Use of pidotimod to treat psoriasis

A technology for pidotimod and psoriasis, applied in the field of application of pidotimod in the treatment of psoriasis, which can solve the unsatisfactory medical needs of curative effect and prevention of recurrence, the duration is not very long, and long-term and durable treatment is limited, etc. question

Active Publication Date: 2015-08-26
POLICHEM SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Regardless of the treatment, the effect is only clinical and does not last very long
Moreover, strong toxicity limits long-lasting treatment
Therefore, there remains an unsatisfactory medical need in terms of efficacy and prevention of relapse

Method used

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  • Use of pidotimod to treat psoriasis
  • Use of pidotimod to treat psoriasis
  • Use of pidotimod to treat psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An oil-in-water cream was prepared with the following w / w% components:

[0026]

[0027]

[0028] *Tromethamine

[0029] preparation

[0030] In the main container, dissolve ingredients 1, 2, 3, 4, 5 in some of the water. Add xanthan gum and disperse completely until homogenized. Separately dissolve component 7 in some of the water and add it to the main vessel with stirring. Heat the phase at 70-75°C. Components 8, 9, 10, 11, 12 were mixed in a separate vessel and heated at 70-75°C with stirring. The two phases heated at the same temperature were combined and homogenized for about 10 minutes. Cool to 40°C and add components 13 and 14 sequentially, homogenizing after each addition.

[0031] Cool to room temperature with moderate stirring.

Embodiment 2

[0033] A topical solution was prepared with the following w / w% components:

[0034]

[0035] preparation

[0036] Dissolve components 1, 2, 3, 4, 6 in water. Add component 7 and mix until a clear solution is obtained.

Embodiment 3

[0038] A body and scalp cleansing formulation was prepared with the following w / w% components:

[0039]

[0040] preparation

[0041] Mix Surfactant Mix 5 in the main container. Component 8 was added and dissolved to a clear solution. Add component 9 and mix until homogenized. Separately, in some of the water, dissolve ingredients 1, 2, 4, 6 and add them to the main container with stirring. Component 7 was added last to adjust the viscosity. Mix until clear solution.

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PUM

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Abstract

The present invention is directed to the use of pidotimod, or a physiologically acceptable salt thereof, to treat psoriasis. For the treatment of the present invention, pidotimod, or a physiologically acceptable salt thereof, may be administered either systemically or topically.

Description

technical field [0001] The present invention relates to the use of pidotimod or its physiologically acceptable salt for treating psoriasis. Background technique [0002] Psoriasis is a common chronic multisystem disease with distinct skin and joint clinical manifestations, affecting about 2% of the population. The main clinical manifestation of psoriasis is a chronic lesion of the skin. It is characterized by lesions, scaling and red patches, which may be painful or often severely itchy, and which may cause significant quality of life problems. Psoriasis is a chronic disease with waxing and waning cycles over a patient's lifetime, which usually changes with initial treatment and cessation of treatment, and rarely resolves spontaneously. More severe distributions of psoriasis include psoriatic arthritis, nail psoriasis, and enthesitis, an autoimmune disorder associated with nails and joints involved in psoriatic disease. [0003] Psoriasis is a complex genetic disorder of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61K38/05A61P17/06
CPCA61K38/05A61K31/427A61P17/00A61P17/06A61P19/02A61P3/02A61P37/06A61P43/00A61K45/06
Inventor M·卡塞里尼F·美拉德
Owner POLICHEM SA
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