21results about How to "Raw material safety" patented technology

The invention discloses a modified isocyanate prepolymer, a preparation method thereof and a degradable biological adhesive, and belongs to the technical field of medical adhesives. The preparation method comprises the following steps: firstly, continuously reacting alcohol with polyhydroxy acid at a certain temperature to obtain a polyester soft segment containing part of hydroxyl and carboxyl functional groups; and adding isocyanate or isocyanate and alcohol into the prepolymer, and reacting to obtain the modified isocyanate prepolymer. And mixing the modified isocyanate prepolymer with a curing agent to obtain the polyurethane biological adhesive. The curing agent is an unsaturated carbonyl compound modified amine curing agent or a polyamine modified polyphenol curing agent. The polyurethane adhesive is applied to adhesion of a wet tissue interface, and during application, the polyurethane biological adhesive is smeared to a tissue part needing to be adhered and sealed, and in-situ curing is realized. The process for preparing the isocyanate prepolymer is simple, and the polyurethane biological adhesive obtained by utilizing the isocyanate prepolymer is easy to degrade and good in wet adhesion.

The application discloses a kind of preparation and application of lime key component extract with the effect of relieving psychological stress, belong to medical technical field.The application uses Rutaceae citrus plant lime as raw material, and water phase crude extract is prepared by washing and juicing, and the residue is extracted by ultrasonic-assisted ethanol to obtain alcohol phase extract, the two phases are combined and concentrated under reduced pressure, then purified by D101 macroporous resin, to obtain extract rich in active ingredients such as tangeretin, geniposide B, neohesperidin, etc.The application has simple process and high extraction efficiency, and the obtained extract is natural in origin and safe in composition.Animal experiments have verified that the extract can significantly improve anxiety-like behavior caused by stress, and the effect of relieving psychological stress is better than that of single hesperidin, and it can also effectively improve abnormal weight loss caused by stress, regulate the level of inflammatory factors in the body, and balance psychological relaxation and physiological protection.The application fills the application gap of lime in the field of psychological stress relief, and provides a new scheme for developing natural and safe stress relief products.

This invention relates to the field of pharmaceutical formulation technology, and discloses a solid dosage form containing merogabarine besylate, its preparation method, and its uses. The solid dosage form provided by this invention includes contents and a shell encapsulating the contents. By weight, the contents consist of 10-30 parts merogabarine besylate and 10-30 parts silicone oil, and the shell consists of 10-20 parts polyacrylic acid resin, 40-60 parts liquid silicone rubber, and 5-15 parts gum arabic. This dosage form has compressive strength that can stably withstand the daily chewing force of humans. During an epileptic seizure, the patient's explosive biting force can break the membrane, triggering a precise and instantaneous release of the drug, achieving immediate drug release during the seizure and avoiding further harm to the patient from prolonged seizures.

The invention discloses a cobalt vacancy regulation hollow multi-shell nickel-cobalt oxide catalyst and a preparation method and application thereof, and the preparation method comprises the following steps: mixing glucose, zinc salt, cobalt salt, nickel salt and water, and carrying out hydrothermal reaction, calcination and etching to obtain the cobalt vacancy regulation hollow multi-shell nickel-cobalt oxide catalyst. According to the preparation method, zinc salt, cobalt salt, nickel salt and glucose are taken as raw materials, metal nickel, cobalt and zinc are crosslinked on polysaccharide through hydrothermal reaction to form a net-shaped structure, carbon and metal zinc on the surface are removed through calcination and etching, and the stable cobalt vacancy regulation hollow multi-shell nickel-cobalt oxide catalyst with the hollow multi-shell structure is formed. The preparation method disclosed by the invention has the advantages of simple process, safe raw materials, low cost, batch production and the like; the prepared cobalt vacancy regulation hollow multi-shell nickel cobalt oxide catalyst has the advantages of good catalytic activity, high degradation efficiency, good stability, strong anti-interference performance, low metal ion leaching rate and the like.

The invention provides a compound preparation for promoting tobacco root growth and application thereof, and belongs to the technical field of tobacco planting.The compound preparation is prepared by mixing 1 * 10 < 6 >-1 * 10 < 11 > ensifer adhesion and 3-5 g of silafeng, the compound preparation is safe and free of pollution and can be applied from tobacco seedling raising to the resettling stage, and the application mode is root irrigation. The compound medicament obviously promotes the growth of tobacco roots, improves the root dry weight, the fresh weight, the longest root length, the root surface area, the root volume, the root activity and the like, and is beneficial to improving the tobacco quality.

