The invention discloses a pidotimod effervescent tablet and a preparation method thereof. The pidotimod effervescent tablet comprises the following components in parts by weight: 300 to 500 parts of pidotimod, 100 to 400 parts of filling agent, 100 to 200 parts of effervescent disintegrating agent, 5 to 15 parts of essence, 6 to 10 parts of lubricant, and a proper amount of adhesive. The preparation method comprises the following steps: weighing pidotimod and a filling agent according to abovementioned formula, sieving pidotimod and the filling agent by an 80-mesh sieve, evenly mixing, adding sodium chloride into a PVPK30 water solution (8%), then adding the solution into powder to prepare a soft material, sieving the soft material by a 24-mesh sieve, preparing granules, paving the granules on a disc, drying the granules in a drying box at a temperature of 60 DEG C, taking out the granules until the water content of the granules is qualified, adding an effervescent disintegrating agent, a flavoring agent, and a lubricant, evenly mixing, measuring the intermediate content, pressing the mixture to obtain tablets, and finally carrying out detection and packaging. The provided pidotimod effervescent tablet and the preparation method have the advantages that the concentration of pidotimod in the blood of human body is high, the bioavailability of pidotimod is increased, at the same time, the stability of the pidotimod effervescent tablet is very high, and the pidotimod effervescent tablet can be stored stably.