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Preparation of Ginkgo Damo injection

A technology of Damo injection and Ginkgo biloba, which is applied in the preparation of Ginkgo Damo injection and the field of small-volume injections. It can solve the problems of high unqualified rate of clarity, strong irritation of the drug solution, and poor quality stability, and achieve inhibition of high aggregation. Sexuality, stable curative effect, and good stability

Active Publication Date: 2010-12-15
通化谷红制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Ginkgo Damole injection (an injection made by mixing Ginkgo biloba extract and dipyridamole) on the domestic market should contain 0.90-1.10 mg of total ginkgo flavonoids per 1 ml, and dipyridamole (C 24 h 40 N 8 o 4 ) should be 0.36-0.44mg) produced by a number of companies, all of which are prepared by traditional techniques. The product quality stability is poor, the liquid is highly irritating, the clarity of the unqualified rate is high, the pH value decreases, and the content decreases. Problems such as deepening of color and unstable curative effect cannot be solved

Method used

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  • Preparation of Ginkgo Damo injection

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A) Preparation of Ginkgo biloba extract: Ginkgo biloba is crushed, 8 times the amount of 60% ethanol is added, refluxed twice at 50° C. for 3.5 hours each time, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure to the volume of the extract 1 / 8 of the concentration, add distilled water 3 times the amount of concentrated solution, add 1% concentrated solution of co-solvent to filter, the filtrate is adsorbed by macroporous resin, and desorbed with 60% ethanol solution, and the desorption solution is added to freshly injected 50% of the prepared amount Water, ultrasonic treatment for 30 minutes, refrigerated at 4°C for 24 hours, and ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 10,000 to obtain the ginkgo leaf extract.

[0027] B) Take fresh water for injection with a preparation amount of 10% at 10°C, adjust the pH value to 1.2, add dipyridamole in the prescription under dark conditions, stir ...

Embodiment 2

[0030] A) Preparation of Ginkgo biloba extract: Ginkgo biloba is crushed, 12 times the amount of 80% ethanol is added, refluxed twice at 45° C. for 2 hours each time, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure to the volume of the extract 1 / 12 of the concentration, add distilled water of 1.5 times the amount of the concentrated solution, add 1.5% of the concentrated solution as a co-solvent to filter, the filtrate is adsorbed by the macroporous resin, and desorbed with 80% ethanol solution, and the desorption solution is added to a fresh injection of 65% of the prepared amount Water, ultrasonic treatment for 25 minutes, refrigerated at 6°C for 36 hours, and ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 10,000 to obtain ginkgo biloba extract.

[0031] B) Take fresh water for injection with a preparation amount of 25% at 25°C, adjust the pH value to 1.5, add dipyridamole in the prescription un...

Embodiment 3

[0034] A) Preparation of Ginkgo biloba extract: Ginkgo biloba is crushed, 15 times the amount of 50% ethanol is added, refluxed twice at 40°C for 2.5 hours each time, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure to the volume of the extract 1 / 6 of the concentrated solution, add 2 times the distilled water of the concentrated solution, add 2.5% of the concentrated solution as a co-solvent to filter, the filtrate is absorbed by the macroporous resin, and desorbed with 70% ethanol solution, and the desorbed solution is added to the fresh injection of 60% of the prepared solution Water, ultrasonic treatment for 20 minutes, refrigerated at 10°C for 12 hours, and ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 10,000 to obtain ginkgo biloba extract.

[0035]B) Take fresh water for injection with a preparation amount of 15% at 30°C, adjust the pH value to 1.4, add dipyridamole in the prescription under...

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Abstract

A gingko-dipyridamole injection for treating cerebral thrombus, cerebrovascular spasm, cerebral insufficiency, ischemic heart disease, ischemic retinosis, etc is prepared from gingko leaves through breaking, reflux extracting in alcohol, concentrating, filtering, resin adsorption, alcohol eluting to obtain liquid extract, mixing with dipyridamole in dark condition, filling N2, pouring in containers, sterilizing, lamp examining, and packing.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparation preparation methods, in particular to a preparation method of Ginkgo-Damole injection, and more specifically to a small-capacity injection with Ginkgo extract and dipyridamole as main components. Background technique [0002] Ginkgo Damole Injection is a water-soluble preparation prepared from Ginkgo biloba extract and dipyridamole. Ginkgo biloba is the dried leaf of Ginkgo biloba plant, which is a traditional Chinese medicinal material for promoting blood circulation and removing blood stasis. It has good pharmacological effects in treating cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, and hyperlipidemia. Ginkgo biloba extract contains effective components such as total flavonoids and total lactones, and total flavonoids are the main active components of Ginkgo biloba extract. The total flavonoids mainly exist in the form of glycosides in Gi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61P7/02A61P9/10A61P27/02A61K31/519
Inventor 张玉梅
Owner 通化谷红制药有限公司
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