Pharmaceutical composition of cefuroxime axetil for suspension and preparation method thereof

A technology of cefuroxime axetil and dry suspension, which is applied in the direction of pharmaceutical formulations, antibacterial drugs, and medical preparations containing active ingredients, etc. It can solve the problem of inappropriateness, reduce the compliance of patients with clinical medication, and cannot effectively cover up the bitter taste, etc. problem, achieve the effect of improving bitterness and improving compliance

Inactive Publication Date: 2012-05-09
SHANDONG LUKANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional dosage forms such as tablets and capsules are not suitable for children, elderly patients and patients who have difficulty swallowing
And cefuroxime axetil is a kind of very bitter medicine, adding essence, sweetener and other conventional methods cannot effectively cover up the bitter taste, which makes patients resist the medicine and reduces the compliance of patients in clinical medicine.

Method used

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  • Pharmaceutical composition of cefuroxime axetil for suspension and preparation method thereof
  • Pharmaceutical composition of cefuroxime axetil for suspension and preparation method thereof
  • Pharmaceutical composition of cefuroxime axetil for suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of cefuroxime axetil dry suspension:

[0046] Quantity per 1000 bags

[0047]

[0048]

[0049] Preparation:

[0050] (1) Pass the raw and auxiliary materials through a sieve of 80 mesh (except stearic acid).

[0051] (2) Mix the prescribed amount of sucrose ① and cefuroxime axetil through an 80-mesh sieve, and mix evenly. Melt the prescribed amount of stearic acid at 55-80°C, add a uniform mixture of cefuroxime axetil and sucrose, stir evenly, cool at room temperature, and pulverize until the particle size is between 30-80 mesh.

[0052] (3) Add the remaining prescription amount of auxiliary materials and mix evenly.

[0053] (4) Divide into dry suspension.

Embodiment 2

[0055] Preparation of cefuroxime axetil dry suspension:

[0056] Quantity per 1000 bags

[0057]

[0058]

[0059] Preparation:

[0060] (1) Pass the raw and auxiliary materials through a sieve of 80 mesh (except stearic acid).

[0061] (2) Mix the prescribed amount of sucrose ① and cefuroxime axetil through an 80-mesh sieve, and mix evenly. Melt the prescribed amount of stearic acid at 55-80°C, add a uniform mixture of cefuroxime axetil and sucrose, stir evenly, cool at room temperature, and pulverize until the particle size is between 30-80 mesh.

[0062] (3) Add the remaining prescription amount of auxiliary materials and mix evenly.

[0063] (4) Divide into dry suspension.

Embodiment 3

[0065] Preparation of cefuroxime axetil dry suspension:

[0066] Quantity per 1000 bags

[0067]

[0068]

[0069] Preparation:

[0070] (1) Pass the raw and auxiliary materials through a sieve of 80 mesh (except stearic acid).

[0071] (2) Mix the prescribed amount of sucrose ① and cefuroxime axetil through an 80-mesh sieve, and mix evenly. Melt the prescribed amount of stearic acid at 55-80°C, add the homogeneous mixture of cefuroxime axetil and sucrose, stir evenly, cool at room temperature, and pulverize until the particle size is between 30-80 mesh.

[0072] (3) Add the remaining prescription amount of auxiliary materials and mix evenly.

[0073] (4) Divide into dry suspension.

[0074] The invention adopts the melting and cooling method to prepare the cefuroxime axetil dry suspension medicinal composition, which effectively covers the bitter taste of the cefuroxime axetil and improves the clinical medication compliance of patients.

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PUM

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Abstract

The invention relates to a pharmaceutical composition of cefuroxime axetil for suspension for pharmaceutical purposes and a preparation method thereof. The pharmaceutical composition of the cefuroxime axetil for suspension disclosed by the invention comprises 100 parts by weight of cefuroxime axetil (calculating according to the weight of cefuroxime), 50-250 parts by weight of cane sugar and 400-650 parts by weight of stearic acid. The invention further provides the method for preparing the composition. According to the pharmaceutical composition for suspension disclosed by the invention, the bitter taste of the cefuroxime axetil is effectively covered up; and the pharmaceutical composition is applied to adults, more importantly, the problem for difficultly taking medicines of children, old people and patients suffering from dysphagia is solved, and the compliance of medicine taking patients is greatly increased.

Description

technical field [0001] The invention relates to a medical cefuroxime axetil dry suspension and a preparation method thereof Background technique [0002] Dry suspension is a new dosage form of fine particles developed on the basis of suspension, which is stored in solid form and taken orally in the form of suspension. The dry suspension has uniform particle distribution, good stability, fast absorption, fast onset of action and high bioavailability. When the dry suspension is mixed with water, it forms a suspension solution similar to syrup, which has a good taste and is readily accepted by patients. It is not only suitable for adults, but also especially suitable for infants, children, the elderly and patients with dysphagia. Therefore, dry suspension is a promising dosage form worthy of research and development. [0003] Cefuroxime axetil is a macrolide antibiotic, easily soluble in acetone, soluble in chloroform, slightly soluble in methanol or ethanol, slightly soluble...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/546A61P31/04
Inventor 吴大颖何仲贵王文笙张菊红吴秋娜郑霞霞李伦波康等贵
Owner SHANDONG LUKANG PHARMA
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