The invention discloses an infrared multipoint interactive electronic whiteboard system and a whiteboard projection calibration method and belongs to the field of electronic whiteboards. The system comprises a computer, a projector, a projection screen, an infrared camera, an infrared pen, a laser positioning device, the computer internally comprises a background wireless data controller and a foreground multipoint interactor, the background wireless data controller comprises a calibration module, a Bluetooth wireless communication module and a wireless data processing module, and the foreground multipoint interactor comprises a gesture recognition module, a drawing function module, a picture display function module, a video display function module, a PPT (power point) file playing operation module, a PDF (portable document format) file playing operation module, a handwritten input recognition module and a small-window display module. By the system and the method, except for basic functions, control functions of opening, full-screen playing, page turning, free writing and the like of PPT and PDF files are further increased.