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Pidotimod-containing pharmaceutical composition and preparation method thereof

A technology of pidotimod and its composition, which is applied in the field of pharmaceutical composition containing pidotimod and its preparation, and can solve problems such as discomfort of patients and inaccurate dose control

Inactive Publication Date: 2009-12-30
STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the immunostimulant pidotimod has been widely used clinically. Clinicians can use appropriate antibacterial drugs and pidotimod combined therapy according to the strains of the patient’s infection. bring a lot of discomfort to patients

Method used

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  • Pidotimod-containing pharmaceutical composition and preparation method thereof
  • Pidotimod-containing pharmaceutical composition and preparation method thereof
  • Pidotimod-containing pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Pidotimod and Cloxacillin Tablets

[0011] prescription:

[0012]

[0013] Preparation:

[0014] Pass pidotimod and microcrystalline cellulose through an 80-mesh sieve, mix well, and set aside; take another appropriate amount of 50% ethanol solution, add cloxacillin to dissolve, use this solution as an adhesive to make a soft material, and use a 24-mesh sieve Granulate, dry at 50°C, sieve through a 20-mesh sieve, add micropowder silica gel and CMS-Na, mix well, and press a suitable die to form a tablet.

[0015] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

[0016] Care should be taken to avoid light during the above operations.

Embodiment 2

[0017] Embodiment 2: pidotimod and roxithromycin capsules

[0018] prescription:

[0019]

[0020] Preparation:

[0021] Pass pidotimod through an 80-mesh sieve, mix it with starch evenly, and set aside; take another appropriate amount of 50% ethanol solution, add roxithromycin to dissolve it, use this solution as an adhesive to make a soft material, and make it through a 24-mesh sieve Granules, dried at 50°C, sieved with 20 meshes, added magnesium stearate, mixed evenly, packaged separately, and obtained.

[0022] The used capsule shell can be a common capsule or an enteric-coated capsule.

[0023] The above steps should be strictly protected from light.

Embodiment 3

[0024] Embodiment 3: pidotimod and cefaclor soft capsules

[0025] prescription:

[0026]

[0027] Preparation:

[0028] Dissolve cefaclor and pidotimod in PEG 400, add propylene glycol, stir well, adjust the weight of the contents, and press.

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PUM

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Abstract

The invention provides a pidotimod-containing pharmaceutical composition and a preparation method thereof. The pidotimod-containing pharmaceutical composition consists of pidotimod and any antibacterial medicament. The antibacterial medicament may be any of beta-lactams (including as penicillins, cephems and unclassical beta-lactams), aminoglycosides, polymyxins, macrolides, lincomycins, norvancomycins, tetracyclines, chloromycetins, artificial antibacterial medicaments (including sulfonamides, quinolones and furofurans), cholesterols and antiviral medicaments. The unit dosage of the pidotimod is 0.1 to 2 grams, preferably 0.4 to 0.8 gram. The dosage of the antibacterial medicament is determined according to the dosage range of the antibacterial medicament. The composition of the pidotimod and the antibacterial medicament can exogenously and directly kill pathogenic bacteria through the antibacterial medicament and mobilize endogenous anti-infection immunity through an immunomodulator to improve anti-inflection effect, and has excellent synergy.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing pidotimod and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Pidotimod is an immune enhancer, which can promote both non-specific immune response and specific immune response. Pidotimod can promote the phagocytic activity of macrophages and neutrophils, improve their chemotaxis; activate natural killer cells; promote the proliferation of lymphocytes caused by mitogens, and reduce the helper T cells ( Ratio of CD4+) to suppressor T cells (CD8+) returns to normal; promotes cellular immune response by stimulating interleukin-2 and gamma-interferon. Animal experiments and clinical experiments have shown that although pidotimod has no direct antibacterial and antiviral activity; it can play a significant role in the treatment of bacteria (pneumococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus, etc.) Efficacy of fungal and vi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61K45/06A61K31/43A61P31/04
Inventor 任洪发王晓明孙宇
Owner STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
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