constitution of children, addressing both cough and diarrhea symptoms, thus balancing the root cause and the symptoms. It aligns with the characteristics of the lungs being a delicate organ, intolerant to cold and heat, and children's weak spleen and stomach, making them prone to diarrhea and cough, thereby shortening the course of the disease and improving efficacy.

A computer system dealing with digestive health (such as diarrhea) can help guide users to content particularly relevant to their experience without requiring traditional user-input search terms. Such a system can receive user-specific time-series data indicating the user's recorded diet, mood, and diarrhea symptoms. This data can be captured in a daily journaling application on a smartphone. The system can use this data to determine the correlation between the user's recorded diet and mood information and the user's recorded diarrhea symptom information. Appropriate content units can then be selected from multiple content units based on the determined correlation, such as from a database of digestive health information. The selected units can then be presented to the user.

The invention belongs to the field of biological medicine, and particularly relates to a traditional Chinese medicine composition for preventing and treating lamb spleen deficiency diarrhea and preparation and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-20 parts of radix codonopsis, 15-20 parts of radix astragali, 10-15 parts of honey grass, 1-5 parts of fructus amomi, 1-5 parts of poria, 1-5 parts of fructus crataegi and 1-5 parts of rhizoma cibotii. The traditional Chinese medicine composition is fed to diseased lambs according to 1.5 g / (kg.bw), the diarrhea symptom of the lambs can be remarkably improved, and the effective rate reaches 100%. And the traditional Chinese medicine composition has a good effect of preventing and treating lamb spleen deficiency diarrhea, and has the advantages of multiple targets, low residue and good biological safety.

The invention discloses a compound probiotic preparation containing natural extracts and used for treating diarrhea and a preparation method of the compound probiotic preparation. The compound probiotic preparation contains a component A, a component B and a component C. The component A is a fermentation extract, the component B is a schisandra chinensis extract, and the component C is probiotic powder. The compound probiotics, the natural extract and the fermentation extract cooperate with one another, play respective advantages and generate a synergistic effect, and compared with a single probiotic preparation or a natural plant extract, the compound microbial agent provided by the invention shows a remarkable curative effect in the aspect of treating diarrhea, can more quickly relieve diarrhea symptoms, and has a good application prospect. The intestinal function recovery is promoted.

The invention relates to a traditional Chinese medicine composition for treating diarrhea and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for treating diarrhea. The traditional Chinese medicine composition comprises Chinese fevervine herb and humifuse euphorbia herb. The mass ratio of the Chinese fevervine herb to the humifuse euphorbia herb is (1-2): (1-2). An escherichia coli infectious diarrhea mouse model is established, the prevention and treatment effects of independent application and combined application of the Chinese fevervine herb and the humifuse euphorbia herb on the escherichia coli infectious diarrhea are evaluated, and results show that the diarrhea symptoms are relieved to different degrees by independent application of the Chinese fevervine herb and the humifuse euphorbia herb, and the Chinese fevervine herb and the humifuse euphorbia herb have a synergistic effect; through combined application, the diarrhea degree can be effectively relieved, the body state can be improved, inflammation caused by diarrhea can be relieved, meanwhile, weight gain can be promoted, and an experimental basis is provided for scientific application of traditional Chinese medicine in prevention and treatment of animal bacterial diarrhea.