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Nano-silicon dioxide hollow sphere material and method of preparing the same

A technology of nano-silica and hollow spheres, applied in the field of nano-materials, can solve problems that hinder practical use, and achieve the effects of simple operation, good adsorption, and simple reaction conditions

Inactive Publication Date: 2009-01-14
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Huo et al. used 1,3,5-trimethylbenzene (TMB) to carry a small amount of oil-soluble fluorescent molecules to solubilize them in the hydrophobic core of surfactant micelles and prepared fluorescent functionalized core-shell nanoparticles, which can Entering cells through phagocytosis has a good application prospect, but according to this method, the target object needs to be added to the system at the beginning of the synthesis, and the selection of the target object will be subject to a strong acidic reaction conditions and the target must be oil-soluble and water-insoluble, which greatly hinders its practical use

Method used

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  • Nano-silicon dioxide hollow sphere material and method of preparing the same
  • Nano-silicon dioxide hollow sphere material and method of preparing the same
  • Nano-silicon dioxide hollow sphere material and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dissolve 1.0g of F108 and 1.0g of 1,3,5-trimethylbenzene in 30mL of 2M hydrochloric acid system under stirring at 25°C in a constant temperature circulating water bath. After stirring for more than 6 hours to form a milky white milky liquid homogeneous system, add 1.0g of TEOS , after stirring for 6 h, 0.5 mL of dimethyl dimethyl silicate (DMDMS, (CH 3 ) 2 Si(CH 3 O) 2 ) and continued constant temperature stirring for 48h. The resulting liquid was poured into a dialysis membrane with a molecular weight cut off of 14000, put into distilled water and repeatedly replaced with distilled water (once every 6 h) for dialysis for two days. After dialysis, the solution that removes hydrochloric acid or other inorganic ions is dried in an oven at 100°C. The obtained massive solid was calcined at 350° C. for 6 hours to remove the surfactant to obtain a nano-silica hollow sphere material.

Embodiment 2

[0030] Under the condition of constant temperature circulating water bath at 20°C, stir and dissolve 1.0g F108 and 0.5g 1,3,5-trimethylbenzene in 30mL 1M hydrochloric acid system, stir for more than 6h to form a milky white milky liquid homogeneous system, add 1.5g TEOS, After stirring for 12 h, 0.75 mL of dimethyl dimethyl silicate (DMDMS, (CH 3 ) 2 Si(CH 3 O) 2 ) and continued constant temperature stirring for 48h. The resulting liquid was poured into a dialysis membrane with a molecular weight cut off of 14000, put into distilled water and repeatedly replaced with distilled water (once every 6 h) for dialysis for two days. After dialysis, the solution that removes hydrochloric acid or other inorganic ions is dried in an oven at 100°C, and then redissolved in 30mL of 10% H 2 o 2 , adjust the pH to about 3.5, place it in a quartz jacketed beaker, use 25°C circulating water to control the temperature, use two ultraviolet lights with a wavelength of 253nm and a power of 15...

Embodiment 3

[0032] Under the condition of constant temperature circulating water bath at 40℃, stir and dissolve 1.0g F108 and 1.0g TMB in 30mL 0.5M hydrochloric acid system, stir for more than 6h to form a milky white milky liquid homogeneous system, add 1.0g TMOS, stir for 6h, then add 1.0 mL of dimethyl dimethyl silicate (DMDMS, (CH 3 ) 2 Si(CH 3 O) 2 ) and continued constant temperature stirring for 48h. The resulting liquid was poured into a dialysis membrane with a molecular weight cut off of 14000, put into distilled water and repeatedly replaced with distilled water (once every 6 h) for dialysis for two days. After dialysis, the solution that removes hydrochloric acid or other inorganic ions is dried in an oven at 100°C, and then redissolved in 30 mL of 15% H 2 o 2 , adjust the pH value to 3.5, place it in a 100°C oven for 16 hours, and dry the obtained product in an oven at 100°C to obtain a nano-silica hollow sphere material.

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Abstract

The invention relates to a material of a nanometer silica hollow sphere and a synthesizing method thereof, belonging to the technical field of nanometer material. Wherein, a novel material of a nanometer silica hollow sphere is synthesized by the sol-gel method under the guidance of micelle, and is characterized in that the size is super small, particles are distributed evenly (the deviation of the particle size is less than 3 percent), the pore diameter is 5 to 20 nm, the wall thickness is 5 to 20 nm, and the particle size is adjustable. The synthesizing method comprises procedures of self-assembling, monodisperse controlling, dialyzing, drying and removing a template agent, etc. of the silica hollow sphere under the guidance of the micelle. The material has the advantages that the reaction conditions are mild, the operation is simple and easy, and the ultimate material is cheap and easily available. The physicochemical properties of the particle size and the pore diameter, etc. of the material can be modified by changing conditions of the raw material ratio, added expansion reagents, reaction temperatures and reaction time, etc. The nanometer silica hollow sphere has wide application prospect in the field of adsorption, drug sustained release, the catalyst carrier, the microreactor, and cell intervention targeted diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a nanometer silicon dioxide hollow sphere material and a synthesis method thereof. Background technique [0002] Mesoporous silica is of great value as a slow-release material for drugs. When using mesoporous materials as loading media, their morphology also has many effects on performance. Fan and Lei et al. compared the adsorption of different enzymes between traditional SBA-15 materials and rod-shaped SBA-15 with a controlled size, and found that the smaller-sized rod-shaped SBA-15 has more openings, which can greatly improve the immobilization of materials. Enzyme performance. However, materials with a three-dimensional cage structure such as SBA-16 have a small window size, and the loading performance can be improved by increasing the opening size through high-temperature hydrothermal treatment. Although the material loading performance of the thre...

Claims

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Application Information

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IPC IPC(8): C01B33/18
Inventor 余承忠唐嘉伟朱杰王韵华
Owner FUDAN UNIV
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