The invention relates to a method for continuously preparing 1, 2-propylene glycol and 1, 3-propylene glycol and application of the method, and belongs to the field of preparation of propylene glycol. In a hydroformylation reaction unit, vinyl acetate, synthesis gas and a first catalyst are subjected to a contact reaction; cooling a part of the hydroformylation reaction product, returning to the hydroformylation reaction to control the reaction temperature, and carrying out pressure reduction on the other part of the reaction product to separate out crude acetoxypropionaldehyde; the crude acetoxypropionaldehyde and hydrogen are subjected to a contact reaction on a second catalyst, water is used as a solvent, the reaction product continues to be subjected to a contact reaction with a third catalyst solution, and 1, 2-propylene glycol, 1, 3-propylene glycol and acetic acid are obtained after separation treatment. The method is safer in raw materials, simple in process, easy to operate, diversified in product composition and high in market adaptability.

The application belongs to the technical field of food, and particularly relates to an antioxidant solid beverage and a preparation method thereof. The antioxidant solid beverage is characterized by comprising the following components: polyphenol raw materials, collagen peptide, fructo-oligosaccharide, pyrroloquinoline quinone disodium salt, and fruit and vegetable powder as a flavoring agent added or not added. The addition of fructo-oligosaccharide can improve the preservation rate of polyphenol substances and fully exert the antioxidant effect. The application further provides a preparation method, which can ensure the mixing uniformity of trace, heat-sensitive and unstable raw materials in the solid beverage and effectively protect the activity of effective components in the product.

The invention provides a preparation method and application of a composite material NiSeZn (g-C3N4) / CNFs (carbon nanofibers). The preparation method comprises the following steps: carrying out alkali treatment on the carbon nanofibers, and then carrying out graft modification and freezing denaturation treatment on the carbon nanofibers by using a silane coupling agent; niSeZn (g-C3N4) is grown on the modified carbon nanofibers, and NiSeZn (g-C3N4) / CNFs is prepared through two times of calcination. According to the preparation method of the composite material NiSeZn (g-C3N4) / CNFs, provided by the invention, the comprehensive performance such as electric conductivity, heat conductivity, bending strength and compressive strength of the composite material is enhanced through the processes of grafting modification, freezing denaturation treatment and secondary high-temperature and high-pressure calcination, and the application of the composite material in a composite bipolar plate of a hydrogen fuel cell is facilitated. And in the method, the used raw materials are safe, and the cleaning liquid can be recycled, so that the generation of waste liquid can be reduced, and the problem of environmental harm caused by a soaking mode is avoided.

Disclosed is a composition for preventing autoimmune disease or for preventing and treating hair loss. A functional composition for hair loss according to an embodiment of the present invention is a composition for preventing and treating autoimmune disease or hair loss, the functional composition comprising a functional ingredient for hair loss extracted from a natural substance, wherein the functional ingredient for hair loss comprises, as an active ingredient, any one or more selected from the group consisting of Brevilin A, Arnicolide D, Arnicolide C, and Microhelenin C.

The invention discloses a bacteriostatic finishing agent, a preparation method of dry and comfortable bacteriostatic pure cotton non-woven fabric and a disposable hygienic product. Emulsifying and mixing the prepared antibacterial finishing agent and the water-repellent finishing agent by adding a surfactant; the antibacterial finishing agent is dispersed in the water phase, the water-repellent finishing agent is dispersed in the oil phase, and the pure cotton non-woven fabric is subjected to after-finishing; free active sites react with hydroxyl groups on pure cotton non-woven fibers to occupy hydroxyl active sites in the region, and meanwhile, due to the steric hindrance effect with chitosan and polylysine polymer chains, the situation that the hydrophilic performance is reduced due to spreading of a water-repellent finishing agent in the region is prevented. The antibacterial finishing agent is safe in raw materials, efficient to use, free of irritation and sensitization and stable in antibacterial effect, the antibacterial finishing agent and the water-repellent finishing agent are emulsified and mixed by adding the surfactant, and the steric hindrance effect is constructed; the water-repellent finishing agent is prevented from spreading in the area, and a special after-finishing process is adopted for after-finishing, so that the dryness of the non-woven fabric is improved.

The invention relates to an exosome oral spray and a preparation method thereof, and relates to the technical field of oral sprays.The exosome oral spray is prepared from, by weight, 0.2-0.7 part of human umbilical cord mesenchymal stem cell exosome, 1-5 parts of natural extract, 8-15 parts of moisturizing solubilizer, 0.1-0.5 part of preservative, 0.1-0.5 part of essence and 78-90 parts of deionized water; the natural extract is obtained by performing water extraction on raw materials of clinacanthus nutans and xanthoceras sorbifolia bunge kernels in a weight ratio of (14-20): (5-11). According to the invention, the human umbilical cord mesenchymal stem cell exosome and the natural extract with specific composition are taken as functional components, and the exosome and the natural extract cooperate with each other and act together, so that the repairing effect of the exosome oral spray on skin injury is remarkably improved, the treatment of common oral diseases such as oral ulcer and oral mucositis is facilitated, and the application is wide.

