Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefuroxime axetil hot-melt coating composition and preparation method of composition

A technology for heating cefuroxime axetil and nitrofuran, which is applied in the field of medicine, can solve problems such as destroying the integrity of the coating layer, and achieve the effects of easy continuous large-scale production, simple preparation method and short heating time

Active Publication Date: 2014-06-25
GUANGDONG PHARMA UNIV
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method also uses stearic acid as a taste-masking agent to cooperate with sucrose to coat the drug to improve the bitter taste, but it is limited to granulation in a pulverized manner, which seriously damages the integrity of the coating layer. The dry suspension pharmaceutical composition is dispersed in water and then When taken orally, the bitter taste of the drug is not effectively masked

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefuroxime axetil hot-melt coating composition and preparation method of composition
  • Cefuroxime axetil hot-melt coating composition and preparation method of composition
  • Cefuroxime axetil hot-melt coating composition and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of taste-masked cefuroxime axetil hot-melt coating composition and dry suspension

[0037] The ingredients of the cefuroxime axetil hot-melt coating composition are (1000 parts, each containing 0.125 g of cefuroxime): cefuroxime axetil (calculated as cefuroxime) 125 g, stearic acid 480 g, polyvinylpyrrolidone K30 17.5 g, xanthan gum 20g, sucrose 2900g, black currant essence 20g.

[0038] The preparation method of cefuroxime axetil hot-melt coating composition and dry suspension:

[0039] (1) Mix the prescribed amount of stearic acid and polyvinylpyrrolidone K30 evenly, heat and melt, then add the prescribed amount of cefuroxime axetil, after the dispersion is uniform, spray and freeze to granulate, the atomization pressure is 0.1~2bar, and the inlet air temperature -10~10℃.

[0040] (2) Mix the composition obtained in step (1) with xanthan gum and sucrose evenly, granulate in a fluidized bed, dry, add blackcurrant essence, and mix evenly to...

Embodiment 2

[0041] Example 2 Preparation of taste-masked cefuroxime axetil hot-melt coating composition and dry suspension

[0042] The ingredients of the cefuroxime axetil hot-melt coating composition are (1000 parts, each containing 0.125 g of cefuroxime): 125 g of cefuroxime axetil (calculated as cefuroxime), 360 g of glyceryl behenate, polyvinylpyrrolidone K12 20g, xanthan gum 20g, sucrose 2900g, black currant essence 20g.

[0043] The preparation method of cefuroxime axetil hot-melt coating composition and dry suspension:

[0044] (1) Mix the prescribed amount of glyceryl behenate and polyvinylpyrrolidone K12 evenly, heat and melt, then add the prescribed amount of cefuroxime axetil, after the dispersion is uniform, spray and freeze to granulate, the atomization pressure is 0.1~2bar, and carry out Wind temperature -10~10℃.

[0045] (2) Mix the composition obtained in step (1) with xanthan gum and sucrose evenly, granulate in a fluidized bed, dry, add blackcurrant essence, and mix e...

Embodiment 3

[0046] Example 3 Preparation of taste-masked cefuroxime axetil hot-melt coating composition and dry suspension

[0047] The ingredients of the cefuroxime axetil hot-melt coating composition are (1000 parts, each containing 0.125 g of cefuroxime): cefuroxime axetil (calculated as cefuroxime) 125 g, stearic acid 690 g, polyvinylpyrrolidone K30 10 g , polyvinylpyrrolidone K25 25g, xanthan gum 20g, sucrose 2900g, blackcurrant essence 20g.

[0048] The preparation method of cefuroxime axetil hot-melt coating composition and dry suspension:

[0049] (1) Mix stearic acid, polyvinylpyrrolidone K30 and polyvinylpyrrolidone K12 in the prescribed amount evenly, heat and melt, then add the prescribed amount of cefuroxime axetil, after the dispersion is uniform, spray and freeze to granulate, the atomization pressure is 0.1~ 2bar, inlet air temperature -10~10℃.

[0050] (2) Mix the composition obtained in step (1) with xanthan gum and sucrose evenly, granulate in a fluidized bed, dry, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a cefuroxime axetil hot-melt coating composition and a preparation method of the composition. The cefuroxime axetil hot-melt coating composition can effectively cover up the bitter taste of the medicine, so that the delivery compliance of the patient is improved. Meanwhile, the medicine of the cefuroxime axetil hot-melt coating composition has high dissolution rate in aqueous solvents of different pH values, and the bioavailability of the medicine is high. The composition disclosed by the invention can be further used for preparing a dry suspension or granules, thereby facilitating delivery of infants and children unable to swallow. The composition disclosed by the invention is simple in preparation method, free from any solvents, uniform in medicine content, short in heated time, less in energy consumption and easy to realize continuous production on a large scale.

Description

technical field [0001] The invention belongs to the field of medical science and technology, and in particular relates to a cefuroxime axetil hot-melt coating composition and a preparation method thereof. Background technique [0002] Cefuroxime axetil, the chemical name is (6R, 7R)-7-[2-furyl (methoxyimino) acetamido]-3-carbamoyloxymethyl-8-oxo-5-thia- 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1-acetoxyethyl ester. Its structural formula is: [0003] [0004] Cefuroxime axetil is a semi-synthetic second-generation cephalosporin, belonging to the β-lactam antibiotics. Clinical studies have shown that it has the advantages of high stability to β-lactamase, broad antibacterial spectrum, strong antibacterial activity and small adverse reactions. Clinically, it is mainly used for acute pharyngitis or tonsillitis in adults, acute otitis media, maxillary sinusitis, acute exacerbation of chronic bronchitis, acute bronchitis, simple urinary tract infection, etc. Pharyng...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/16A61K31/546A61K47/32A61K47/14A61K47/12A61P31/04
Inventor 林华庆余楚钦林的仕邓艳斌陈洁
Owner GUANGDONG PHARMA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com