The invention discloses a preparation method of high-performance silicon dioxide grease, which comprises the following components, base oil of 70 to 90 weight percent, silica of 5 to 30 weight percent, modifying agent is in a dose of 5-30 weight percent of the silicon dioxide. The silicon dioxide grease of the invention has a very good storage stability and shear stability, good colloidal stability, water resistant properties of high temperature and low temperature performance. The silicon dioxide grease can be used for electrical insulation, damping system lubrication, vacuum sealed, instruments and cock sealing and lubricating, can also be used for resistant chemical media site lubricating and sealing, and so on. In addition, the silicon dioxide grease can also be used for preparing valves grease, methanol resistance grease, and is applicable in lubrication and interrupter of the metal contact of switch silvering, silver plating, and tinning and other.