112results about How to "Strong compliance" patented technology

The invention discloses a tracing anti-fake market interaction integration system and method. The tracing anti-fake market interaction integration system and the tracing anti-fake market interaction integration method break through limitation on the cover degree of an existing tracing anti-fake system, achieve the purpose that one product is provided with one code, and put anti-fake into practice for every consumer. The anti-fake method that one product is provided with one code is adopted in the whole process of product delivery and sale. The method includes the steps of correspondence of identification codes to goods and correspondence of the identification codes to spraying in the process of anti-fake code generation and subsystem generation, then based on identification code scanning and network transmission, the most detailed anti-fake is achieved under the condition of little expenditure, and anti-fake and authentication effort for each product is guaranteed.

A traditional Chinese medicinal preparation for treating middle and old aged male diseases caused by kidney vacuity and a preparation method thereof. The traditional Chinese medicinal preparation is made from the following raw materials of: by weight, 10-40 parts of jujube, 10-40 parts of sharpleaf galangal fruit, 10-40 parts of raspberry, 10-40 parts of wolfberry, 10-40 parts of Chinese yam, 10-40 parts of polygonatum rhizome, 5-40 parts of Gorgon fruit and 5-40 parts of orange peel. The preparation provided by the invention has functions of nourishing liver and kidney, arresting polyuria, improving yang deficiency, nourishing liver and kidney yin, adjusting insufficiency of body fluid, nourishing and invigorating spleen, enriching blood, reinforcing the kidney and controlling noctural emission, invigorating spleen and stopping diarrhea, nourishing yin and yang and reinforcing liver and kidney, and has a good curative effect of treating middle and old aged male common symptoms such as body tiredness and hypodynamia, overfrequent nocturia, impotence, premature ejaculation and the like. The raw medicines of the preparation provided by the invention are all vegetation edible and medicinal materials with no toxic and side effect. The preparation provided by the invention has advantages of good taste and strong patient compliance, and is applicable to be taken for a long time.

The invention relates to a triad integration freckle-removing functional nano cream for skin external use and a method for preparing the same. The three types (night use type, daytime use type and auxiliary type) freckle-removing nano creams improve and optimize a novel international passive target transdermal drug delivery system (TDDS) as a carrier, and organically combine and solubilize freckle-removing functional components with different biological efficacies, action ways and physical and chemical properties to form a good mutual aid synergic function system which has remarkable effect of controlling and relieving colored patches (such as chloasma, inflammatory pigmentation, sunburn, and the like) caused by abnormal facial metabolism of pigment. The product has the advantages of tiny particle sizes of spherical particles, obvious passive target function, excellent adaptability, homodromous property, fluidity and dispersion, strong penetrability, even texture, subtleness, lubricity and luster, is simple and convenient to use, and is comfortable without pungency and side effects; besides, the appearance is light yellow with slight opalescence, is glittering and translucent, clear and transparent, sticky but not viscous, thick but not dense, and oily but not greasy, has good stability, excellent curative effect, short industrialization cycle and high production efficiency, saves time, materials and energy sources, dose not need special devices and heat energy, and is easy for popularization and application.

The invention belongs to the technical field of natural high polymer materials, and particularly relates to a photoresponsive reversible chitosan hydrogel and a preparation method thereof. The preparation method comprises the following steps: by using biocompatible natural high polymer chitosan as an initial material, carrying out chemical modification to respectively introduce carboxymethyl group and coumarin group to the 6-O position and 2-N position, thereby obtaining water-soluble photoresponsive reversible chitosan; and carrying out specific-wavelength ultraviolet irradiation on the photoresponsive reversible chitosan water solution with certain concentration to obtain the chitosan hydrogel. The hydrogel can be converted into sol under certain-wavelength ultraviolet irradiation. The photoresponsive reversible chitosan gel-sol conversion can be implemented by pure controllable ultraviolet irradiation, thereby avoiding using the biologically toxic chemical reagents, enhancing the biocompatibility and use compliance of the chitosan hydrogel, and making the clinical application of the chitosan hydrogel possible. The invention provides a new way for clinical application of the chitosan hydrogel.

