8 results about "Cefuroxime axetil" patented technology

The utility model relates to the technical field of airflow mixers, in particular to an airflow mixer for cefuroxime axetil tablets, which comprises a base, a mixing barrel is arranged above the base, the upper surface of the mixing barrel is rotatably connected with a top cover, and a filtering mechanism for conveniently filtering and cleaning powder in exhausted air is arranged at the bottom of the top cover. The fixed frame is fixedly connected to the bottom of the top cover, and the filter cartridge is fixedly connected to the bottom of the fixed frame. According to the airflow mixer for the cefuroxime axetil tablets, the fixed seat mounted at the top of the base is connected with the mixing barrel, meanwhile, the air cylinder arranged on the upper surface of the base is connected with the air pump, and the other end of the airflow pipe connected with one side of the air cylinder is connected with the mixing barrel, so that airflow mixing treatment is conveniently carried out on medicines in the mixing barrel; an exhaust pipe and a bottom groove are arranged on a top cover arranged at the top of the mixing barrel, and a filtering mechanism is arranged at the bottom of the bottom groove, so that air is filtered and filtered medicine powder is swept away when the air in the mixing barrel is exhausted.

The invention relates to the technical field of pharmaceutical wastewater treatment, in particular to a treatment method of cefuroxime sodium production wastewater. The method comprises the following steps: firstly, pretreating the cefuroxime sodium production wastewater, and adjusting the pH value to 5.0-7.5; putting the porous magnetic catalytic aerogel into the pretreated wastewater, and performing mixed treatment while performing sunlight irradiation; and taking out the porous magnetic catalytic aerogel to obtain the treated water. The 24-hour degradation rate of the cefuroxime sodium and the cefuroxime axetil can reach 95% or above, and the COD removal rate exceeds 90%. According to the method disclosed by the invention, efficient degradation treatment of antibiotics and organic matters in the cefuroxime sodium production wastewater is realized by utilizing visible light catalysis and a synergistic mechanism of adsorption, enrichment and degradation.

The application discloses a preparation method of cefuroxime axetil biphasic crystallization and belongs to the technical field of medicine preparation. The method comprises the following steps: step one, adding purified water into an ethyl acetate solution of cefuroxime axetil and stirring; step two, water-bath heating, vacuum distillation and concentration are continued until the vacuum is stopped after crystals are precipitated, the temperature of the crystallization liquid is controlled to be not higher than 20 DEG C, the crystals are stirred and aged, and the precipitated crystals sink into the water phase; step three, water-bath heating, vacuum distillation are continued until 90% of the ethyl acetate is distilled out, the distillation is stopped, and the aging is continued; step four, the aging is finished, the material is discharged, the material is filtered at the same time, the material is stopped when the material is discharged to the interface between the ethyl acetate phase and the water phase, the cefuroxime axetil solid is obtained, the cefuroxime axetil solid is washed with ethanol, the cefuroxime axetil solid is dried, and the cefuroxime axetil is obtained. The crystallization method of the cefuroxime axetil is environment-friendly and efficient, there is no residual isopropyl ether in the product, and the product quality is improved.

The application discloses a kind of cefuroxime axetil direct compression granules and its preparation process, the preparation process includes the following steps: step (1) preparation of konjac glucomannan-microcrystalline cellulose complex;Step (2) preparation of intermediate;Step (3) preparation of direct compression granules and the like steps.The cefuroxime axetil direct compression granules prepared in the application can effectively mask the bitter taste of cefuroxime axetil, while improving the dissolution and controlling the dissolution rate of cefuroxime axetil drug, thereby improving the bioavailability of cefuroxime axetil drug, etc., and the corresponding preparation process is simple, can save coating step, etc., suitable for large-scale production in industry.

The invention relates to the technical field of cefuroxime axetil, in particular to a taste masking method of a cefuroxime axetil medicine. Slowly dropwise adding the lavender plant essential oil into the mixed solution; for patients, especially children and people sensitive to odors, unpleasant odors such as bitter smell and fishy smell of cefuroxime axetil can cause the patients to generate an inimical emotion on medicine taking, so that the patients do not take the medicine on time or refuse to take the medicine, and after the lavender plant essential oil is added into a microcapsule wall material solution, the lavender plant essential oil has pleasant fragrance, so that the lavender plant essential oil has a good effect on preventing and treating diseases. According to the cefuroxime axetil pharmaceutical composition, the unpleasant odor of a medicine can be covered, the medication compliance of a patient is improved, and especially for children and people sensitive to taste, the conflict emotion of the patient to cefuroxime axetil can be reduced; components in the lavender plant essential oil can reduce the surface tension of the micro-capsule wall material solution, so that the micro-capsule wall material solution is easier to spread and attach, and the lavender plant essential oil has anti-inflammatory and soothing effects, so that the use effect of the cefuroxime axetil after production is improved.

The invention relates to the technical field of cefuroxime axetil production, and provides a mixing device for cefuroxime axetil production, the mixing device comprises a mixing cylinder assembly I, a mixing cylinder assembly II and a cefuroxime axetil pretreatment mechanism, the mixing cylinder assembly I is used for preparing a qualified cefuroxime axetil coating particle primary product, and the mixing cylinder assembly II is used for preparing a cefuroxime axetil coating particle secondary product; the mixing cylinder assembly II is used for mixing and seasoning the qualified cefuroxime axetil coated particle primary product to form a cefuroxime axetil dry suspension final product; the cefuroxime axetil pretreatment mechanism is used for hammering, grinding and screening cefuroxime axetil powder; the cefuroxime axetil pretreatment mechanism comprises a pretreatment barrel, and a hammering assembly, a rolling and grinding assembly and a screening assembly are arranged in the pretreatment barrel. By arranging the cefuroxime axetil pretreatment mechanism, triple functions of hammering, grinding and screening are integrated, the problems of caking and uneven particle size of the cefuroxime axetil raw material are effectively solved, and a raw material basis with uniform particle size is provided for a subsequent coating procedure.

The present application relates to the technical field of pharmaceutical wastewater treatment, and relates to a treatment method of cefuroxime sodium production wastewater. First, the cefuroxime sodium production wastewater is pretreated, and the pH is adjusted to 5.0-7.5; the porous magnetic catalytic aerogel is put into the pretreated wastewater, and mixed treatment is carried out while sunlight irradiation; the porous magnetic catalytic aerogel is taken out, and the treated water is obtained. The 24-hour degradation rate of the cefuroxime sodium and cefuroxime axetil can reach more than 95%, and the COD removal rate is more than 90%. The present application realizes the efficient degradation treatment of antibiotics and organic matters in the cefuroxime sodium production wastewater by using visible light catalysis and through the synergistic mechanism of 'adsorption-enrichment-degradation'.

The invention discloses amorphous cefuroxime axetil heavy powder and a preparation method thereof.The preparation method comprises the following steps that S1, crystalline cefuroxime axetil is dissolved in a composite solvent, the dissolving temperature is controlled, and the composite solvent comprises acetone and water; s2, adding a surfactant and a polymer carrier into the solution in the step S1, and stirring and dissolving to obtain a mixed solution; and S3, carrying out spray drying on the mixed solution to obtain the amorphous cefuroxime axetil heavy powder, the invention develops the preparation method of the amorphous cefuroxime axetil heavy powder, solves the problems that the amorphous cefuroxime axetil obtained by spray drying is low in density and large in static electricity, so that subsequent auxiliary materials are not uniformly mixed, and the dissolution rate fluctuation of dry granulation is large, and is more suitable for industrial production.