11 results about "Acetyl bromide" patented technology

This application belongs to the field of biomaterials, specifically relating to an antibacterial polymeric derivative of F127 with terminal modification of acetyl bromide, its preparation method, and its application. This application obtains F127AcBr by terminal modification of polymeric F127 with acetyl bromide via an acylation reaction. Its good antibacterial effect and biocompatibility were verified in vitro using plate antibacterial assays against Staphylococcus aureus and Escherichia coli, as well as live / dead staining assays of L929 cells and HUVEC cells. This application optimized the concentration of F127AcBr and loaded it into an MS hydrogel system. Excellent biocompatibility was confirmed in a diabetic mouse wound model using HE staining of mouse organs. Immunofluorescence staining against Staphylococcus aureus further confirmed the good antibacterial activity of F127AcBr.

A phenylimidazolium-terminated polyethylene glycol (PEG) corrosion inhibitor and antibacterial water treatment agent and its preparation method are disclosed, comprising the following steps: Step 1: dissolving polyethylene glycol and triethylamine in an anhydrous solvent and cooling the solution to form a reaction system; Step 2: slowly adding bromoacetyl bromide to the reaction system and continuing the reaction to obtain a reaction solution; Step 3: diluting the reaction solution with dichloromethane, removing the triethylamine salt, bromoacetyl bromide, and triethylamine by water extraction, and evaporating after extraction to neutrality to obtain a bromoacetyl-terminated PEG intermediate; Step 4: mixing the intermediate with 1-phenylimidazolium and heating to react to obtain a crude product; Step 5: after the reaction is completed, cooling to room temperature, dialysis in ethanol to purify the product and recover unreacted 1-phenylimidazolium, and evaporating the dialysate to remove ethanol to obtain the phenylimidazolium-terminated PEG corrosion inhibitor and antibacterial water treatment agent. This invention achieves the polymerization, water solubility, and composite functionalization of imidazoline corrosion inhibitors.

The invention discloses a synthesis method of an alcohol amine polymer emulsifier for emulsion explosives, which comprises the following steps: (1) carrying out 1, 4 addition reaction on methyl acrylate and acetyl bromide to obtain methyl 3-bromopropionate, and reacting with diethanol amine to generate methyl N, N-dihydroxyethyl-3-aminopropionate; and (2) carrying out esterification reaction on the N, N-dihydroxyethyl-3-amino methyl propionate and polyisobutylene succinic anhydride to prepare the polyisobutylene succinic anhydride-N, N-dihydroxyethyl-3-amino methyl propionate. And (3) carrying out esterification reaction on the polyisobutylene succinic anhydride-N, N-dihydroxyethyl-3-amino methyl propionate and triethanolamine to prepare the alcohol amine polymer emulsifier. According to the invention, the problem of poor product singleness caused by complex molecular configuration of polyalkenyl ester polymer emulsifiers of polyhydric alcohols and polyhydric alcohol amines can be solved, and the problem of large quality fluctuation of the product in industrial production can be controlled. By adopting the new method, the high-quality alcohol amine polymer emulsifier can be continuously and quickly produced, and the produced emulsifier has the characteristics of good emulsifying capacity, high emulsion forming speed and the like.

The application discloses a fluorescent probe and a preparation method and application thereof, and belongs to the technical field of fluorescent detection and rapid detection of pesticide residues. The fluorescent probe provided by the application takes hydroxyl semi-florocyanine as a fluorescent mother nucleus and acetyl as a recognition site; an intermediate NS-OH is subjected to a substitution reaction with acetyl bromide; the obtained fluorescent probe NS-A can detect acetylcholinesterase and can also be combined with an enzyme inhibition method to detect pesticide residues in traditional Chinese medicinal materials; a standard curve is drawn by a fluorescence spectrum method to quantitatively determine the pesticides, and the result shows that the standard curve error of the pesticide chlorpyrifos is small, the pesticide standard addition recovery rate in the traditional Chinese medicinal materials is between 96.03% and 102.57%, and the detection lower limit of the pesticide can reach the required detection standard; the fluorescent probe has the advantages of low cost, high sensitivity, good selectivity and the like, and has a good application prospect.

The present application belongs to the field of environmental remediation and biotechnology, and discloses a modified corncob, a preparation method and application thereof. The present application uses a mixed solution of NaOH and acetyl bromide to modify the corncob. The modification process removes lignin in the corncob through alkalization pretreatment, improves the porosity and specific surface area of the corncob, and simultaneously uses acetyl bromide treatment to enhance the adsorption capacity and immobilization efficiency of the corncob to microalgae. The modified corncob can cross-link with exogenous polymers (EPS) secreted by microalgae, so that the microalgae can stably adhere and survive for a long time, and the application effect of the microalgae in wastewater treatment and ecological remediation is improved. The present application provides an efficient and sustainable biological immobilization technology, and provides a new technical path for water pollution control and ecological remediation, and has a wide application prospect.