The invention relates to the new dosage form of zanamivir, which is a nasal in-situ gel with phase transformation property and preparation methods, the invention is made of the original drug of zanamivir, hydrophilic gel materials which are sensitive to environments and assistant materials which can be accepted in pharmacy, after being absorbed by nasal mucosa, the invention can have systemic functions and improve the partial concentration of drugs in respiratory tracts, when room temperature is about 20 DEG C and the invention is in storing state, the invention is in the state of liquid, while after being put into the physiological conditions of nasal cavities, the invention can be quickly formed into gel on the surface of nasal mucosa, so that the detained time of drugs can be prolonged, biological availability can be improved and the compliance of patients can be perfected, and the viscosity of the invention is proper, after being formed into gel, the invention can be detained on the surface of the nasal cavity for a rather long time, which has no nasal ciliary toxicity.

The invention discloses a manufacturing method of a self-adhesive elastic bandage and the self-adhesive elastic bandage. The method comprises the following steps of: sizing, i.e., sizing a non-woven fabric base material, wherein the pulp for the sizing treatment comprises an adhesive agent, a penetrating agent and a solvent; drying, i.e., drying the sized non-woven fabric base material; and coiling, i.e., coiling the dried non-woven fabric base material to obtain the self-adhesive elastic bandage. Through sizing and coiling of the non-woven fabric base material, the elastic and self-adhesive non-woven fabric bandage is obtained; the production process and equipment structure are simple; and the material cost and the process cost are reduced.

The invention discloses a super compliable recyclable film-covered subsection support which comprises support cup rim portions at the two ends and a support body. The support body is connected with the support cup rim portions at the two ends and is composed of two or more subsection portions. The inner diameter of each cup rim portion is larger than that of each subsection portion. A layer of independent outer sleeving film is arranged on the exterior of the support body in a nested mode, and a mutual motion gap exists between the subsection portions and the outer sleeving film. The subsection portions are connected through an operation line. The invention further discloses a manufacturing method of the super compliable recyclable film-covered subsection support. The manufacturing method comprises the steps that the cup rim portions at the two ends of the support body are embedded into the corresponding positions of the outer sleeving film; a high temperature vulcanization way is adopted to fix the outer sleeving film and the cup rim portions at the two ends of the support body; the connected subsection portions are placed into the outer sleeving film; the operation line is adopted for connecting the subsection portions with the cup rim portions at the two ends of the support body.

The invention provides a traditional Chinese medicine preparation for treating hypertension and hyperlipidemia, and its preparation method, and the traditional Chinese medicine preparation is used for solving the problems of hyperlipidemia and hypertension caused by the factors of diet, emotion and physique. The traditional Chinese medicine preparation comprises the following bulk drugs by weight part: 10-40 parts of rhizoma polygonati, 10-40 parts of rhizoma polygonati officinalis, 10-40 parts of cassia seed, 10-40 parts of kudzu root, 10-40 parts of mulberry leaf, 5-40 parts of haw, 5-40 parts of orange peel and 10-50 parts of ginger. The dosage forms of the invention could be oral thick paste, tea bag, brewing particles and the like. The traditional Chinese medicine preparation is capable of nourishing liver and kidney, increasing the qi-blood driving force of human body, and reducing the blood pressure and blood fat. The bulk drugs of the preparation are edible and medicinal plant medicinal materials without any toxic and side effect which are publicized by Ministry of Public Health, The bulk drugs can not mutually generate toxic intermedium. The traditional Chinese medicine preparation has good mouthfeel and strong compliance of patients, and is suitable for long-term administration.

The present invention relates to dry cefadroxil suspension and its preparation process, belongs to the field of medicine technology, and is for raising the water solubility and bioavailability of cefadroxil. The dry cefadroxil suspension consists of cefadroxil and supplementary material comprising including agent, water soluble stuffing, distintegrating agent, suspension assistant and adhesive. The dry cefadroxil suspension has the features of high medicine solubility, high medicine bioavailability, high chemical stability, good taste, convenient taking, high patient's compliance, full absorption in gastrointestinal tract, less irritation to gastrointestinal tract of medicine, etc.