The invention discloses a diisooctyl / isononyl / isodecyl terephthalate plasticizer composition as well as a preparation method and application thereof, the diisooctyl / isononyl / isodecyl terephthalate plasticizer composition is prepared from terephthalic acid, isooctyl alcohol (A), isononyl alcohol (B) and isodecyl alcohol (C) through esterification reaction, and the molar ratio of terephthalic acid to total alcohol is 1: (2-3); the molar ratio of the isooctyl alcohol (A) to the isononyl alcohol (B) to the isodecyl alcohol (C) is (0-3): (0-3): (0-3). The raw materials used in the synthesis process of the diisooctyl / isononyl / isodecyl terephthalate plasticizer composition are safe, the synthesis process is simple, the cost is low, and the diisooctyl / isononyl / isodecyl terephthalate plasticizer composition is suitable for industrial processing production, high in heat resistance and not prone to precipitation.

The utility model discloses a tension compensation device of a grass yarn wrapping machine, the grass yarn wrapping machine comprises a rotating shaft and a yarn cylinder, the upper end and the lower end of the yarn cylinder are respectively provided with an upper clamping ring and a lower clamping ring, the upper end of the upper clamping ring is provided with an upper frustum, the tension compensation device comprises an upper pressing ring, a lower pressing ring and a leaf spring cylinder, the upper pressing ring is in a circular ring shape, and an inner hole is a conical hole; the lower pressing ring is composed of a circular ring with a frustum and a supporting piece connected with the circular ring, the supporting piece is connected with a machine frame of the grass yarn wrapping machine, the upper pressing ring is installed on the circular ring of the lower pressing ring, the lower end of the spring piece barrel is clamped between a conical hole of the upper pressing ring and the frustum of the lower pressing ring, and the lower end of the spring piece barrel is connected with the lower pressing ring. The upper clamping ring is sleeved with the upper pressing ring, the lower pressing ring and the leaf spring barrel, and the upper end of the leaf spring barrel makes contact with the upper frustum of the upper clamping ring or a gap is formed between the upper end of the leaf spring barrel and the upper frustum of the upper clamping ring. According to the utility model, the artificial turf yarns are prevented from being in a free splashing state during high-speed unwinding, so that the tension state of the artificial turf yarns is effectively controlled.

The invention provides a preparation method and application of a phenethyl caffeate photoresponse liposome. According to the preparation method disclosed by the invention, the CAPE or a grafted compound of the CAPE and mercaptocholesterol is respectively embedded into a phospholipid bilayer to obtain the novel photoresponse liposome, and the novel photoresponse liposome can be used for wrapping an active matter, so that photoresponsiveness and efficacy are combined and have a synergistic effect. The photoresponse liposome has high light-controlled release efficiency, high thermal stability and high oxidation resistance, and has good innovation and application prospects in the field of cosmetics.

The present invention belongs to the technical field of medical materials, and relates to a sol-gel preparation method and product of 45S5 bioactive glass. The preparation method comprises the following steps: (1) synthesis of phosphoric acid-ethylene glycol ester; (2) preparation of nitrogen-containing carbon quantum dots; (3) preparation of sol; (4) preparation of aqueous solution; (5) preparation of gel; and (6) heat treatment. The present invention also provides a 45S5 bioactive glass. In the sol-gel preparation method of the present invention, phosphoric acid-ethylene glycol ester is used as the source of P2O5 in the product, which can avoid the problem of difficult control of product phosphorus content and waste of raw materials caused by volatilization when triethyl phosphate is used as a raw material in the prior art. At the same time, nitrogen-containing carbon quantum dots are used, so that the specific surface area of ​​the prepared 45S5 bioactive glass is effectively improved. The present invention has the advantages of safe raw materials, short required gel time, stable oxide components in the product, and high specific surface area of ​​the prepared 45S5 bioactive glass.

The invention provides a method for preparing propylene glycol from vinyl acetate and application of the propylene glycol. Vinyl acetate, synthesis gas and a first catalyst are subjected to a contact reaction in a hydroformylation reaction unit, part of hydroformylation reaction products are cooled and then returned to control the reaction temperature, and crude acetoxypropionaldehyde, the first catalyst and a solvent or a mixture thereof are separated from the other part of the reaction products under reduced pressure for recycling; the crude acetoxypropionaldehyde and hydrogen are subjected to a contact reaction on a second catalyst, a hydrogenation product is cooled, part of the product is recycled as a solvent, the other part of the product is subjected to a contact reaction with a third catalyst, an organic phase and the catalyst obtained after separation are recycled, and an obtained water phase is fed into a refining unit to sequentially separate 1, 2-propylene glycol, 1, 3-propylene glycol and acetic acid products. The method is safer in raw materials, simple in process, easy to operate, diversified in product composition and high in market adaptability.

