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Pidotimod capsule preparation and preparation thereof

A pidotimod and capsule technology, applied in the field of chemical pharmacy, can solve the problem of no pidotimod capsule preparation, etc., and achieve the effects of improving drug stability, slowing down decomposition and fast absorption

Inactive Publication Date: 2008-08-06
沈阳双鼎制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new type of medication called capsuledidomide solves problems with older methods such as bitters or smells that may be caused when administering it through injection into humans. It also prevents water from evaporating too much while still being effective at treating certain medical conditions like rheumatoid arthritis.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the safety and efficacy of antihypophilins such as chlorpromillamines when administering them alone or together with other medications without causing side effects associated with reduced immunosuppression capacity.

Method used

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  • Pidotimod capsule preparation and preparation thereof
  • Pidotimod capsule preparation and preparation thereof
  • Pidotimod capsule preparation and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Based on 1000 pidotimod capsules, crush pidotimod, starch, and low-substituted hydroxypropyl cellulose through a 100-mesh sieve, weigh 400 g of pidotimod, 3 g of starch, and 7 g of low-substituted hydroxypropyl cellulose, Mix evenly according to the principle of equal increase, add an appropriate amount of soft material made of starch slurry, use a 60-mesh sieve to make granules, dry at 60°C for 2-3 hours, granulate, and pack into capsules. Each capsule contains 400mg of pidotimod.

Embodiment 2

[0029] Based on 1000 pidotimod capsules, crush pidotimod, starch and sodium carboxymethyl starch through a 100-mesh sieve, weigh 200g of pidotimod, 82g of starch, and 15g of sodium carboxymethyl starch, and press etc. The principle of increasing the amount is to mix evenly, add an appropriate amount of sodium carboxymethyl starch solution to make soft materials, use a 24-mesh sieve to make granules, dry at 60°C for 4 hours, pass through a 24-mesh sieve for granulation, add 3g of magnesium stearate, and mix evenly. Packed in capsules, each capsule contains 200mg of pidotimod.

Embodiment 3

[0031] Based on 1000 pidotimod capsules, crush pidotimod, starch, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose through a 100-mesh sieve, weigh 200 g of pidotimod, 52 g of starch, and microcrystalline cellulose 30g of cellulose, 15g of low-substituted hydroxypropyl cellulose, mix evenly according to the principle of equal increase, add appropriate amount of starch slurry to make soft material, sieve with 24 mesh to make granules, dry at 60°C for 2 to 3 hours, and pass through a 24 mesh sieve granules, add 3g of magnesium stearate, mix evenly, pack into capsules, each capsule contains 200mg of pidotimod.

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Abstract

The invention provides Pidotimod capsule preparation comprising major medical component Pidotimod and pharmaceutically acceptable medical auxiliary material, which is capsule. Chemical name of the major medical component Pidotimod is: (R)-3-((S)- (5-oxo-2-pyrrolidyl)-carbonyl)-tetrahydro-thiazole-4-carboxylic acid. The capsule overcomes the disadvantages of other dosage forms of the Pidotimod, and has the functions of photophobism and dampproof ability; the capsule can also conceal poor smell of the medicine, prevent and slow down decomposition and improve stability of the medicine so as to ensure that curative effects of the medicine can be better displayed; moreover, the dosage of the capsule can be easily disintegrated, with rapid absorption, high bioavailability and convenient clinical application compared with dosage forms such as tablet preparation, etc.

Description

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Claims

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Application Information

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Owner 沈阳双鼎制药有限公司
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