The invention relates to a pregabalin oral solution and a preparation method thereof. The oral liquid preparation is prepared from pregabalin, preservative, a buffering agent, corrigent and other component. Water is adopted as a solvent, by means of quantitative matching and synergy of all the components, the oral liquid preparation has good stability, the taste is well improved, the life qualityand the drug use compliance of patients are also effectively improved, the bioavailability of the oral liquid preparation is obviously higher than that of solid preparations, and the oral solution ismore suitable for being drunk by old people or children.

The invention discloses a traditional Chinese medicinal preparation for treating deficiency cold and ache of stomach and a preparation method thereof, which are used for solving the discomfort of the stomach part. The traditional Chinese medicinal preparation is prepared from the following raw materials in part by weight: 10-40 parts of small jujube, 10-50 parts of ginger, 5-30 parts of orange peel, 5-30 parts of Chinese cinnamon and 5-30 parts of nutmeg. The traditional Chinese medicinal preparation can be prepared into soft extract, teabag, brewing granules and other forms. The traditional Chinese medicinal preparation disclosed by the invention has the functions of warming the middle-burner and invigorating the spleen, regulating stomach-qi and alleviating pain, regulating vital energy and helping digestion and can be taken for a long time. The pharmaceutical drugs of the traditional Chinese medicinal preparation disclosed by the invention are pharmaceutical and food dual-purpose plane medicinal materials disclosed by Ministry of Health and have no toxic or side effects or toxic intermediates among the medicinal materials; and the traditional Chinese medicinal preparation has favorable mouth feeling and strong patient compliance and is suitable for being taken for a long term.

The invention discloses a docusate sodium soft capsule which comprises a soft capsule rubber skin and docusate sodium solution packaged in the soft capsule shell. The docusate sodium soft capsule is characterized in that the docusate sodium solution consists of the following components in percentage by weight: 10% to 50% of docusate sodium, 35% to 90% of polyethylene glycol and 0% to 15% of polyhydric alcohol; the soft capsule shell comprises a red shell and a white shell; the red rubber skin consists of the following components in percentage by weight: 45% to 80% of gelatin, 10% to 40% of plasticizer, 0.01% to 0.4% of colorant I and 5% to 15% of water; and the white shell consists of the following components in percentage by weight: 45% to 80% of gelatin, 10% to 40% of plasticizer, 0.1% to 4.0% of additive and 5% to 15% of water. The invention aims to overcome the defects in the prior art and provide the docusate sodium soft capsule which comprises simple components and has strong adaptability and high response speed.

The invention discloses a method for preparing a medical bamboo fiber surgical dressing. The method comprises the following steps of: firstly taking medical bamboo fibers, and then manufacturing the surgical dressing by medical bamboo fiber non-woven cloth by a bamboo fiber acupuncturing method. The medical bamboo fiber surgical dressing prepared by the method has the characteristics of coolness and wet absorption and is lower in cost; and the using amount of natural cottons is reduced.

The invention provides a water-soluble cyclodextrin derivative clathrate of fluorouracil, and an in-situ gel film agent containing the clathrate and having biological adhesion and a preparation method thereof. According to the invention, cyclodextrin derivative-hydroxypropyl-beta-cyclodextrin is used to include fluorouracil hardly soluble in water so as to allow the solubility of fluorouracil in water to be improved and fluorouracil to have a slow release effect, so the in-situ gel film agent is prepared; the in-situ gel film agent is a novel cavity drug delivery preparation and comprises the hydroxypropyl-beta-cyclodextrin clathrate of fluorouracil, a temperature-sensitive gel skeletal material and a biologically adhesive material. The preparation is a freely flowable solution before usage, rapidly forms a gel film on the surface of a cavity, has a great drug release area, good biological compatibility and good gel strength and biological adhesion, is capable of firmly adhering on the mucous membrane of the cavity, prolongs action time, realizes uniform drug distribution, is beneficial for absorption of the drug and diffusion of the drug to peripheral tissue and improves bioavailability and treatment effects of the drug.

The invention discloses a silk bulking method and belongs to the technical field of silk bulking. The silk bulking method comprises the steps of primary rinse, permeation, secondary rinse, balancing, drying and the like. After being bulked through the method, silk has high smoothness and color intensity. Through the method, operation is easy, production cost is low, and application and popularization are facilitated.

