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Preparation method of multi-kind micro-element injection

A trace element and injection technology, which is applied in the field of preparation of various trace element injections, can solve the problems of strong irritation, decreased content, poor product stability, etc., and achieves reduction of related substances, reduced irritation, and increased stability. Effect

Inactive Publication Date: 2006-09-13
巴里莫尔制药(通化)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, a variety of trace element injections in the domestic market are prepared by traditional techniques, and the existing products have poor stability, strong irritation, high failure rate of clarity, pH value changes, content decline, color deepening, and curative effect is not good. Stability and other problems can not be solved, the main reason is that there is no equilibrium state between various elements in the preparation process, some redox reactions are not complete, and some by-products are not completely removed.

Method used

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  • Preparation method of multi-kind micro-element injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A) Take fresh water for injection with a preparation amount of 15% at 80°C, cool down to 25°C, add chromium chloride, ferric chloride, zinc chloride, copper chloride, and manganese chloride in the prescription in order, and stir well, Ultrasonic treatment for 15 minutes, shading and sealing, refrigerating at 8°C for 24 hours, ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 100,000, and ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 10,000 to obtain ultrafiltrate I.

[0030] B) Take fresh water for injection with a preparation volume of 10% at 90°C, lower the temperature to 25°C, add sodium molybdate and sodium selenite in the prescription in sequence, stir well, ultrasonicate for 20 minutes, shading and airtight, and refrigerate at 5°C After 24 hours, ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 100,000, and then ultrafiltration with an ultrafiltration membrane...

Embodiment 2

[0035] A) Take fresh water for injection with a preparation amount of 20% at 85°C, cool down to 30°C, add chromium chloride, ferric chloride, zinc chloride, copper chloride, and manganese chloride in the prescription in order, and stir well, Ultrasonic treatment for 20 minutes, shading and sealing, refrigerated at 5°C for 12 hours, ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 100,000, and ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 10,000 to obtain ultrafiltrate I.

[0036]B) Take fresh water for injection with a preparation volume of 15% at 90°C, lower the temperature to 30°C, add sodium molybdate and sodium selenite in the prescription in sequence, stir well, ultrasonicate for 20 minutes, shading and airtight, and refrigerate at 10°C After 24 hours, ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 100,000, and then ultrafiltration with an ultrafiltration membrane ...

Embodiment 3

[0041] A) Take fresh water for injection with a preparation amount of 25% at 90°C, cool down to 20°C, add chromium chloride, ferric chloride, zinc chloride, copper chloride, and manganese chloride in the prescription in order, and stir well, Ultrasonic treatment for 25 minutes, shading and sealing, refrigerating at 7°C for 36 hours, ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 100,000, and ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 10,000 to obtain ultrafiltrate I.

[0042] B) Take fresh water for injection with a preparation amount of 5% at 85°C, cool down to 20°C, add sodium molybdate and sodium selenite in the prescription in sequence, stir well, ultrasonicate for 15 minutes, shading and airtight, and refrigerate at 5°C After 12 hours, ultrafiltration with an ultrafiltration membrane with a molecular weight cut-off of 100,000, and then ultrafiltration with an ultrafiltration membrane with a molec...

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Abstract

An injection of trace elements for providing external nutrients is prepared through depositing in water, cold storage, ultrasonic treating, ultrafiltration, adding filtered sorbitol in dark condition and N2 atmosphere, pouring in containers, sterilizing and lamp examining.

Description

technical field [0001] The present invention relates to a kind of preparation method of various microelement injections, specifically, to a kind of preparation method that is made of chromium chloride, ferric chloride, zinc chloride, cupric chloride, manganese chloride, sodium molybdate, selenous acid The pharmaceutical composition composed of sodium, sodium fluoride, and potassium iodide is processed by water sedimentation, refrigeration, ultrasound, and ultrafiltration technology in a specific order, and then prepared with sorbitol ultrafiltrate under the condition of avoiding light and filling with nitrogen, and pouring After being sterilized, inspected by light and packaged, it is made into finished products of small-capacity injections of various trace elements, which belongs to the field of chemical preparations. This product is a part of intravenous nutrition, which has the pharmacological effects of promoting human growth and development, enhancing body immunity, anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/34A61K9/08A61P3/02A61K33/24A61K33/26A61K33/30A61K33/32
Inventor 郭智华
Owner 巴里莫尔制药(通化)有限公司
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