Cefuroxime oral antibacnterial composition

The technology of cefuroxime axetil and antibacterial composition is applied in the field of oral antibacterial composition of anti-β-lactamase antibiotics, which can solve the problems of decreased antibacterial effect and the like, and achieve the effect of excellent antibacterial effect

Inactive Publication Date: 2006-03-08
夏中宁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the widespread clinical application of cefuroxime axetil, some strains that were originally sensitive to cefuroxime have developed resistance to cefuroxime, reducing its antibacterial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Cefuroxime axetil oral antibacterial composition is made up of cefuroxime axetil and sulbactam pivoxil, and the weight ratio of cefuroxime axetil (in cefuroxime) and sulbactam pivoxil (in sulbactam) is 1:1.

Embodiment 2

[0013] Cefuroxime axetil oral antibacterial composition is made up of cefuroxime axetil and sulbactam pivoxil, and the weight ratio of cefuroxime axetil (in cefuroxime) and sulbactam pivoxil (in sulbactam) is 2:1.

Embodiment 3

[0015] Cefuroxime axetil oral antibacterial composition is made up of cefuroxime axetil and sulbactam pivoxil, and the weight ratio of cefuroxime axetil (in cefuroxime) and sulbactam pivoxil (in sulbactam) is 4:1.

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PUM

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Abstract

The present invention discloses an oral antimicrobial medicine composite composed of cefuroxime axetil and sulbactam pivoxil. The weight ratio range of cefuroxime axetil (by cefuroxime) and sulbactam pivoxil (by sulbactam) is 1:1 to 15:1, the optimum weight ratio range is 2:1.

Description

technical field [0001] The invention relates to a compound antibacterial drug, which is an anti-beta-lactamase antibiotic oral antibacterial composition. Background technique [0002] Cefuroxime Axetil is a second-generation cephalosporin. As a broad-spectrum bactericidal antibiotic, it has strong antibacterial effect on Gram-positive bacteria and most Gram-negative bacteria. , Low nephrotoxicity. With the wide application of cefuroxime axetil in clinical practice, some originally sensitive strains have developed resistance to cefuroxime, making its antibacterial effect decline. Studies have found that the main mechanism of bacterial resistance to cephalosporins is to produce specific β-lactamase to decompose drugs. [0003] In order to overcome the drug resistance caused by β-lactamase-producing bacteria, we began to develop an anti-β-lactamase antibiotic oral antibacterial composition composed of cefuroxime axetil and sulbactam pivoxil, and achieved certain results. Tes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04A61K31/43
Inventor 刘全胜夏中宁舒军林学良
Owner 夏中宁
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