The invention belongs to the field of medicinal preparations, and relates to a brain-targeting delivery system. The system comprises a mediating molecule, a vector and a medicament, wherein the mediating molecule is a benzamide analog, the vector is a polycation macromolecule, and the mediating molecule and the vector are combined by a covalence mode; and the medicament is carried through an entrapping or adsorption mode. In the system, in-vivo and in-vitro brain-targeting is characterized through a tracer technique to prompt that the delivery system can span a blood brain barrier, and a genemedicament and a diagnosis medicament are delivered into a brain, so the system can be used for brain disease diagnosis and treatment. The system can avoid potential risks of an enteroinvasive administration mode and a complicated administration process, and has the advantages of large administration quantity, simple administration mode and the like; and the brain-targeting mediated molecule has the advantages of small molecular weight, low price and availability and industrialization convenience.

A topical drug for treating tympanitis and its producing method belong to medicine technical field, which is used for treating the simple chronic suppurative otitis media with a project that: having the furazolidone 1.8-2.2, vitamin E 0.9-1.1, benne oil 25-65 as material, preparing, milling, mixing, bottling, then getting the topical drug liquid. The invention collects the treatment advantages of the chinese and foreign medicine to the local fester induced by bacillosis, selects the furazolidone, benne oil, vitamin E in proportion to produce topical drug for treating tympanitis, preferred chronic suppurative otitis media. Clinic application indicates that the drug is used for treating simple chronic suppurative otitis media and taking one time a day and working three day in a treatment period. It could properly prolong the treatment time with 100% efficiency to the patent with a long course of disease and a severe symptom. The invention also has a simple medication, a low toxic side effect, a low price, a strong patent compliance and etc.

The invention discloses a composition and a soft capsule for treating cold for night use. The composition comprises acetaminophen, dextromethorphan hydrobromide, succinic acid doxylamine, polyethylene glycol, polyhydric alcohols and povidone; the soft capsule comprises a soft capsule shell and content in the soft capsule shell, wherein the content comprises acetaminophen, dextromethorphan hydrobromide, succinic acid doxylamine, polyethylene glycol, polyhydric alcohols and povidone, and the soft capsule shell comprises the following components: gelatin, plasticizer, purified water and colorant. Aiming at overcoming the defects of the prior art, the invention provides the composition for treating cold for night use, and the composition has simple components and is stable and effective. The invention also aims at providing the soft capsule comprising the composition, and the soft capsule is applicable to relieving cold symptoms such as headache, fever, cough, rhinobyon, rhinorrhea, irritability, and the like.

The invention discloses a preparation method for a daytime-taken softgel for treating a cold. The preparation method comprises the following steps: A, preparation of a gelatin liquor: dissolving plasticizer in water, adding into a gelatin melting tank, adding gelatin, stirring to dissolve, adding coloring agent into water, stirring uniformly to obtain a pigment solution, adding the pigment solution into an obtained gelatin solution, stirring and vacuumizing to exhaust air bubbles, so as to obtain the gelatin liquor; B, preparation of contents: adding mixed polyethylene glycol and polyhydric alcohol into polyvidone, stirring to dissolve, adding acetaminophen, stirring to obtain a suspension, adding into a proportioning tank, vacuumizing, filling with inert gas, heating to dissolve, cooling, adding dextromethorphan hydrobromide and phenylephrine hydrochloride, vacuumizing, and keeping the temperature to dissolve, so as to obtain a content solution; C preparation of the softgel: adding the gelatin liquor and the content solution into a pelleting machine respectively, pelleting, drying, pellet plastering and packaging. The invention aims to provide the preparation method for the daytime-taken softgel which is used for treating the cold, and is simple in process, convenient to manufacture and good in product stability.

