6 results about "Acetyl bromide" patented technology

This application belongs to the field of biomaterials, specifically relating to an antibacterial polymeric derivative of F127 with terminal modification of acetyl bromide, its preparation method, and its application. This application obtains F127AcBr by terminal modification of polymeric F127 with acetyl bromide via an acylation reaction. Its good antibacterial effect and biocompatibility were verified in vitro using plate antibacterial assays against Staphylococcus aureus and Escherichia coli, as well as live / dead staining assays of L929 cells and HUVEC cells. This application optimized the concentration of F127AcBr and loaded it into an MS hydrogel system. Excellent biocompatibility was confirmed in a diabetic mouse wound model using HE staining of mouse organs. Immunofluorescence staining against Staphylococcus aureus further confirmed the good antibacterial activity of F127AcBr.

The application discloses a fluorescent probe and a preparation method and application thereof, and belongs to the technical field of fluorescent detection and rapid detection of pesticide residues. The fluorescent probe provided by the application takes hydroxyl semi-florocyanine as a fluorescent mother nucleus and acetyl as a recognition site; an intermediate NS-OH is subjected to a substitution reaction with acetyl bromide; the obtained fluorescent probe NS-A can detect acetylcholinesterase and can also be combined with an enzyme inhibition method to detect pesticide residues in traditional Chinese medicinal materials; a standard curve is drawn by a fluorescence spectrum method to quantitatively determine the pesticides, and the result shows that the standard curve error of the pesticide chlorpyrifos is small, the pesticide standard addition recovery rate in the traditional Chinese medicinal materials is between 96.03% and 102.57%, and the detection lower limit of the pesticide can reach the required detection standard; the fluorescent probe has the advantages of low cost, high sensitivity, good selectivity and the like, and has a good application prospect.

The present application belongs to the field of environmental remediation and biotechnology, and discloses a modified corncob, a preparation method and application thereof. The present application uses a mixed solution of NaOH and acetyl bromide to modify the corncob. The modification process removes lignin in the corncob through alkalization pretreatment, improves the porosity and specific surface area of the corncob, and simultaneously uses acetyl bromide treatment to enhance the adsorption capacity and immobilization efficiency of the corncob to microalgae. The modified corncob can cross-link with exogenous polymers (EPS) secreted by microalgae, so that the microalgae can stably adhere and survive for a long time, and the application effect of the microalgae in wastewater treatment and ecological remediation is improved. The present application provides an efficient and sustainable biological immobilization technology, and provides a new technical path for water pollution control and ecological remediation, and has a wide application prospect.

The invention provides a preparation method of a rapid photocuring cellulose-based macromolecular photoinitiator. According to the method, 2, 4, 6-trimethylbenzoyl phenylphosphonic acid is used as an initial molecule, an acylating chlorination intermediate with high reactivity is generated through oxalyl chloride activation, then the acylating chlorination intermediate and a cellulose main chain are subjected to a bonding reaction, and effective grafting of a photosensitive structure to a natural polymer skeleton is achieved. Then, esterification regulators such as acetyl bromide and the like are introduced, so that the arrangement and density of the grafting groups on the surface of the cellulose can be further improved, and the esterified cellulose photoinitiator with a uniform functionalization degree is obtained. The obtained initiating material shows good solubility and system adaptability in various acrylate monomers, and can rapidly initiate chain polymerization under ultraviolet irradiation, so that a formula system is converted into a curing network with a bonding function within an extremely short time. The acrylate material initiated by the photoinitiator can be cured within seconds to minutes under a common 365 nm light source. Compared with a small molecular initiator, the macromolecular structure effectively reduces the migration risk, avoids complex operation steps, has the advantages of clean raw materials, high safety, capability of being matched with various monomer systems and the like, and remarkably widens the utilization range of cellulose in the fields of photocuring adhesives and functional resin materials.

The invention provides a synthetic method of acetyl bromo-uridine triphosphate. The method for preparing acetyl bromo-uridine triphosphate has the advantages of good process stability, high reaction efficiency, few side reactions and high purity of a target compound. The method disclosed by the invention is suitable for preparing acetyl bromo-uridine triphosphate in a large scale.

The invention provides a synthesis method of a phenylpropanoid glycoside compound coniferin B. The synthesis method comprises the following steps: dissolving vanillin in dichloromethane, adding acetyl bromide-alpha-D-glucose, tris [2-(2-methoxyethoxy) ethyl] amine, adding a saturated potassium carbonate solution, carrying out a reflux reaction, adding (1, 3-dioxocyclopentyl-2-methyl) triphenylphosphonium bromide, and carrying out quenching, extraction, washing, drying and filtration after the reaction to obtain the phenylpropanoid glycoside compound coniferin B. Dichloromethane is removed in a rotary mode, column chromatography separation is conducted, and a trans compound 2 and a cis compound 3 are obtained; and dissolving the trans-compound 2 in methanol, adding sodium methoxide, adjusting the pH value after reaction, performing rotary evaporation, dissolving the obtained compound 4 in tetrahydrofuran, adding lithium aluminum hydride and aluminum chloride for reaction, quenching, filtering, washing with a methanol solution during suction filtration, performing rotary drying on methanol, and performing column chromatography separation to obtain the phenylpropanoid glycoside compound coniferin B. The invention also provides application of the compound. The compound is used for preparing a medicine for activating latent HIV virus activity. The method is short in chemical process, low in loss, convenient to operate, simple in reaction condition and suitable for production.