The application discloses a kind of preparation and application of
lime key component extract with the effect of relieving
psychological stress, belong to medical technical field.The application uses
Rutaceae citrus plant lime as
raw material, and water phase crude extract is prepared by washing and juicing, and the residue is extracted by ultrasonic-assisted
ethanol to obtain
alcohol phase extract, the two phases are combined and concentrated under reduced pressure, then purified by D101
macroporous resin, to obtain extract rich in active ingredients such as
tangeretin, geniposide B,
neohesperidin, etc.The application has simple process and high extraction efficiency, and the obtained extract is natural in origin and safe in composition.Animal experiments have verified that the extract can significantly improve
anxiety-like behavior caused by stress, and the effect of relieving
psychological stress is better than that of single
hesperidin, and it can also effectively improve abnormal
weight loss caused by stress, regulate the level of
inflammatory factors in the body, and balance psychological relaxation and physiological protection.The application fills the application gap of
lime in the field of
psychological stress relief, and provides a new scheme for developing natural and safe
stress relief products.