The invention discloses a novel silk swelling agent, and a preparation method thereof, and belongs to the technical field of swelling agent processing. The novel silk swelling agent comprises, by weight, an unwinding agent and a softener; the unwinding agent comprises Na2SiO3 and deionized water; the softener comprises an ester-based quaternary ammonium salt, silicane-modified polyurethane, polyether modified silicane, sodium lignin sulfonate, sodium alkyl benzene sulfonate, starch grafted sodium acrylate, sodium polyacrylate, sodium N-lauroylglutamate, calcium lignosulphonate, citronellal, malic acid, carrageenan, locust bean gum, triadimefon, and deionized water; and the novel silk swelling agent is prepared via following steps: dissolving of the ester-based quaternary ammonium salt, microwave reaction, defoaming, pH value adjusting, preparing of the unwinding agent, and mixing. After application of the novel silk swelling agent, silk possesses excellent softness and colour intensity; the preparation method is simple; and preparation cost is low.

The invention belongs to the field of traditional Chinese medicine healthcare, and particularly relates to a composition with effects of reducing blood pressure, blood fat and blood glucose and use of the composition. The composition is prepared from prepared rhizoma polygonati, dogbane leaves and herb of gynostemma pentaphylla and has the effects of nourishing Yin and kidney, calming liver and suppressing Yang, and invigorating blood and expelling turbid pathogens, and can be used to reduce the blood pressure, the blood fat and the blood glucose. By virtue of pharmacological study and clinical application verification, the composition can be used for preventing and treating high blood pressure, high blood fat and type-II diabetes, and has the advantages of definite curative effect, low cost, no toxic and side effect, convenience in taking, excellent taste, good patient-based compliance and the like.

The invention discloses a method for puffing refined silk, and belongs to the technical field of silk puffing. The method for puffing the refined silk includes the steps of first-time rinsing, permeating, second-time rinsing, balancing, drying and the like. The silk puffed with the method has the high flexible degree and the high color intensity; the method is advanced in technological process, easy to operate and low in production cost, and application and popularization are facilitated.

The invention relates to the technical field of biological medicine, and specifically discloses an animal model construction method for the study of spleen deficiency and dampness syndrome. The animalmodel construction method comprises two steps that 1, a male rat is selected and fed with high-fat feed, the relative humidity is 53+ / -3%, a dark and quiet environment is maintained, the deep color and light color of the back face of the tongue of the rat are regularly subjected to recording, tongue picture capture, comparative analysis and quantitative grading, physiological and biochemical indexes such as intestinal florae, tryptophan and metabolites of the intestinal florae and tryptophan are measured regularly, physical signs such as hair color, urine and excrement and mental conditions of the rat are recorded regularly, and the construction of the rat model in the depression and damp-heat syndrome stage is completed until 4-6 weeks; 2, the rat in the depression and damp-heat syndromestage continues to be fed with the high-fat feed, the relative humidity is increased to 90+ / -3%, the indexes continue to be detected and observed until 8-10 weeks, and the construction of the rat model in the spleen deficiency and stasis syndrome stage is completed. The rat model construction has the advantages that the model construction method is simple, easy to operate and promote, and close to clinic.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating arthralgia as well as a preparation method and an application method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: ephedra, angelica sinensis, monkshood, phryma leptostachya, rhizoma cibotii, taxillus sutchuenensis, herba sarcandrae, Chinese starjasmine stem, carthamus tinctorius, rhizoma zingiberis, cassia twig, cyathula officinalis, caulis spatholobi, eucommia ulmoides, magnolia officinalis, radix angelicae, homalomena occulta, herba schizonepetae, saposhnicovia divaricata, pawpaw, moxa, incised notopterygium, angelica pubescens, curculigo orchioides, epimedium, lilac daphne, ligusticum sinense, ligusticum wallichii and astragalus membranaceus. The traditional Chinese medicine composition is prepared into a decoction to soak an affected part or prepared into powder to be used in a hot dressing manner; the traditional Chinese medicine composition can effectively eliminate various pathogeny causing arthralgia, is long-lasting in curative effect, adopts external fixation and cooperates with a thermal therapy, is simple and convenient to use, high in compliance and suitable for long-time use, and avoids the defects that the traditional chemical drugs are great in toxic and side effects, and poor in compliance.

A particle of bicarnesine with low hydroscopicity and agreeable taste is prepared from bicarnesine, filler, adhesive, wetting agent and flavouring proportionally. Its preparing process is also disclosed.