The invention provides a preparation process and application of novel phosphatidylated carnosic acid, and the preparation process comprises the following steps: mixing 3-5 parts by mass of soybean phospholipid and 1-3 parts by mass of modified soybean phospholipid, melting at low temperature, adding 5-10 parts by mass of carnosic acid, mixing, and curing at low temperature to obtain the novel phosphatidylated carnosic acid. The preparation method of the modified soybean phospholipid comprises the following steps: (1) adding organic acid into soybean concentrated phospholipid serving as a raw material, and uniformly stirring for later use; and (2) continuously adding the material prepared in the step (1) into an absorption tower, intermittently or continuously blowing ozone into the absorption tower at the same time, enabling the material to be in contact with the ozone to carry out oxidation reaction, discharging the material from the absorption tower, and drying at the vacuum degree of 0.095-0.1 Mpa to prepare the modified soybean phospholipid. After the carnosic acid is phosphatized, the stability can be improved, and the bioavailability of the carnosic acid can be enhanced. The application of the compound in the fields of food, food additives, animals, pets, cosmetics or other antioxidation and the like is expanded.

The invention belongs to the technical field of functional foods and health foods, and particularly relates to a composition capable of improving intestinal health, enhancing organism immunity and regulating mood health through an intestine-brain axis and application. The composition is prepared from the following components in parts by weight: 44 to 74 parts of plant extract, 7 to 25.5 parts of inactivated probiotics, 10 to 20 parts of short-chain fatty acid and 22 to 44 parts of prebiotics, the plant extract comprises at least one of an oregano extract, a cinnamon extract, a ginger extract, a turmeric extract and a spearmint extract; the short-chain fatty acid comprises at least one of tributyrin microcapsule powder, sodium butyrate and calcium butyrate. The four components are combined for use in a specific amount ratio range, can form a complementary effect on the basis of respective effects, and comprehensively act on the intestinal tract, the immune system and the intestinal-brain axis to form a collaborative network, so that the intestinal tract health is comprehensively improved, the immunity is enhanced, and the mood health is regulated.

The present invention relates to a preparation method of a dimethicone cream, comprising the following steps: step 1, adding carbomer to purified water, freezing at 20°C, stirring, until carbomer is completely dissolved, and obtaining a carbomer transparent gel; step 2, mixing dimethicone, white vaseline and carbomer transparent gel and stirring evenly to obtain a pre-emulsified gel system; step 3, adding sorbic acid and purified water to stearic acid polyoxyethylene (40) ester, heating to dissolve, and obtaining an aqueous phase; step 4, adding the aqueous phase to the pre-emulsified gel system, stirring evenly to obtain a secondary emulsified paste; step 5, grinding the secondary emulsified paste in a colloid mill to obtain a dimethicone crude cream; step 6, sending the dimethicone crude cream into a homogenizer, high-speed homogenization, and obtaining a dimethicone cream. The product of the present invention is oily, smooth, and has a small particle size; and the product quality is stable.

The invention provides lipidosome with sodium lauroyl lactylate as a substrate and a preparation method of the lipidosome, and belongs to the technical field of cosmetics. The liposome is prepared from the following components in percentage by weight: 5 to 20 percent of sodium lauroyl lactylate, 1 to 10 percent of cholesterol lauroyl glutamate, 15 to 25 percent of polyhydric alcohol, 1 to 5 percent of surfactant, 1 to 5 percent of auxiliary oil phase agent, 1 to 10 percent of active matter and the balance of buffer solution. The sodium lauroyl lactylate is used as a substrate, hydrogen bonds and hydrophobic interaction between proteins are reduced through interaction between lactoyl groups in the structure of the sodium lauroyl lactylate and the proteins in the cuticle of the skin, so that the viscosity of the cuticle is reduced, the permeability of the skin is improved, the sodium lauroyl lactylate is matched with the cholesteryl lauroyl glutamate, the lipid compatibility is improved, and the skin care effect is improved. Active matters in the skin care product can be promoted to more effectively permeate into the deep layer of the skin, so that the permeation efficiency of the active matters is improved.

The invention discloses a biodegradable blocked isocyanate chain extender and a preparation method and application thereof. The chain extender is made of multifunctional isocyanate, a capping agent, a polyol and a catalyst, and can be used in the processing of fully biodegradable materials. The chain extender of the invention is biodegradable, has a fast chain extension reaction speed, and has good environmental compatibility. It contains two carbamate groups with different stabilities, and can form a dynamic micro-crosslinked three-dimensional network in which a chemical crosslinked network and a physical crosslinked network coexist in biodegradable plastics, thereby simultaneously improving the strength and toughness of the material. In addition, the unblocked small molecule capping agent has a synergistic effect with the biodegradable material matrix, has an excellent nitrification inhibition effect in the soil, and can effectively reduce nitrogen loss and improve the utilization rate of nitrogen fertilizer.