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Cefuroxime axetil dispersible tablet and its preparation method

A technology of cefuroxime axetil and dispersible tablets, applied in the directions of pill delivery, antibacterial drugs, etc., can solve problems such as low dissolution rate, and achieve the effects of reducing energy consumption, improving bioavailability and curative effect, and improving production efficiency

Inactive Publication Date: 2012-06-13
山东淄博新达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of cefuroxime axetil dispersible tablet and preparation method thereof, can solve the bitter taste defect of tablet, and provide a kind of reasonable and effective production technology, solve the problem of low dissolution rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take the production of 1000 pieces of cefuroxime axetil dispersible tablets with a specification of 250 mg as an example:

[0031] Cefuroxime axetil 250g;

[0032] Magnesium stearate 4g;

[0033] Microcrystalline cellulose PH-102 250g;

[0034] Aspartame 15g;

[0035] Croscarmellose Sodium 28g;

[0036] Essence 10g;

[0037] Silica 5g;

[0038] Sodium Lauryl Sulfate 2g.

[0039] Preparation:

[0040] Pass the above raw materials through a 40-mesh sieve, mix aspartame with microcrystalline cellulose PH-102 of the same weight for 5 minutes, then add all the croscarmellose sodium and mix for 5 minutes, the mixed powder and the remaining raw materials Drop in the mixing barrel, mix for 20 minutes, and finally press the tablet with a high-speed rotary tablet press to obtain the cefuroxime axetil dispersible tablet.

[0041] Select 6 at random to test the dissolution rate of dispersible tablet:

[0042] time

Embodiment 2

[0044] Take the production of 1000 pieces of cefuroxime axetil dispersible tablets with a specification of 250 mg as an example:

[0045] Cefuroxime axetil 250g;

[0046] Magnesium stearate 10g;

[0047] Microcrystalline cellulose PH-102 350g;

[0048] Aspartame 25g;

[0049] Croscarmellose Sodium 56g;

[0050] Essence 50g;

[0051] Silica 20g;

[0052] Sodium Lauryl Sulfate 10g.

[0053] Preparation:

[0054] Pass the above raw materials through a 40-mesh sieve, mix aspartame with microcrystalline cellulose PH-102 of the same weight for 5 minutes, then add all the croscarmellose sodium and mix for 5 minutes, the mixed powder and the remaining raw materials Drop in the mixing barrel, mix for 20 minutes, and finally press the tablet with a high-speed rotary tablet press to obtain the cefuroxime axetil dispersible tablet.

[0055] Select 6 at random to test the dissolution rate of dispersible tablet:

[0056] time

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Abstract

The invention belongs to the medicine preparation field, more specifically relates to a Cefuroxime axetil dispersible tablet and its preparation method, the dispersible tablet comprises the following raw materials: Cefuroxime axetil, magnesium stearate, microcrystalline cellulose PH-102, aspartame, cross linked sodium carboxymethyl cellulose, essence, silica and sodium dodecyl sulfate. The method comprises the following steps: passing the above raw materials through a sieve with 40 meshes, mixing the aspartame and microcrystalline cellulose PH-102 with equal weight for 5 minutes, then adding all the cross linked sodium carboxymethyl cellulose for mixing for 5 minutes, placing the mixed powder and residual raw materials in a mixed tank, mixing for 20 minutes, tabletting by a high speed rotary tablet machine to obtain the Cefuroxime axetil dispersible tablet. The dissolution rate of the prepared Cefuroxime axetil dispersible tablet can reach more than 90% after 15 minutes, 99.5% after 45 minutes, thereby the biological availability and curative effect of the medicines can be fully enhanced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a cefuroxime axetil dispersible tablet and a preparation method thereof. Background technique [0002] Cefuroxime axetil (CXMIA), as a second-generation cephalosporin, has broad-spectrum antibacterial properties and is active against both Gram-positive and Gram-negative bacteria. It is the prodrug of cefuroxime, and after oral administration, it is rapidly hydrolyzed by non-specific esterase in the mucosal cells of the gastrointestinal tract to release cefuroxime to exert its drug effect. Cefuroxime axetil is a lipophilic drug with poor water solubility, difficulty in absorption, low bioavailability, and dissolution rate is the limiting factor for drug absorption. After administration, the dissolution and absorption in the digestive tract are poor, resulting in reduced bioavailability and curative effect. [0003] Making cefuroxime axetil into dispersible tablets can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/546A61K47/38A61P31/04
Inventor 楚春锋王烜贾法强梁蓓
Owner 山东淄博新达制药有限公司
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