The invention discloses a nanometer diffuse reflection coating which is prepared by the following components in percentage by weight: 35-50% of suspending polytetrafluoroethylene resin, 40-60% of titanium dioxide, 1-10% of accessory ingredient and 1-5% of C60 polymer nanomaterial, wherein the C60 polymer nanomaterial can weaken the dust adsorption capability of a coating surface and can enhance diffuse reflection effect; the suspending polytetrafluoroethylene resin resists the temperature of 180-250 DEG C, thus the suspending polytetrafluoroethylene resin can normally work, has no phenomena of yellowing, ageing and cracking and has strong conforming capability with collectivity; titanium dioxide has high luminous reflectance and has dust-proof self-cleaning capability so as to guarantee good diffuse reflection effect. In conclusion, the nanometer diffuse reflection coating is made of high-reflective materials and has the characteristics of high temperature resistance, ageing resistance, dust-proof self-cleaning property and the like.

The invention provides a Milnacipran composition transferred through noses and brains, which contains a Milnacipran original drug or a pharmaceutically acceptable salt thereof and pharmaceutically necessary auxiliary materials. The composition transferred through the noses and the brains can target to a brain tissue, quickly take effect, reduce adverse reaction of the whole body, and is convenient to use.

The invention relates to an oral fast-dissolving film of a xanthophylls-loaded albumin nanoparticle and a preparation method thereof. The preparation method comprises the following steps: preparing the xanthophylls-loaded albumin nanoparticle from xanthophyll by using an anti-solvent precipitation method and then preparing the oral fast-dissolving film of the xanthophylls-loaded albumin nanoparticle by using a solvent casting method. The film prepared in the invention has an intact surface, no bubble, a uniform color and consistent thickness; drug distribution is uniform; and compared with a xanthophyll bulk drug and an oral fast-dissolving film prepared from the xanthophyll bulk drug, the oral fast-dissolving film prepared in the invention is substantially increased in in-vitro release and in-vivo absorption speeds and degrees and obviously improved in bioavailability.

The invention discloses a chemotherapy-phototherapy synergetic anti-tumor microsphere. The microsphere achieves the synergetic anti-tumor effect that 1 plus 1 is greater than 2 simultaneously throughthe combined action of chemotherapy, photodynamic therapy and photothermal therapy, and solves the problem of great toxic and side effects of traditional chemotherapeutic drugs. The invention furtherdiscloses a preparation method and application of the anti-tumor microsphere. The preparation method disclosed by the invention is green and simple, used auxiliary materials and medicines are components which are approved by China and can be used as medicines, introduction of unnecessary components is avoided, and the microsphere has higher safety and compliance.

The invention discloses fruit, vegetable and cyclodextrin supermolecule micro-powder, a method for preparing the same and application of the fruit, vegetable and cyclodextrin supermolecule micro-powder.The fruit, vegetable and cyclodextrin supermolecule micro-powder is mainly made of cyclodextrin, fruits and vegetables.Compared with the prior art, the fruit, vegetable and cyclodextrin supermolecule micro-powder, the method and the application have the advantages that technical difficult problems in the aspect of micronizing fruits and vegetables can be solved by the aid of the simple technological method, the original contents of components of the fresh fruits and the fresh vegetables can be kept to the greatest extent, degradation of macromolecules can be promoted, the contents of water-soluble small-molecular components can be increased, and products have high nutritional available value; the dispersibility and the solubility of the fruits and the vegetables can be improved, nutrition absorption and utilization can be enhanced, and the fruit, vegetable and cyclodextrin supermolecule micro-powder has excellent taste and is low in dose and high in compliance; optional chemical reagents or solvents are omitted in preparation procedures, and accordingly the fruit, vegetable and cyclodextrin supermolecule micro-powder is high in safety; the products are good in flowability, follow-up preparation processing can be facilitated, and the fruit, vegetable and cyclodextrin supermolecule micro-powder is excellent in performance and has fine and uniform particle sizes; the powdery products and preparations are good in stability, long in shelf life and easy to carry, store and transport; the technical method is simple and is free of emission or pollution, and accordingly the fruit, vegetable and the cyclodextrin supermolecule micro-powder, the method and the application conform to the 'efficient, high-quality and environment-friendly' development direction of the food processing industry.