The invention provides a preparation method of a rapid photocuring cellulose-based macromolecular photoinitiator. According to the method, 2, 4, 6-trimethylbenzoyl phenylphosphonic acid is used as an initial molecule, an acylating chlorination intermediate with high reactivity is generated through oxalyl chloride activation, then the acylating chlorination intermediate and a cellulose main chain are subjected to a bonding reaction, and effective grafting of a photosensitive structure to a natural polymer skeleton is achieved. Then, esterification regulators such as acetyl bromide and the like are introduced, so that the arrangement and density of the grafting groups on the surface of the cellulose can be further improved, and the esterified cellulose photoinitiator with a uniform functionalization degree is obtained. The obtained initiating material shows good solubility and system adaptability in various acrylate monomers, and can rapidly initiate chain polymerization under ultraviolet irradiation, so that a formula system is converted into a curing network with a bonding function within an extremely short time. The acrylate material initiated by the photoinitiator can be cured within seconds to minutes under a common 365 nm light source. Compared with a small molecular initiator, the macromolecular structure effectively reduces the migration risk, avoids complex operation steps, has the advantages of clean raw materials, high safety, capability of being matched with various monomer systems and the like, and remarkably widens the utilization range of cellulose in the fields of photocuring adhesives and functional resin materials.

The invention relates to a synthesis method of empagliflozin, and belongs to the technical field of raw material medicine preparation. The invention provides a method for synthesizing empagliflozin, which comprises the following steps of: in the presence of an iron catalyst, alkali and a first solvent, carrying out coupling reaction on a compound shown in a formula 4 and bis (pinacol) diborate to generate a compound shown in a formula 3, and in the presence of a supported palladium catalyst, a chiral ligand, alkali and a second solvent, carrying out coupling reaction on the compound shown in the formula 4 and the bis (pinacol) diborate to generate a compound shown in the formula 3. Carrying out glycosylation reaction on the compound in the formula 3 and acetyl bromide-alpha-D-glucose to generate a compound in a formula 2, and carrying out deprotection on the compound in the formula 2 in the presence of a methanol solution of sodium methoxide and ion exchange resin to generate empagliflozin, namely a compound in a formula 1; the method has the advantages of high yield, low cost, economy, environmental protection and the like.

The invention relates to a phenylimidazole-terminated polyethylene glycol corrosion inhibition antibacterial water treatment agent and a preparation method thereof, and the preparation method comprises the following steps: 1, dissolving polyethylene glycol and triethylamine in an anhydrous solvent, and cooling the solution to form a reaction system; step 2, slowly dropwise adding bromoacetyl bromide into the reaction system, and continuously reacting to obtain a reaction solution; step 3, diluting the reaction liquid by using dichloromethane, removing triethylamine salt, bromoacetyl bromide and triethylamine by using water extraction, extracting to be neutral, and evaporating to obtain a bromoacetate-terminated polyethylene glycol intermediate product; 4, mixing the intermediate product with 1-phenylimidazole, and heating for reaction to obtain a crude product; and step 5, after the reaction is finished, cooling to room temperature, dialyzing and purifying a product in ethanol, recovering unreacted 1-phenylimidazole, and evaporating dialysate to remove ethanol, so as to obtain the phenylimidazole-terminated polyethylene glycol corrosion-inhibition antibacterial water treatment agent. According to the invention, high molecular, water dissolution and composite functionalization of the imidazoline corrosion inhibitor are realized.

The invention provides a synthetic method of acetyl bromo-uridine triphosphate. The method for preparing acetyl bromo-uridine triphosphate has the advantages of good process stability, high reaction efficiency, few side reactions and high purity of a target compound. The method disclosed by the invention is suitable for preparing acetyl bromo-uridine triphosphate in a large scale.

The invention provides a synthesis method of a phenylpropanoid glycoside compound coniferin B. The synthesis method comprises the following steps: dissolving vanillin in dichloromethane, adding acetyl bromide-alpha-D-glucose, tris [2-(2-methoxyethoxy) ethyl] amine, adding a saturated potassium carbonate solution, carrying out a reflux reaction, adding (1, 3-dioxocyclopentyl-2-methyl) triphenylphosphonium bromide, and carrying out quenching, extraction, washing, drying and filtration after the reaction to obtain the phenylpropanoid glycoside compound coniferin B. Dichloromethane is removed in a rotary mode, column chromatography separation is conducted, and a trans compound 2 and a cis compound 3 are obtained; and dissolving the trans-compound 2 in methanol, adding sodium methoxide, adjusting the pH value after reaction, performing rotary evaporation, dissolving the obtained compound 4 in tetrahydrofuran, adding lithium aluminum hydride and aluminum chloride for reaction, quenching, filtering, washing with a methanol solution during suction filtration, performing rotary drying on methanol, and performing column chromatography separation to obtain the phenylpropanoid glycoside compound coniferin B. The invention also provides application of the compound. The compound is used for preparing a medicine for activating latent HIV virus activity. The method is short in chemical process, low in loss, convenient to operate, simple in reaction condition and suitable for production.

A process for the preparation of a compound of formula (I), said process includes reacting a compound of formula (V) with a trifluoroacetyl halide at temperatures between 0° C. and 75° C.: where R1 and R2 are hydrogen; R3 is ethyl, or methoxy; Z is R4 or R5, where R4 is iso-propyl, 1-methoxyethyl, (difluoromethoxy)methyl or cyclopropyl; and R5 is —NR6R7, wherein R6 is hydrogen; and R7 is methyl, where the trifluoroacetyl halide is selected from trifluoroacetyl fluoride, trifluoroacetyl chloride or trifluoroacetyl bromide; wherein said process is carried out in the presence of a base; and where the base is selected from pyridine or 4-dimethylaminopyridine.