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Oral liquid preparation capable of enhancing immunity

A liquid preparation and immune-enhancing technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and dispersion delivery, etc. It can solve product instability, increase the process, and be unfavorable for diabetics and sugar patients. To avoid drug denaturation, enhance compliance, and taste suitable

Inactive Publication Date: 2017-01-25
FRONT PHARM PLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the flavoring agent contained in the above-mentioned pidotimod oral solution preparation contains sugars, which is unfavorable for diabetics and other patients who should not take sugar.
At the same time, sodium hydroxide is used to adjust the pH value, which increases the process and also brings some product instability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] By weight, each 700 mL oral solution contains the following ingredients: 20 grams of pidotimod, 0.56 grams of sodium chloride, 0.30 grams of disodium edetate, 19.35 grams of ammonium tromethamine; sodium methylparaben 1.00g, Propylparaben Sodium 0.15g, Acesulfame K 0.4g, 2,4-Hexadienol 150g, Raspberry Natural Flavor 2.0g, Blueberry Anthocyanin 1.0g, Carmine 50mg, the rest is water .

[0024] Add 150 grams of 2,4-hexadienol, 0.4 grams of acesulfame potassium, 2.0 grams of raspberry natural essence, 1.00 grams of sodium methylparaben and 0.15 grams of sodium propylparaben into the configuration container, add an appropriate amount of purified Dissolve in water (pH6.0±1), add 19.35 grams of tromethamine, 0.56 grams of sodium chloride, 0.3 grams of disodium edetate, add water to near scale, add 20 grams of pidotimod, 2.0 grams of blueberry anthocyanin gram, carmine 50 mg, and finally add water to the full amount, dissolve until clear, measure the pH value, and the range ca...

Embodiment 2

[0026] By weight, each 700 mL oral solution contains the following ingredients: 40 grams of pidotimod, 0.56 grams of sodium chloride, 0.35 grams of disodium edetate, 19.3 grams of ammonium tromethamine; sodium methylparaben 1.03 grams, 0.16 grams of propylparaben sodium, 0.5 grams of acesulfame potassium, 175 grams of 2,4-hexadienol, 2.1 grams of raspberry natural essence, 1.0 grams of blueberry anthocyanin, 50 mg of carmine, and the rest is water .

[0027] Add 175 grams of 2,4-hexadienol, 0.5 grams of acesulfame potassium, 2.1 grams of raspberry natural essence, 1.03 grams of sodium methylparaben and 0.16 grams of sodium propylparaben into the configuration container, add an appropriate amount of purified Dissolve in water (pH 6.0±1), add 19.3 grams of tromethamine, 0.56 grams of sodium chloride, 0.35 grams of disodium edetate, add water to near scale, add 40 grams of pidotimod, 1.0 grams of blueberry anthocyanin grams, 50 mg of carmine, and finally add water to the full am...

Embodiment 3

[0029] By weight, each 700 mL oral solution contains the following ingredients: 60 grams of pidotimod, 0.56 grams of sodium chloride, 0.40 grams of disodium edetate, 23.3 grams of ammonium tromethamine; sodium methylparaben 1.03 grams, 0.1 grams of p-hydroxyanisole, 0.5 grams of acesulfame potassium, 185 grams of 2,4-hexadienol, 2.1 grams of raspberry natural essence, 1.0 grams of blueberry anthocyanin, 50 mg of carmine, and the rest is water.

[0030] Add 185 grams of 2,4-hexadienol, 0.5 grams of acesulfame potassium, 2.1 grams of raspberry natural essence, 1.03 grams of sodium methylparaben and 0.1 grams of p-hydroxyanisole into the configuration container, and add an appropriate amount of purified water ( pH 6.0±1), add 19.3 grams of tromethamine, 0.56 grams of sodium chloride, 0.4 grams of edetate disodium and 40 grams of pidotimod, add water to near scale, dissolve and clarify, and then add blueberry anthocyanin 1.0 g, 50 mg of carmine, dissolve, add water to a sufficient...

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PUM

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Abstract

The invention discloses an oral liquid preparation capable of enhancing immunity, which can stimulate human immunoreaction, obviously reduce the emergent onset times and degree of infectious diseases, and shorten the development and progression courses of diseases. The oral liquid preparation contains components of pidotimod, chemical stabilizers, flavoring agents, and the like. The stability and flavor of the oral liquid preparation can be obviously improved through the quantitative proportion and synergic action by adopting water as a solvent, the bioavailability of the oral liquid preparation is obviously higher than that of a solid preparation, the dispersion degree is large, and the oral liquid preparation is more suitable for carrying and oral administration of old people or children.

Description

technical field [0001] The invention relates to an oral liquid preparation for enhancing immunity and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Immunomodulation refers to the interaction between immune cells and immune molecules in the immune system, as well as with other systems such as the neuroendocrine system, so that the immune response can be maintained at the most appropriate level in the most appropriate form. The body recognizes and eliminates antigenic foreign bodies, maintains its own physiological dynamic balance and relative stability, and the immune regulation is realized by the immune system (Immune system); the immune regulation response in the human body includes specific immune response and non-specific immune response, directly affect human health. Pidotimod is a safe and effective immune function enhancer, a fully synthetic immunostimulator regulator, its structure is similar to dipeptide, oral and intra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K38/05A61K31/427A61P37/04
CPCA61K9/0095A61K9/08A61K31/427A61K38/05A61K47/46
Inventor 戴五好戴小华张强
Owner FRONT PHARM PLC
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