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Method and device for preparing superfine amorphousn cefuroxime axetil

A cefuroxime axetil and amorphous technology, which is applied in the field of preparation of ultrafine amorphous cefuroxime axetil, can solve the problems of high solvent cost, small particle size, and narrow particle size distribution, and achieve high reaction efficiency and narrow particle size distribution , the effect of uniform particle size

Inactive Publication Date: 2008-10-15
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Description
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AI Technical Summary

Benefits of technology

This new technology allows for quick mixing between materials without requiring expensive equipment or complicated processes like conventional methods. It achieves this by create tiny channels within it through which liquids flow at once while they mix together rapidly. These minute structures help prevent overheated areas from affecting their properties significantly better than before. Additionally, these systems have rapid thermal conductivity, allowing them to efficiently transport fluids throughout the entire process. They don't require any external energy input during operation making them ideal for commercial applications such as chemical manufacturing. Overall, this innovative technology provides technical benefits including improved performance, reduced costs associated with existing technologies, ease of handling, and enhanced safety measures.

Problems solved by technology

Technological Problem addressed in this patents are how to prepare pure amorphously active Ceftorolacton A while minimizing its production costs compared to existing methods such as liquid phase synthesis.

Method used

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  • Method and device for preparing superfine amorphousn cefuroxime axetil
  • Method and device for preparing superfine amorphousn cefuroxime axetil

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preparation example Construction

[0029] A kind of preparation method of superfine amorphous cefuroxime axetil of the present invention, it comprises the following steps:

[0030] Dissolve crystalline cefuroxime axetil in an acetone solvent, wherein the concentration of the solution containing cefuroxime axetil is 1% (w / v) to 20% (w / v) to obtain a cefuroxime axetil solution, and place in storage Tank 11; measure deionized water and place it in storage tank 12, the type of storage tank 12 and storage tank 11 can be the same, the volume ratio of cefuroxime axetil solution to deionized water is: 1:5~1:50, at the reaction temperature At -25°C to 70°C, unscrew the nitrogen valve of the nitrogen tank 15 to adjust the pressure to 0.2MPa, and the two liquids in the storage tank 11 and the storage tank 12 pass through the rotameters 13 and 14 respectively through the solvent feed port A and the The anti-solvent feed port B enters the microreactor 16, and after rapid contact and efficient mixing, a white cefuroxime axet...

Embodiment 1

[0038] Take by weighing crystalline cefuroxime axetil 100g, be dissolved in acetone, obtain cefuroxime axetil solution 100ml, place storage tank 11, measure deionized water 1000ml and place storage tank 12, cefuroxime axetil solution and deionized water The volume ratio is 1:10. At room temperature, two streams of liquid enter from the feed port A and B of the "Y" microreactor respectively. Mix to generate white cefuroxime axetil precipitate, which is discharged from outlet C, filtered, washed, and dried to obtain ultrafine amorphous cefuroxime axetil particles.

[0039] Figure 4 It is the XRD spectrum of crystalline cefuroxime axetil.

[0040] Figure 5 It is the XRD spectrum of the amorphous cefuroxime axetil obtained according to Example 1 of the present invention.

Embodiment 2

[0042] Take by weighing crystalline cefuroxime axetil 100g, be dissolved in acetone, obtain cefuroxime axetil solution 100ml, place storage tank 11, measure deionized water 2000ml and place storage tank 12, cefuroxime axetil solution and deionized water The volume ratio is 1:20. At room temperature, the two streams of liquid enter from the inlets A and B of the "T" microreactor respectively. Mix to generate white cefuroxime axetil precipitate, which is discharged from outlet C, filtered, washed, and dried to obtain ultrafine amorphous cefuroxime axetil particles. From Figure 6 It can be seen from the scanning electron microscope photos that the average particle size is about 400nm, and at least 80% of the particles have a particle size of 300-400nm.

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Abstract

The invention provides a method and a device for making superfine amorphous cefuroxime axetil. The method is as follows: a solution and a desolvation containing cefuroxime axetil are injected into Y-type microreactors or T-type microreactors at the same time respectively through different inlets according to a certain volume ratio; and the solution and the desolvation are quickly and fully mixed inside the microreactors by means of the small size effect of the microreactors. Amorphous cefuroxime axetil can be made through the desolvation precipitation mode which can quickly realize micromixing. The amorphous cefuroxime axetil obtained by the method has small particles, controllable particle diameter, narrow and even particle size distribution, thereby increasing the bioavailability of the amorphous cefuroxime axetil; moreover, the cefuroxime axetil is suitable for industrial production.

Description

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Claims

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Application Information

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Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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