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Cefuroxime axetil dispersible tablet

A technology of cefuroxime axetil and dispersible tablets, applied in the directions of pill delivery, antibacterial drugs, etc., can solve the problems of high bitterness of cefuroxime axetil, unfavorable for patients to take, low production efficiency, etc., achieve uniform dissolution, improve compliance, Well-formulated effect

Inactive Publication Date: 2014-06-11
LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the wet granulation process has the disadvantages of low production efficiency and high energy consumption. Moreover, after wet granulation, the dissolution rate is still low and affects stability.
In addition, cefuroxime axetil has a bitter taste, which is not conducive to patients taking

Method used

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  • Cefuroxime axetil dispersible tablet
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  • Cefuroxime axetil dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of Cefuroxime Axetil Dispersible Tablets

[0024] cefuroxime axetil 150.5g microcrystalline cellulose 77.5g Crospovidone 24g silica 0.15g Sodium dodecyl sulfate 3g stearic acid 18g aspartame 18g Orange Powder Flavor 6g production 1000 pieces

[0025] Opadry y-1-7000 1.5g water 11g 12% aqueous solution is coating liquid

[0026] Preparation:

[0027] Determination of the particle size of cefuroxime axetil raw material requires its particle size d 90 ≤70 μm, pass the cefuroxime axetil raw material through a 100-mesh sieve, and the auxiliary materials through a 80-mesh sieve, and set aside; weigh cefuroxime axetil, microcrystalline cellulose, sodium lauryl sulfate, aspartame, Orange powder flavor, mixed with 50% prescription amount of crospovidone, silicon dioxide, and stearic acid, and mixed for 30 minutes to make it evenly...

Embodiment 2

[0028] Example 2 Preparation of Cefuroxime Axetil Dispersible Tablets

[0029] cefuroxime axetil 3010g microcrystalline cellulose 1550g Crospovidone 480g silica 60g Sodium dodecyl sulfate 60g stearic acid 360g aspartame 360g Orange Powder Flavor 12g production 20000 pieces

[0030] Opadry y-1-7000 182g water 1335g 12% aqueous solution is coating liquid

[0031] The preparation method is the same as in Example 1.

Embodiment 3

[0032] Example 3 Preparation of Cefuroxime Axetil Dispersible Tablets

[0033] cefuroxime axetil 40g microcrystalline cellulose 20g Crospovidone 5.0g silica 0.15g Sodium dodecyl sulfate 0.5g stearic acid 3.0g aspartame 2.0g Orange Powder Flavor 0.5g production 250 tablets

[0034] Coating Solution Prescription:

[0035]

[0036] The preparation method is the same as in Example 1.

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Abstract

The invention provides a cefuroxime axetil dispersible tablet. The cefuroxime axetil dispersible tablet prepared by the invention can be released within a short time; the formula is reasonable; bitter taste of the cefuroxime axetil dispersible tablet is masked; the mouth feel of the cefuroxime axetil dispersible tablet is improved; the medicinal compliance is improved; furthermore, the preparation process is simple and feasible, strong in operability and steady in process; the bioavailability and the curative effect of the cefuroxime axetil dispersible tablet disclosed by the invention are increased.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a cefuroxime axetil dispersible tablet and a preparation method thereof. Background technique [0002] Cefuroxime axetil is the prodrug of the antibiotic cefuroxime for injection, also known as cefuroxime tetrazole formate and cefuroxime axetil. It belongs to the second generation of cephalosporin antibiotics; it has broad-spectrum and strong bactericidal effect , It has intrinsic stability to β-lactamase, and has good human pharmacokinetics and other characteristics. The esterification of cefuroxime increases the lipophilicity of the drug, improves the pharmacokinetic properties, and relatively prolongs the sterilization time, making it a first-line oral anti-infective drug in clinical practice. [0003] According to reports, among the 100 best-selling prescription drugs in the world in 2001, there were only 9 antibiotics, of which only 2 were cephalosporins, and cefu...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61P31/04
Inventor 关屹闫冬
Owner LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH
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