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Cefuroxime axetil taste masking pellet and method of preparing the same

A technology of cefuroxime axetil and taste-masked pellets, applied in sugar-coated pills, pill delivery, pharmaceutical formulations and other directions, can solve problems such as bitter taste, poor water solubility, and unfavorable drug administration for children

Inactive Publication Date: 2008-04-02
莫敬柱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cefuroxime axetil raw material is unstable to humidity and heat, has poor water solubility, aggregates in water, and has a very bitter taste. Therefore, there is no cefuroxime axetil dosage form suitable for children on the market, which is unfavorable for children's administration.

Method used

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  • Cefuroxime axetil taste masking pellet and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] ① Preparation of blank pellet core

[0041] Adjust the position and angle of the mixing knife and the spray gun. The position of the mixing knife should make the material rotate in a vortex shape in the pelletizing pot, so that the atomization fan of the spray gun can reach the maximum. At the beginning, the feeding amount of microcrystalline cellulose was 300g, and the water spray flow rate changed with the granulation time. Initially, it was 27mL / min high-flow water spray, and the speed of the spray pump was 90r / min, so that the microcrystalline cellulose powder was granulated in a short time. Moisten to keep it from flying up. Then control the water spray flow at a medium speed, adjust the speed of the spray pump to 75r / min, and continue to operate for 4min, then reduce the water spray flow, adjust the speed of the spray pump to 60r / min, and continue for 8min, the final stage is microcrystalline fiber In the powder supply stage, control the ratio of microcrystalline...

Embodiment 2

[0062] ① Preparation of blank pellet core

[0063] Adjust the position of the mixing knife and the position of the spray gun. The position of the spray gun should make the spray gun and the material form the largest atomization fan in the material chamber, that is, the angle between the spray gun and the material is ≤90°; Vortex back rotation. Adjust the air injection pressure to 015mPa, the air injection flow rate to 13-15L / min, and the feeding amount of microcrystalline cellulose is 300g at the beginning, and the water injection flow rate changes with the granulation time. Initially, it is 27mL / min large-flow spraying, and the speed of the spraying pump is 90r / min, so that the powder is wetted in a short time to avoid dust flying. Then control the water spray flow at a medium speed, adjust the spray pump speed to 75r / min, and continue to operate for 4min, then reduce the spray flow, adjust the spray pump speed to 60r / min and continue for 8min. The final stage is the micro...

Embodiment 3

[0077] ① Preparation of blank pellet core

[0078] Adjust the position of the mixing knife and the position of the spray gun. The position of the spray gun should make the spray gun and the material form the largest atomization fan in the material chamber, that is, the angle between the spray gun and the material is ≤90°; Vortex back rotation. Adjust the air injection pressure to 0.5mPa, the air injection flow rate to 13-15L / min, and the initial feeding amount of microcrystalline cellulose is 300g. The water injection flow rate changes with the granulation time. Initially, it is 27mL / min large-flow spraying, and the speed of the spraying pump is 90r / min, the powder is wetted in a short time to avoid dust flying. Then control the spraying flow at a medium speed, adjust the speed of the spraying pump to 75r / min, continue to operate for 4min, then reduce the spraying flow to 60r / min and continue for 8min, the final stage is the microcrystalline cellulose powder supply stage, con...

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Abstract

The invention relates to a cefuroxime axetil taste masking pellet and the preparation method. The invention contains cefuroxime axetil pill and a taste masking coating layer wrapping the pill. The invention overcomes the shortages of bitter taste with traditional cefuroxime axetil tablet, provides a preparation method of cefuroxime axetil taste masking pellet which masks bitterness, releases drug rapidly and has stable quality.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a cefuroxime axetil taste-masking pellet and a preparation method thereof. Background technique [0002] The pellets prepared in the pharmaceutical industry are all between 500-1500um, and the pellets can be packed into capsules or compressed into tablets for use. Different prescriptions can be used to make the medicine into quick-release, slow-release or controlled-release pellets. Micropellet technology has developed rapidly since the advent of Spansolf in the 1950s. Micropill refers to a small spherical oral dosage form with a diameter of about 1mm, generally no more than 2.5mm. Since the micropill is a dose-dispersed preparation, a dose is composed of multiple units. Compared with a single-dose dosage form, it has the following advantages: (1 ) It can be coated with controlled-release pellets to make sustained-release preparations; (2) It can increase the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/546A61P31/04
CPCY02A50/30
Inventor 莫敬柱
Owner 莫敬柱
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